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Full-Text Articles in Sheep and Goat Science
Poor Maternal Nutrition During Gestation Alters Placental Igf-I, Igf-Ii, And Igfbp-3 Mrna Expression In Sheep, Caitlyn Splaine
Poor Maternal Nutrition During Gestation Alters Placental Igf-I, Igf-Ii, And Igfbp-3 Mrna Expression In Sheep, Caitlyn Splaine
Honors Scholar Theses
Insulin-like growth factors (IGF) modulate placental and fetal growth and development through nutrient sensing and endocrine signaling. We hypothesized that poor maternal nutrition during gestation would alter IGF-I, IGF binding protein (IGFBP)-2, and IGFBP-3 mRNA expression in the ovine placenta, but would not affect IGF-II mRNA expression. Pregnant ewes (n=57) were individually fed: 60% (restricted fed; RES), 100% (control fed; CON), or 140% (over fed; OVER) of National Research Council requirements for TDN starting at day 30±0.2 of gestation. Ewes were euthanized and cotyledon and caruncle samples were collected at days 45, 90, and 135 of gestation. Relative mRNA expression …