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Toxic Responses Of The Fish Nervous System, Steven P. Bradbury, Richard W. Carlson, Tala R. Henry, Stephanie Padilla, John Cowden

Steven P. Bradbury

Few of the approximately 70,000 chemicals on the Toxic Substances Control Act inventory or the 1000 to 1600 new chemicals introduced each year in the United States have been tested for neurotoxicity to support risk assessments (NRC, 1992), even though it is estimated that 5 to 10% of them are likely to be neurotoxic. Neurotoxicity has been defined as adverse effects of physical, biological, or chemical agents on the structure or function of the nervous system in developing or adult organisms (Philbert et al., 2000). From a human health risk assessment perspective, the potential for neurotoxic effects associated with synthetic …