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Full-Text Articles in Life Sciences
Improving Codon Evolution Models Using Complex Mutation Models, Preston Hewgley
Improving Codon Evolution Models Using Complex Mutation Models, Preston Hewgley
Pursuit - The Journal of Undergraduate Research at The University of Tennessee
This paper discusses an improvement in a Stochastic Evolutionary Model of Protein Production Rate (SEMPPR) by revising the method by which it models mutation. SEMPPR previously assumed unbiased mutation, an assumption whose inaccuracy is made clear by observed codon counts of low-expression genes, where mutation determines equilibrium state. This paper presents a new, more complex model generalized on a per-codon basis and calculated from observed codon frequencies using a maximum likelihood framework. Results obtained from SEMPPR using the codon specific mutation model proved more accurate in predicting a protein’s production rate, reaffirming that complex mechanisms govern codon mutation rates.
Metabolic Rescue Of “Glucose Addicted” Cancer Cells In Vitro, Paolo Vignali
Metabolic Rescue Of “Glucose Addicted” Cancer Cells In Vitro, Paolo Vignali
Pursuit - The Journal of Undergraduate Research at The University of Tennessee
Transformations in the glycolytic metabolism of neoplasms modulate their robust cellular division. This characteristic leads to an “addiction” to glucose for continued proliferation and viability. This study investigated whether glucose metabolites could rescue cellular viability in glucose-starvation conditions, a model of the inter-tumoral nutrient-deficient environment. Findings illustrated potential cellular viability rescue with pyruvate addition in glucose-deprived conditions, yet the same potential was not observed with lactic acid, a metabolite that exists at characteristically high concentrations within the intertumoral microenvironment. These results could implicate a predominance of certain metabolic pathways in nutrient-starved cells. Molecular transport capacities across plasma membranes are tied …
Front Matter, Southeastern Fishes Council
Front Matter, Southeastern Fishes Council
Southeastern Fishes Council Proceedings
No abstract provided.
Post-Hurricane Katrina Survey For The Blackmouth Shiner (Notropis Melanostomus) At Historical Localities In Mississippi, Martin T. O'Connell, Anne M. Usee O'Connell
Post-Hurricane Katrina Survey For The Blackmouth Shiner (Notropis Melanostomus) At Historical Localities In Mississippi, Martin T. O'Connell, Anne M. Usee O'Connell
Southeastern Fishes Council Proceedings
No abstract provided.
Reproductive Biology Of The Frecklebelly Darter, Percina Stictogaster (Teleostei: Percidae), David J. Eisenhour, Audrey M. Richter, Lynn V. Eisenhour, Carol-Rose Gingras
Reproductive Biology Of The Frecklebelly Darter, Percina Stictogaster (Teleostei: Percidae), David J. Eisenhour, Audrey M. Richter, Lynn V. Eisenhour, Carol-Rose Gingras
Southeastern Fishes Council Proceedings
No abstract provided.
Minutes, Business Meeting, 37th Annual Meeting, Southeastern Fishes Council, Southeastern Fishes Council
Minutes, Business Meeting, 37th Annual Meeting, Southeastern Fishes Council, Southeastern Fishes Council
Southeastern Fishes Council Proceedings
No abstract provided.
Rediscovery Of A Lost Paratype Of The Boulder Darter, Etheostoma Wapiti, Michael H. Doosey
Rediscovery Of A Lost Paratype Of The Boulder Darter, Etheostoma Wapiti, Michael H. Doosey
Southeastern Fishes Council Proceedings
No abstract provided.
2011 Treasurer's Report For The Southeastern Fishes Council, Southeastern Fishes Council
2011 Treasurer's Report For The Southeastern Fishes Council, Southeastern Fishes Council
Southeastern Fishes Council Proceedings
No abstract provided.