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2018

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Full-Text Articles in Life Sciences

Undergraduate Bulletin, 2019-2020, Minnesota State University Moorhead Dec 2018

Undergraduate Bulletin, 2019-2020, Minnesota State University Moorhead

Undergraduate Bulletins (Catalogs)

No abstract provided.


Table Of Contents Dec 2018

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.


An Acoustic Monitoring Method For Assessing River Dolphin Presence And Changes In The Context Of Anthropogenic Development, Charles A. Muirhead Dec 2018

An Acoustic Monitoring Method For Assessing River Dolphin Presence And Changes In The Context Of Anthropogenic Development, Charles A. Muirhead

Graduate Masters Theses

Populations of river dolphins throughout Asia are in decline as a direct result of intensified anthropogenic activity along river systems. Water development projects, land use change, contamination, and intensified fishing practices are known factors contributing to the probable extinction of the Yangtze river dolphin (Lipotes vexillifer) and declining populations of the South Asian river dolphin (Platanista gangetica spp.), Irrawady dolphin (Orcaella brevirostris), and finless porpoise (Neophocaena a. asiaeorientalis). Although not yet as extensive, river system development in South America is following a similar path as that of Asia, with impacts on dolphin species likely to follow. Currently, the Amazon river ...


Methods To Improve The Remediation Of Polycyclic Aromatic Hydrocarbons (Pahs) In Aerobic And Anaerobic Environments, Brian Wartell Dec 2018

Methods To Improve The Remediation Of Polycyclic Aromatic Hydrocarbons (Pahs) In Aerobic And Anaerobic Environments, Brian Wartell

Dissertations

Oil spills occur regularly in terrestrial environments and crude oil can contain many compounds that are highly resistant to degradation. Among these compounds are high levels of polycyclic aromatic hydrocarbons (PAHs) which are not only toxic but can also be carcinogenic and/or mutagenic. The first chapter of this dissertation includes an extensive review chapter on the variables affecting the anaerobic degradation of hydrocarbons, with a particular focus on PAHs. Electron acceptors, electron donors, temperature, salinity, pH all play key roles in determining the possibility effective of effective degradation occurring. Thus, by addressing solutions, such as biostimulation, improving environmental variables ...


Application Of Graphical Models In Protein-Protein Interactions And Dynamics, Amir Vajdi Hoojghan Dec 2018

Application Of Graphical Models In Protein-Protein Interactions And Dynamics, Amir Vajdi Hoojghan

Graduate Doctoral Dissertations

Every organism contains a few hundred to thousands of proteins. A protein is made of a sequence of molecular building blocks named amino acids. Amino acids will be referred to as residues. Every protein performs one or more functions in the cell. In order for a protein to do its job, it requires to bind properly to other partner proteins. Many genetic diseases such as cancer are caused by mutations (changes) of specific residues which cause disturbances in the functions of those proteins.

The problem of prediction of protein binding site is a crucial topic in computational biology. A protein ...


Polya Db3: A Database Cataloging Polyadenation Sites(Pas) Across Different Species And Their Conservation, Ram Mohan Nambiar Dec 2018

Polya Db3: A Database Cataloging Polyadenation Sites(Pas) Across Different Species And Their Conservation, Ram Mohan Nambiar

Theses

Polyadenation is an important process occurring in the messenger RNA that involves cleavage of 3 end nascent mRNAs and addition of poly(A) tails. For this thesis,I present PolyA DB3 ,a database cataloging cleavage and polyadenylation sites (PASs) in several genomes specifically for human,mouse,rat and chicken. This database is based on deep sequencing data. PASs are mapped by the 3’ region extraction and deep sequencing (3’READS) method, ensuring unequivocal PAS identification. Large volume of data based on diverse biological samples is used to increase PAS coverage and provide PAS usage information. Strand-specific RNA-seq data were used ...


Characterization Of A Protozoan Phosducin-Like Protein-3 (Phlp-3) Reveals Conserved Redox Activity, Rachel L. Kooistra, Robin David, Ana C. Ruiz, Sean W. Powers, Kyle J. Haselton, Kaitlyn Kiernan, Andrew M. Blagborough, Ken W. Olsen, Catherine Putonti, Stefan M. Kanzok Dec 2018

Characterization Of A Protozoan Phosducin-Like Protein-3 (Phlp-3) Reveals Conserved Redox Activity, Rachel L. Kooistra, Robin David, Ana C. Ruiz, Sean W. Powers, Kyle J. Haselton, Kaitlyn Kiernan, Andrew M. Blagborough, Ken W. Olsen, Catherine Putonti, Stefan M. Kanzok

Chemistry: Faculty Publications and Other Works

We recently identified three novel thioredoxin-like genes in the genome of the protozoan parasite Plasmodium that belong to the Phosducin-like family of proteins (PhLP). PhLPs are small cytosolic proteins hypothesized to function in G-protein signaling and protein folding. Although PhLPs are highly conserved in eukaryotes from yeast to mammals, only a few representatives have been experimentally characterized to date. In addition, while PhLPs contain a thioredoxin domain, they lack a CXXC motif, a strong indicator for redox activity, and it is unclear whether members of the PhLP family are enzymatically active. Here, we describe PbPhLP-3 as the first phosducin-like protein ...


Post-Wildfire Recovery Of An Upland Oak-Pine Forest On The Cumberland Plateau, Kentucky, Usa, Devin E. Black, Zachary W. Poynter, Claudia A. Cotton, Suraj Upadhaya, David D. Taylor, Wendy Leuenberger, Beth A. Blankenship, Mary A. Arthur Dec 2018

Post-Wildfire Recovery Of An Upland Oak-Pine Forest On The Cumberland Plateau, Kentucky, Usa, Devin E. Black, Zachary W. Poynter, Claudia A. Cotton, Suraj Upadhaya, David D. Taylor, Wendy Leuenberger, Beth A. Blankenship, Mary A. Arthur

Forestry and Natural Resources Faculty Publications

Background: Many forests within the southern Appalachian region, USA, have experienced decades of fire exclusion, contributing to regeneration challenges for species such as oaks (Quercus spp. L.) and pines (Pinus spp. L.), and threatening the maintenance of oak-dominated forests in the future. While the use of prescribed fire as a forest management tool is increasing within this region, there remains a lack of information on the potential role of wildfire. A wildfire within the Daniel Boone National Forest, Kentucky, USA, provided an opportunity to investigate how wildfire affected forest vegetation response.

Results: We examined the effects of fire severity, quantified ...


The International Conference On Intelligent Biology And Medicine (Icibm) 2018: Bioinformatics Towards Translational Applications, Xiaoming Liu, Lei Xie, Zhijin Wu, Kai Wang, Zhongming Zhao, Jianhuan Ruan, Degui Zhi Dec 2018

The International Conference On Intelligent Biology And Medicine (Icibm) 2018: Bioinformatics Towards Translational Applications, Xiaoming Liu, Lei Xie, Zhijin Wu, Kai Wang, Zhongming Zhao, Jianhuan Ruan, Degui Zhi

Publications and Research

The 2018 International Conference on Intelligent Biology and Medicine (ICIBM 2018) was held on June 10–12, 2018, in Los Angeles, California, USA. The conference consisted of a total of eleven scientific sessions, four tutorials, one poster session, four keynote talks and four eminent scholar talks, which covered a wild range of aspects of bioinformatics, medical informatics, systems biology and intelligent computing. Here, we summarize nine research articles selected for publishing in BMC Bioinformatics.


Discerning Novel Splice Junctions Derived From Rna-Seq Alignment: A Deep Learning Approach, Yi Zhang, Xinan Liu, James N. Macleod, Jinze Liu Dec 2018

Discerning Novel Splice Junctions Derived From Rna-Seq Alignment: A Deep Learning Approach, Yi Zhang, Xinan Liu, James N. Macleod, Jinze Liu

Computer Science Faculty Publications

Background: Exon splicing is a regulated cellular process in the transcription of protein-coding genes. Technological advancements and cost reductions in RNA sequencing have made quantitative and qualitative assessments of the transcriptome both possible and widely available. RNA-seq provides unprecedented resolution to identify gene structures and resolve the diversity of splicing variants. However, currently available ab initio aligners are vulnerable to spurious alignments due to random sequence matches and sample-reference genome discordance. As a consequence, a significant set of false positive exon junction predictions would be introduced, which will further confuse downstream analyses of splice variant discovery and abundance estimation.

Results ...


Effects Of Increasing Temperature And Acidification On The Growth And Competitive Success Of Alexandrium Catenella From The Gulf Of Maine, Drajad Seto Dec 2018

Effects Of Increasing Temperature And Acidification On The Growth And Competitive Success Of Alexandrium Catenella From The Gulf Of Maine, Drajad Seto

Electronic Theses and Dissertations

The increases in ocean temperature and pCO2 due to climate change are projected to affect the growth and future prevalence of Harmful Algal Blooms (HABs) in nearshore waters, but systematic studies on the effects these climate drivers have on harmful algal species are lacking. In particular, little is known about how future climate scenarios will affect the growth of the toxic dinoflagellate Alexandrium catenella, which produces the toxins responsible for paralytic shellfish poisoning (PSP) that threaten the health and economy of coastal communities in the Gulf of Maine. I examined growth responses of A. catenella and two other naturally co-occurring ...


Physicochemical Organic Matter Stabilization Across A Restored Grassland Chronosequence, Shane M. Bugeja, Michael J. Castellano Dec 2018

Physicochemical Organic Matter Stabilization Across A Restored Grassland Chronosequence, Shane M. Bugeja, Michael J. Castellano

Agronomy Publications

In reconstructed grasslands, soil organic matter (SOM) is the largest CO2 and reactive N sink but SOM gains after reconstruction rarely achieve precultivation levels. Through a chronosequence of reconstructed grasslands 1 to 21 yr after establishment, we explored which physicochemical mechanisms protect accumulated soil organic C (SOC) and N from mineralization. After 21 yr, total SOC and soil N concentrations increased by 32 and 23%. The SOC concentration was within 5% of a new equilibrium but was 64% of a never‐cultivated remnant. Chemically stabilized C and N pools on free silt and clay surfaces increased with time. Coarse particulate ...


Quantifying Bee Assemblages And Attractiveness Of Flowering Woody Landscape Plants For Urban Pollinator Conservation, Bernadette M. Mach, Daniel A. Potter Dec 2018

Quantifying Bee Assemblages And Attractiveness Of Flowering Woody Landscape Plants For Urban Pollinator Conservation, Bernadette M. Mach, Daniel A. Potter

Entomology Faculty Publications

Urban and suburban landscapes can be refuges for biodiversity of bees and other pollinators. Public awareness of declining pollinator populations has increased interest in growing plants that provide floral resources for bees. Various publications and websites list “bee-friendly” plants, but such lists are rarely based on empirical data, nor do they emphasize flowering trees and shrubs, which are a major component of urban landscapes. We quantified bee visitation to 72 species of flowering woody landscape plants across 373 urban and suburban sites in Kentucky and southern Ohio, USA, sampling and identifying the bee assemblages associated with 45 of the most ...


Simulating Detection-Censored Movement Records For Home Range Analysis Planning, Lyndsie S. Wszola, Victoria L. Simonsen, Lucía Corral, Christopher J. Chizinski, Joseph J. Fontaine Dec 2018

Simulating Detection-Censored Movement Records For Home Range Analysis Planning, Lyndsie S. Wszola, Victoria L. Simonsen, Lucía Corral, Christopher J. Chizinski, Joseph J. Fontaine

Nebraska Cooperative Fish & Wildlife Research Unit -- Staff Publications

Home range estimation is an important analytical method in applied spatial ecology, yet best practices for addressing the effects of spatial variation in detection probability on home range estimates remain elusive. We introduce the R package “DiagnoseHR,” simulation tools for assessing how variation in detection probability arising from landscape, animal behavior, and methodological processes affects home range inference. We demonstrate the utility of simulation methods for home range analysis planning by comparing bias arising from three home range estimation methods under multiple detection scenarios. We simulated correlated random walks in three landscapes that varied in detection probability and constructed home ...


1998 - 2030 Land Use And Water Needs Conditions Dec 2018

1998 - 2030 Land Use And Water Needs Conditions

Miscellaneous Monterey and San Luis Obispo County Documents and Reports

Documentation of the methodology and data used to estimate the land use, M&I water needs, and pumped agricultural water under the 2030 conditions. One of the primary goals of the Salinas River Basin Management Plan (BMP) is to meet the agricultural, and municipal and industrial water needs of the Valley under the existing conditions (1995 level of development) as well as, under the future conditions (2030 level of development), while stopping the seawater intrusion and balancing the hydrologic conditions in the basin. In order to meet the 2030 water needs, a reasonable estimate of land use and water use conditions is required.

The major sources used to develop the future land use and water use estimates are as follows: MCWRA Ground Water Extraction Management System; MCWRA GIS Land Use Coverage; Association of Monterey Bay Area Governments and Salinas Valley Integrated Ground and Surface Water Model


1998 - Salinas Valley Water (Preliminary Analysis Of) The Cause And Cost Of Seawater Intrusion Dec 2018

1998 - Salinas Valley Water (Preliminary Analysis Of) The Cause And Cost Of Seawater Intrusion

Miscellaneous Monterey and San Luis Obispo County Documents and Reports

An analysis of the historical cause of seawater intrusion in the Pressure Area of Monterey County. An annual overdraft of groundwater resources near the coast coupled with a seasonal cycle of over pumping created a reversal in the groundwater gradient and associated cones of depression. "Marine intrusion has occurred in the 180-foot aquifer in recent years as a result of overdrafts." (Bulletin 52, 1946, p.27). The only overdrafts on groundwater in the Salinas Valley were in the East Side and Pressure Areas. "There was no shortage of groundwater in the remainder of the basin and no threat of deficiency ...


1995 - North Monterey County Hydrogeologic Study Volume I, Water Resource Dec 2018

1995 - North Monterey County Hydrogeologic Study Volume I, Water Resource

Monterey County Water Resources Agency Engineering Reports

The purpose of the investigation was to develop a better understanding of the hydrogeologic setting in the North Monterey County (North County) area and to quantify the various components of water supply and demand. The investigation also focused on the institutional and planning issues associated with the resource limitations and suggests possible responses to these limitations. The investigation was intended to provide the Monterey County Water Resources Agency (MCWRA), as well as the Monterey County Departments of Planning, Building & Inspection and Division of Environmental Health, with data essential to developing a ground water management plan and to support modifications to ...


1996 - Monterey County Hydrogeologic Study, Volume Ii -- Critical Issues Report And Interim Management Plan, Final Report Dec 2018

1996 - Monterey County Hydrogeologic Study, Volume Ii -- Critical Issues Report And Interim Management Plan, Final Report

Monterey County Water Resources Agency Engineering Reports

This document was a companion report to the North Monterey County Hydrogeologic Study, Volume I, dated October 1995. The document built from the technical understanding and problem identification developed in Volume I and focuses on key issues relative to developing a management plan for the water resources of the area. These included the interrelated policy, legal and financial issues that complicate the management of the resource. The purpose of the report was to provide an analysis of these issues towards the development of long-range management objectives.


2018 - Groundwater Management In California, Michael Hanemann Dec 2018

2018 - Groundwater Management In California, Michael Hanemann

Related Research and Documents

In 2014, the California legislature for the first time took some steps to create a framework for regulating groundwater pumping in over-drafted basins by adopting the Sustainable Groundwater Management Act (SGMA), representing California's first statewide groundwater management planning program. SGMA called for local agencies to develop groundwater sustainability plans within the next five to seven years and then achieve sustainable levels of groundwater extraction by approximately 2040 to 2045. California's prior efforts to regulate groundwater extraction is discussed, as well as groundwater depletion.


2000 - Geology Bibliography Of California, 1854–2000 Dec 2018

2000 - Geology Bibliography Of California, 1854–2000

Miscellaneous Monterey and San Luis Obispo County Documents and Reports

The scope of this database is much broader in scope than the original list of consultant reports submitted to Monterey County governmental agencies and includes extensive references on regional geologic mapping, hydrogeology, economic geology, and research done in connection with the Parkfield Earthquake Prediction Experiment.

Major sources of information include:

• Monterey County Planning Department: a database of approximately 2,000 references within the

categories of geology, soil, water resources, and water quality.

• Monterey County Water Resources Agency.

• Monterey Peninsula Water Management District.

• The American Geological Institute’s GeoRef database.

• The U.S. Geological Survey’s National Geologic Map Database.

• An ...


Facilitating Pre-Service Teachers To Engage Emergent Bilinguals In Productive Struggle, Benjamin T. Dickey, Jim Ewing, Melissa Caruso, Emily D. Fulmer Dec 2018

Facilitating Pre-Service Teachers To Engage Emergent Bilinguals In Productive Struggle, Benjamin T. Dickey, Jim Ewing, Melissa Caruso, Emily D. Fulmer

Journal of Multicultural Affairs

This study utilized a multiple case study with qualitative research to examine how Pre-service teachers (PSTs) might engage Emergent Bilinguals (EBs) in productive struggle—grappling to solve problems (Warshauer, 2015). The researchers created a rubric based on Warshauer’s (2015) case study to record the types of questions PSTs asked as they tutored fourth grade EBs. Warshauer (2015) claimed PSTs should allow students more wait time and ask questions. She referred to such questions as affordance and probing guidance, which facilitates productive struggle. In order to discover more about the PSTs’ thinking, the researchers interviewed the PSTs before and after ...


Power In Pairs: Assessing The Statistical Value Of Paired Samples In Tests For Differential Expression, John R. Stevens, Jennifer S. Herrick, Roger K. Wolff, Martha L. Slattery Dec 2018

Power In Pairs: Assessing The Statistical Value Of Paired Samples In Tests For Differential Expression, John R. Stevens, Jennifer S. Herrick, Roger K. Wolff, Martha L. Slattery

Mathematics and Statistics Faculty Publications

Background: When genomics researchers design a high-throughput study to test for differential expression, some biological systems and research questions provide opportunities to use paired samples from subjects, and researchers can plan for a certain proportion of subjects to have paired samples. We consider the effect of this paired samples proportion on the statistical power of the study, using characteristics of both count (RNA-Seq) and continuous (microarray) expression data from a colorectal cancer study.

Results: We demonstrate that a higher proportion of subjects with paired samples yields higher statistical power, for various total numbers of samples, and for various strengths of ...


The Catalytic Mechanism Of Electron-Bifurcating Electron Transfer Flavoproteins (Etfs) Involves An Intermediary Complex With Nad+, Gerrit J. Schut, Nishya Mohamed-Raseek, Monika Tokmina-Lukaszewska, David W. Mulder, Diep M. N. Nguyen, Gina L. Lipscomb, John Patrick Hoben, Angela Patterson, Carolyn E. Lubner, Paul W. King, John W. Peters, Brian Bothner, Anne-Frances Miller, Michael W. W. Adams Dec 2018

The Catalytic Mechanism Of Electron-Bifurcating Electron Transfer Flavoproteins (Etfs) Involves An Intermediary Complex With Nad+, Gerrit J. Schut, Nishya Mohamed-Raseek, Monika Tokmina-Lukaszewska, David W. Mulder, Diep M. N. Nguyen, Gina L. Lipscomb, John Patrick Hoben, Angela Patterson, Carolyn E. Lubner, Paul W. King, John W. Peters, Brian Bothner, Anne-Frances Miller, Michael W. W. Adams

Chemistry Faculty Publications

Electron bifurcation plays a key role in anaerobic energy metabolism, but it is a relatively new discovery, and only limited mechanistic information is available on the diverse enzymes that employ it. Herein, we focused on the bifurcating electron transfer flavoprotein (ETF) from the hyperthermophilic archaeon Pyrobaculum aerophilum. The EtfABCX enzyme complex couples NADH oxidation to the endergonic reduction of ferredoxin and exergonic reduction of menaquinone. We developed a model for the enzyme structure by using nondenaturing MS, cross-linking, and homology modeling in which EtfA, -B, and -C each contained FAD, whereas EtfX contained two [4Fe-4S] clusters. On the basis of ...


2010 - Excerpt From Master Response 4 - Water Supply Re Salinas Valley Water Supply (10-28-10) Dec 2018

2010 - Excerpt From Master Response 4 - Water Supply Re Salinas Valley Water Supply (10-28-10)

Miscellaneous Monterey and San Luis Obispo County Documents and Reports

In addition to the Master Response to the Monterey County General Plan pertaining to the analysis of the Salinas Valley water supply, tables and figures referenced in the response are included at the end of the response. This document is for informational purposes only to provide a summary of information relative to the Salinas Valley water supply analysis contained in the Final EIR.


2008 - San Antonio And Nacimiento Rivers Watershed Management Plan Dec 2018

2008 - San Antonio And Nacimiento Rivers Watershed Management Plan

Miscellaneous Monterey and San Luis Obispo County Documents and Reports

The purpose of the San Antonio and Nacimiento Rivers Watersheds Management Plan is to identify the existing conditions of and stresses in these watersheds as they relate to water quality, and recommend methods for reducing or eliminating those stressors such as alternative land use practices. The plan was created to:

􀂃 The reservoirs and their respective watersheds are the source for water recharging the Salinas Valley groundwater basin.

􀂃 There is a direct correlation between the health of these watersheds and the supply and quality of water for the Salinas Valley.

􀂃 The Salinas Valley’s population and economy are dependent on a ...


2012 - Historic American Landscapes Survey - Mission San Antonio De Padua Dec 2018

2012 - Historic American Landscapes Survey - Mission San Antonio De Padua

Miscellaneous Monterey and San Luis Obispo County Documents and Reports

The intent of this report was to summarize existing written histories of the site and to document the existing conditions of the physical and cultural landscape at the Mission, This report focused on the viewshed and overall physical and cultural landscape of Mission San Antonio de Padua and its surroundings. There are no drawings of the site included in this documentation nor was the precise location and species of each plant type within the study area have not been documented or recorded. The study area encompasses approximately 650 acres.


2006 - Salinas Valley Integrated Regional Water Management Functionally Equivalent Plan Summary Document Update Dec 2018

2006 - Salinas Valley Integrated Regional Water Management Functionally Equivalent Plan Summary Document Update

Miscellaneous Monterey and San Luis Obispo County Documents and Reports

The California Department of Water Resources (DWR) and the State Water Resources Control Board (SWRCB) are encouraging local and regional water management planners to establish integrated regional water management plans through the collaboration of planning efforts and project coordination. The intent is to encourage planners to implement projects focused on meeting multiple water resources needs on a regional basis. Jointly, both agencies are soliciting grant applications for Proposition 50 Chapter 8 grant funding, which was established to provide a fiscal tool to support integrated regional water management. In order to take advantage of this funding opportunity, Monterey County Water Resources ...


2008 - Managing An Uncertain Future - Climate Change Adaptation Strategies For California's Water Dec 2018

2008 - Managing An Uncertain Future - Climate Change Adaptation Strategies For California's Water

Miscellaneous Documents and Reports

This report recommends a number of adaptation strategies for California and local water managers to improve their capacity to handle change. Many of the strategies will also help adapt California's water resources to accommodate non-climate demands including a growing population, ecosystem restoration and greater flood protection. Several of the recommendations in this report are ready for immediate adoption, while others need additional public deliberation and development. Some can be implemented using existing resources and authority, while the majority will require new resources, sustained financial investment and significant collaborative effort.


Dichotomous Scoring Of Tdp-43 Proteinopathy From Specific Brain Regions In 27 Academic Research Centers: Associations With Alzheimer's Disease And Cerebrovascular Disease Pathologies, Yuriko Katsumata, David W. Fardo, Walter A. Kukull, Peter T. Nelson Dec 2018

Dichotomous Scoring Of Tdp-43 Proteinopathy From Specific Brain Regions In 27 Academic Research Centers: Associations With Alzheimer's Disease And Cerebrovascular Disease Pathologies, Yuriko Katsumata, David W. Fardo, Walter A. Kukull, Peter T. Nelson

Biostatistics Faculty Publications

TAR-DNA binding protein 43 (TDP-43) proteinopathy is a common brain pathology in elderly persons, but much remains to be learned about this high-morbidity condition. Published stage-based systems for operationalizing disease severity rely on the involvement (presence/absence) of pathology in specific anatomic regions. To examine the comorbidities associated with TDP-43 pathology in aged individuals, we studied data from the National Alzheimer’s Coordinating Center (NACC) Neuropathology Data Set. Data were analyzed from 929 included subjects with available TDP-43 pathology information, sourced from 27 different American Alzheimer’s Disease Centers (ADCs). Cases with relatively unusual diseases including autopsy-proven frontotemporal lobar degeneration ...


Large-Scale Genome-Wide Meta-Analysis Of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture For Different Diagnosis Criteria, Felix Day, Tugce Karaderi, Michelle R. Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Magi, Richa Saxena, Triin Laisk, Margrit Urbanek, M. Geoffrey Hayes, Gudmar Thorleifsson, Juan Fernandez-Tajes, Anubha Mahajan, Benjamin H. Mullin, Bronwyn G. A. Stuckey, Timothy D. Spector, Scott G. Wilson, Mark O. Goodarzi, Lea Davis, Barbara Obermayer-Pietsch, André G. Uitterlinden, Verneri Anttila, Benjamin M. Neale, Marjo-Riitta Jarvelin, Bart Fauser Dec 2018

Large-Scale Genome-Wide Meta-Analysis Of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture For Different Diagnosis Criteria, Felix Day, Tugce Karaderi, Michelle R. Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Magi, Richa Saxena, Triin Laisk, Margrit Urbanek, M. Geoffrey Hayes, Gudmar Thorleifsson, Juan Fernandez-Tajes, Anubha Mahajan, Benjamin H. Mullin, Bronwyn G. A. Stuckey, Timothy D. Spector, Scott G. Wilson, Mark O. Goodarzi, Lea Davis, Barbara Obermayer-Pietsch, André G. Uitterlinden, Verneri Anttila, Benjamin M. Neale, Marjo-Riitta Jarvelin, Bart Fauser

Internal Medicine Faculty Publications

Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have metabolic disturbances including insulin resistance and dysregulation of glucose homeostasis. PCOS is diagnosed with two different sets of diagnostic criteria, resulting in a phenotypic spectrum of PCOS cases. The genetic similarities between cases diagnosed based on the two criteria have been largely unknown. Previous studies in Chinese and European subjects have identified 16 loci associated with risk of PCOS. We report a fixed-effect, inverse-weighted-variance meta-analysis from 10,074 PCOS cases and 103,164 controls of European ancestry and characterisation of ...