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Full-Text Articles in Life Sciences

An Annotated Atlas Of The Freshwater Fishes Of North Carolina, Bryn H. Tracy, Fred C. Rohde, Gabriela M. Hogue Oct 2020

An Annotated Atlas Of The Freshwater Fishes Of North Carolina, Bryn H. Tracy, Fred C. Rohde, Gabriela M. Hogue

Southeastern Fishes Council Proceedings

North Carolina’s first state-specific checklist of freshwater fish species was published in 1709 by John Lawson. Subsequent species lists with descriptions included: Brickell (1737), Cope (1870a), Jordan (1889a), Jordan and Evermann (1896-1900), Smith (1907), Jordan et al. (1930), Fowler (1945), Louder (1962), Ratledge et al. (1966), Menhinick et al. (1974). In 1991, Menhinick published “The Freshwater Fishes of North Carolina”, which is still widely in use because a comprehensive update has not been produced since its publication. The increase in the availability of historical records in globally accessible databases and the surge of collections post-1991 made by federal and ...


Size Selective Parasitism Of Rainbow Trout (Oncorhynchus Mykiss) By Chestnut Lampreys (Ichthyomyzon Castaneus) In An Artificial Setting, Jeremiah M. Salinger, Ronald L. Johnson May 2020

Size Selective Parasitism Of Rainbow Trout (Oncorhynchus Mykiss) By Chestnut Lampreys (Ichthyomyzon Castaneus) In An Artificial Setting, Jeremiah M. Salinger, Ronald L. Johnson

Southeastern Fishes Council Proceedings

Paradigms of optimal resource utilization by animals, both classical and more recent, were not originally developed in the context of parasitism. Though this oversight has slowly been reversed, little attention has been paid to optimal resource utilization by parasitic fishes, such as lampreys. Multiple explanations for host size selection by parasitic lampreys may be plausible, but results from previous studies have been inconsistent. We studied host size selection by Chestnut Lampreys (Ichthyomyzon castaneus) parasitizing Rainbow Trout (Oncorhynchus mykiss) in fish hatchery raceways in north central Arkansas during the late winter and early spring of 2013. Parasitized Rainbow Trout were significantly ...


Movement Of Translocated Adult Sicklefin Redhorse (Moxostoma Sp.) In The Oconaluftee River, North Carolina: Implications For Species Restoration, Jessica L. Davis, David P. Gillette, C. Reed Rossell Jr., Michael J. Lavoie May 2020

Movement Of Translocated Adult Sicklefin Redhorse (Moxostoma Sp.) In The Oconaluftee River, North Carolina: Implications For Species Restoration, Jessica L. Davis, David P. Gillette, C. Reed Rossell Jr., Michael J. Lavoie

Southeastern Fishes Council Proceedings

The Sicklefin Redhorse is a rare, undescribed species of Moxostoma, endemic to the Hiwassee and Little Tennessee River basins of western North Carolina and northern Georgia, where it has been eliminated from much of its native range. It is listed as endangered in Georgia and threatened in North Carolina. Although it has not been granted federal protected status, this species is the subject of a Candidate Conservation Agreement between federal, state, tribal, and private stakeholders, of which one objective calls for the re-establishment of Sicklefin Redhorse populations throughout its historical range. The objective of our study was to evaluate suitability ...


Status Of The Blackstripe (Fundulus Notatus) And Blackspotted (F. Olivaceus) Topminnows In The Ozark Uplands Of Central Missouri, Nathaniel Steffensmeier, Naznin Sultana Remex, Robert Hrabik, David D. Duvernell May 2020

Status Of The Blackstripe (Fundulus Notatus) And Blackspotted (F. Olivaceus) Topminnows In The Ozark Uplands Of Central Missouri, Nathaniel Steffensmeier, Naznin Sultana Remex, Robert Hrabik, David D. Duvernell

Southeastern Fishes Council Proceedings

The topminnow species Fundulus notatus and F. olivaceus have broadly overlapping geographic distributions that extend throughout much of the central and southern United States. In the northern portion of their respective ranges, in Missouri, the regional distributions of the two species coincide largely with recognized ecoregions. In the unglaciated southern half of Missouri, F. olivaceus is distributed throughout Ozark upland habitats while F. notatus is abundant in marginal large river and prairie habitats along the Ozark borders. An exception to this partitioning is the historical report of abundant F. notatus in the Bourbeuse and upper Meramec River drainages within the ...


Use Of Dead Mussel Shells By Madtom Catfishes In The Green River, Jacob F. Brumley, Philip W. Lienesch May 2020

Use Of Dead Mussel Shells By Madtom Catfishes In The Green River, Jacob F. Brumley, Philip W. Lienesch

Southeastern Fishes Council Proceedings

The Green River in Kentucky has high fish and macroinvertebrate diversity. As both fish and macroinvertebrates have evolved together in this system, relationships have developed between species. One type of relationship that has been observed is between madtom catfishes (Noturus spp.) and mussels in the Green River, where madtoms use dead mussel shells as cover when not actively foraging. In the fall of 2016 and 2017, surveys were conducted to determine if madtom catfishes use dead mussel shells more than rocks of similar size. We predicted that madtoms would select mussel shells as cover more frequently than rocks due to ...


Molecular Characterization Of A Gene Encoding Insulin-Like Peptide 5 (Ilp5) In Drosophila Virilis, Nikolas R. Likourentzos, Jae H. Park May 2020

Molecular Characterization Of A Gene Encoding Insulin-Like Peptide 5 (Ilp5) In Drosophila Virilis, Nikolas R. Likourentzos, Jae H. Park

Pursuit - The Journal of Undergraduate Research at the University of Tennessee

The study of the insulin-like peptides of Drosophila can provide insight of their similarities to mammalian insulin and their potential usage in treating human insulin-related diseases. In this study, we isolated and characterized cDNA encoding insulin-like peptide (ILP) 5 in D. virilis by using RNA purification, reverse transcription, and RACE protocols. Subsequently, various bioinformatic softwares were employed to predict peptide structure. The ILP5 gene (587 base pairs) codes for 121 amino acids that make up prepro-ILP5. After maturation, functional ILP5 is a peptide of two 25 amino acid chains, A- and B-chain, connected by two disulfide bonds. Sequencing genomic DNA ...


The Current Neuroscientific Understanding Of Alzheimer's Disease, Rachel A. Brandes May 2020

The Current Neuroscientific Understanding Of Alzheimer's Disease, Rachel A. Brandes

Pursuit - The Journal of Undergraduate Research at the University of Tennessee

Alzheimer’s disease is a degenerative neurological illness characterized by the deterioration of brain regions implicated in memory and cognitive function. While researchers have yet to find a cure or effective treatment, they have gained a better understanding of its pathology and development. Through years of neuroscience research, scientists have discovered much of what happens in the brain during Alzheimer’s disease onset and how this causes its symptoms; many hypotheses regarding this aspect of the illness involve temporal lobe atrophy, neurofibrillary tangles, and amyloid plaques. Although Alzheimer’s disease affects millions of people every day, it seems that most ...


Outperformed: Exploration And Comparison Of The Tongue-And-Cheek Tragedies Of Women-Animal Relationships In Selected Short Stories By Samanta Schweblin And In Apichatpong Weerasethakul’S Film, Uncle Boonmee Who Can Recall His Past Lives, Sawnie Smith Apr 2020

Outperformed: Exploration And Comparison Of The Tongue-And-Cheek Tragedies Of Women-Animal Relationships In Selected Short Stories By Samanta Schweblin And In Apichatpong Weerasethakul’S Film, Uncle Boonmee Who Can Recall His Past Lives, Sawnie Smith

Vernacular: New Connections in Language, Literature, & Culture

The unsettling short stories that comprise Samanta Schweblin’s 2008 collection Pájaros en la boca are textured and populated by the flesh of not only humans, but also the skins of species that belong to a wider zoological and mythical scope. Those creatures in Schweblin’s literary output who possess scales, feathers, and wings find themselves variously rubbing up against, crushed under, and orally engulfed by human dermis. This essay seeks to explore the charge of gender politics that courses through interactions between human women and (demi-) animals in two short stories from this collection: “El hombre sirena” and “Olingiris ...


Aspects Of The Reproductive Biology And Growth Of The Mississippi Silvery Minnow, Hybognathus Nuchalis (Agassiz, 1855) (Teleostei: Cyprinidae) From The Pearl River, Louisiana., Arely Ramírez-García, Kyle R. Piller Nov 2018

Aspects Of The Reproductive Biology And Growth Of The Mississippi Silvery Minnow, Hybognathus Nuchalis (Agassiz, 1855) (Teleostei: Cyprinidae) From The Pearl River, Louisiana., Arely Ramírez-García, Kyle R. Piller

Southeastern Fishes Council Proceedings

The reproductive biology and growth of the Mississippi Silvery Minnow, Hybognathus nuchalis, is described from multiple sites in the Pearl River, Louisiana. Individuals were collected from August 2011 to August 2012. Ovarian weights, expressed as a percentage of body weights, peaked in December. Size structure ranged from 29.0 to 60.0 mm SL for females and 25.0 to 56.0 mm SL for males. Mature ova were found from November to January. Females reached first maturity (L50) at 37.0 mm SL and L50 for males is at 41.0 mm SL. Sex ratio (females:males) is biased ...


Multi-Metric Conservation Assessment For The Imperiled Clinch Dace, Michael James Moore, Donald J. Orth, Eric M. Hallerman Nov 2018

Multi-Metric Conservation Assessment For The Imperiled Clinch Dace, Michael James Moore, Donald J. Orth, Eric M. Hallerman

Southeastern Fishes Council Proceedings

Planning frameworks allow managers to spatially prioritize actions to promote species conservation. Traditional aquatic conservation planning frameworks are often organized at the ecological community or ecosystem level, which often neglect imperiled taxa occupying species-poor assemblages. In this study, we develop a multi-metric conservation assessment for the 15 geographically distinct candidate conservation areas (CCAs) occupied by the imperiled Clinch Dace (Chrosomus sp. cf. saylori). Clinch Dace habitat is threatened by anthropogenic landscape alterations, especially for coal mining and timber harvest. Our framework used four metrics to assess the conservation value of each subpopulation of Clinch Dace namely: “habitat condition”, “viability”, conservation ...


Reproductive Timing Of The Scarlet Shiner (Lythrurus Fasciolaris) In Northern Alabama, Bruce Stallsmith, Toacca Taylor, Chelsie Smith Sep 2018

Reproductive Timing Of The Scarlet Shiner (Lythrurus Fasciolaris) In Northern Alabama, Bruce Stallsmith, Toacca Taylor, Chelsie Smith

Southeastern Fishes Council Proceedings

The Scarlet Shiner (Lythrurus fasciolaris) is a cyprinid species widely distributed in parts of the Ohio, Cumberland and Tennessee river drainages of the United States. The objective of this study was to determine the Scarlet Shiner’s reproductive schedule. Maturation of ovaries and oocytes was determined through the categorization of developmental stages from early maturing to ripe, along with the calculation of monthly gonadosomatic index (GSI) measurements over two reproductive seasons in 2012 and 2015. In both years reproductive competence began in April. Average monthly GSI for females peaked in May, followed by a slow decline through August. Average clutch ...


Updated Distributional Records Of Selected Kentucky Fishes, David J. Eisenhour, Matthew R. Thomas, J. Jacob Culp, Michael C. Compton, Stephanie L. Brandt, Rodney Pierce Aug 2018

Updated Distributional Records Of Selected Kentucky Fishes, David J. Eisenhour, Matthew R. Thomas, J. Jacob Culp, Michael C. Compton, Stephanie L. Brandt, Rodney Pierce

Southeastern Fishes Council Proceedings

Distribution records for 15 fish species of conservation interest are included for Kentucky. Notropis dorsalis, previously undocumented in Kentucky, is reported for the first time (Mayfield Creek drainage). Also reported are state rediscoveries of three species thought to be extirpated from Kentucky: Ichthyomyzon gagei (Tennessee River drainage), Hemitremia flammea (Lower Cumberland and Green river drainages), and Hybopsis amnis (upper Cumberland River drainage). Unreported drainage records comprise nine species: Ichthyomyzon castaneus (Salt River drainage and Upper Green River drainage); Ichthyomyzon unicuspis (Salt River drainage and upper Big Sandy River drainage); Campostoma pullum (Tennessee River drainage); Umbra limi (Obion Creek drainage); Lepomis ...


Vegetation And Arthropod Responses To Brush Reduction By Grubbing And Stacking, Carter Crouch, J. Alfonso Ortega-Santos, David B. Wester, Fidel Hernández, Leonard A. Brennan, Greta L. Schuster Nov 2017

Vegetation And Arthropod Responses To Brush Reduction By Grubbing And Stacking, Carter Crouch, J. Alfonso Ortega-Santos, David B. Wester, Fidel Hernández, Leonard A. Brennan, Greta L. Schuster

National Quail Symposium Proceedings

Grubbing is a mechanical brush-reduction technique that allows targeting of mesquite (Prosopis glandulosa) and huisache (Vachellia farnesiana) and can be used to open lanes for hunting northern bobwhites (Colinus virginianus). Follow-up treatments of stacking allow the piling up of downed brush. We initiated this study on the Santa Gertrudis Division of the King Ranch, Inc., Texas, to determine effects of grubbing and stacking on vegetation and arthropod communities important to bobwhite. We hypothesized that grubbing and stacking would be able to selectively remove mesquite and huisache while leaving mixed brush species largely intact. We hypothesized that soil disturbance treatments would ...


Physiological Ecology Of Four Endemic Alabama Species And The Exotic Asiatic Weatherfish, Misgurnus Anguillicaudatus (Cantor, 1842), Lindsay M. White, Mark E. Meade, Benjamin A. Staton Sep 2017

Physiological Ecology Of Four Endemic Alabama Species And The Exotic Asiatic Weatherfish, Misgurnus Anguillicaudatus (Cantor, 1842), Lindsay M. White, Mark E. Meade, Benjamin A. Staton

Southeastern Fishes Council Proceedings

The occurrence of Asiatic Weatherfish, Misgurnus anguillicaudatus, in Alabama, a state known for its rich biodiversity, has generated concern among conservation managers. The current study used respirometry techniques to investigate the effects of increasing temperature on four native southeastern fishes (one cyprinid, two percids, and one elassomid) and the non-native M. anguillicaudatus. A minimum of five individuals of each species were used, and three experimental temperatures were chosen to represent spring and summer averages of northeast Alabama streams (15, 20, and 25°C). Overall, mean standard metabolic rates (SMRs) for M. anguillicaudatus were low (97.01, 127.75, and 158 ...


First Report Of A Population Of Western Blacknose Dace (Rhinichthys Obtusus) In The Brushy Creek System Of The Black Warrior River Drainage, Alabama, Eric Bauer, Malorie M. Hayes Sep 2017

First Report Of A Population Of Western Blacknose Dace (Rhinichthys Obtusus) In The Brushy Creek System Of The Black Warrior River Drainage, Alabama, Eric Bauer, Malorie M. Hayes

Southeastern Fishes Council Proceedings

Alabama is home to the southernmost populations of Rhinichthys obtusus, the Western Blacknose Dace. Within Alabama, R. obtusus is found in the Tennessee, Coosa, and Black Warrior River basins, but its presence in the Black Warrior River drainage has been limited. Until now, R. obtusus in the Black Warrior drainage has only been reported as collections of 1 to 4 specimens at a time in the Sipsey Fork drainage. Herein, we report two novel occurrences of R. obtusus in the headwaters of the Brushy Creek system in the Black Warrior River drainage including a singleton and a large population. The ...


Life-History Aspects Of Chrosomus Oreas (Mountain Redbelly Dace) In Catawba Creek, Virginia, Dezarai Thompson, Shelby Hargrave, Gregory Morgan, Steven L. Powers Sep 2017

Life-History Aspects Of Chrosomus Oreas (Mountain Redbelly Dace) In Catawba Creek, Virginia, Dezarai Thompson, Shelby Hargrave, Gregory Morgan, Steven L. Powers

Southeastern Fishes Council Proceedings

Life-history aspects of Chrosomus oreas, Mountain Redbelly Dace, were identified using specimens collected monthly from Catawba Creek in Roanoke County, Virginia. Chrosomus oreas were found in depths up to 63.3 cm with a modest relationship between abundance and depth. The largest specimen examined was a female 64.68 mm standard length, 4.80 g eviscerated weight, and 36 months of age. The oldest specimens examined were 37 months of age suggesting a maximum lifespan of approximately three years. Spawning appears to occur from April to early July, with a mean of 243 oocytes (SD = 178) up to 1.61 ...


Effects Of Mycorrhizal Fungi On Vigna Radiata Growth In Soil Differing In Fertilizer Concentration, Ming Sum Jessica Cheng Jun 2017

Effects Of Mycorrhizal Fungi On Vigna Radiata Growth In Soil Differing In Fertilizer Concentration, Ming Sum Jessica Cheng

Pursuit - The Journal of Undergraduate Research at the University of Tennessee

Mycorrhizal fungi form mutualistic relationships with the roots of some plants, allowing the plant access to nutrients and minerals while the fungi obtain food from the plant. Given that this relationship is beneficial to the plant, this paper investigates the nature of the impact of presence of mycorrhizal fungi on the growth of Vigna radiata (mung beans) in soil of differing chemical environments. Through comparing the stem lengths of plants seven days after germination, it is found that in soil with 0.0% fertilizer, the presence of locally collected, unclassified mycorrhizal fungi impacts the growth of Vigna radiata negatively; in ...


Effects Of Language Immersion Versus Classroom Exposure On Advanced French Learners: An Erp Study, Alexandra Claire Brito Jun 2017

Effects Of Language Immersion Versus Classroom Exposure On Advanced French Learners: An Erp Study, Alexandra Claire Brito

Pursuit - The Journal of Undergraduate Research at the University of Tennessee

University students often report making significant advances in their second language (L2) ability after immersion in a nonnative language through study abroad. The degree to which late L2 learners can become nativelike in terms of L2 performance and brain processing is unclear in second language acquisition research. The link between L2 proficiency and learning context has been characterized in previous research, yet the role of learning experience in attaining nativelike brain processing of L2 remains to be elucidated. This study contrasts learners with advanced French proficiency who have attained this level with no, little, or more immersion experience through study ...


Reproductive Schedule Of The Silver Shiner (Notropis Photogenis) In The Flint River Of Alabama, Kelly Hodgskins, Stephanie Greenleaf, Jonathan Hillman, Bruce Stallsmith Oct 2016

Reproductive Schedule Of The Silver Shiner (Notropis Photogenis) In The Flint River Of Alabama, Kelly Hodgskins, Stephanie Greenleaf, Jonathan Hillman, Bruce Stallsmith

Southeastern Fishes Council Proceedings

Many river-dwelling species of fish are dependent upon and stimulated by fluctuations in river flow for successful reproduction. This is especially true of pelagophils, a reproductive guild whose eggs and larvae require free drifting on river currents for several days. Notropis photogenis (Silver Shiner) is a rheophilic species with a broad distribution from Ontario to the southeastern United States including northern tributaries to the Tennessee River in Alabama. Little is known of its reproductive biology. The purpose of this study was to describe aspects of reproductive biology such as timing and pattern of ovarian development and oocyte maturation of N ...


Intensive, Regular Sampling And Removal Of Modest Numbers Of Fishes Shows No Measurable Impact On Fish Populations In Three Streams Of North Georgia, Steven L. Powers Oct 2016

Intensive, Regular Sampling And Removal Of Modest Numbers Of Fishes Shows No Measurable Impact On Fish Populations In Three Streams Of North Georgia, Steven L. Powers

Southeastern Fishes Council Proceedings

Recent publications and restrictions on collecting by state fish and game managers indicate a growing concern regarding the impact of field sampling on native fish populations. To evaluate the validity of these concerns, data from five life-history studies conducted in Cherokee County, Georgia were examined to test the hypothesis that regular sampling has a negative impact on fish populations. Number of individuals collected was divided by time collecting to calculate catch per unit effort (CPUE) as an indicator of relative abundance for each species. The collecting sequence (i.e. the number of times a species had previously been sampled) was ...


Assessment Of Genetic Diversity And Hybridization For The Endangered Conasauga Logperch (Percina Jenkinsi), Gregory R. Moyer, Anna L. George, Patrick L. Rakes, J.R. Shute, Ashantye' S. Williams Dec 2015

Assessment Of Genetic Diversity And Hybridization For The Endangered Conasauga Logperch (Percina Jenkinsi), Gregory R. Moyer, Anna L. George, Patrick L. Rakes, J.R. Shute, Ashantye' S. Williams

Southeastern Fishes Council Proceedings

The Conasauga logperch, Percina jenkinsi is one of the rarest darters in North America afforded protection under the Endangered Species Act. Unfortunately, little is known about potential threats to the genetic diversity of this species, a narrow endemic. Loss of genetic diversity, spawning of closely related individuals, and hybridization with closely related congeners have been known to increase the rate of extinction for threatened or endangered taxa. We evaluated these risks by estimating and comparing levels of genetic diversity between P. jenkinsi and P. kathae (a closely related, morphologically similar, and more abundant congener) using twelve microsatellite loci. Specifically, we ...


Reproductive Timing Of Erimystax Insignis (Blotched Chub) In The Flint River Of North Alabama, Bruce Stallsmith, Josh Mann, Candice Allen Jul 2015

Reproductive Timing Of Erimystax Insignis (Blotched Chub) In The Flint River Of North Alabama, Bruce Stallsmith, Josh Mann, Candice Allen

Southeastern Fishes Council Proceedings

Important details of the reproductive ecology of many freshwater fishes of the species-rich southeastern United States are still poorly known. One such species is Erimystax insignis (Blotched Chub), whose range includes the Tennessee River drainage in northern Alabama, USA. To determine timing and patterns of reproductive effort, collections were made monthly of as many as 30 individuals from August 2011 through July 2012 from a 14 km stretch of the Flint River in Madison County, Alabama. Female and male gonadosomatic index (GSI) and ovarian development data indicate that reproductive activity for the species peaks from March through May. Ripe and ...


New Upstream Records For Fishes Following Dam Removal In The Cahaba River, Alabama, Micah G. Bennett, J. Heath Howell, Bernard R. Kuhajda, Paul L. Freeman Apr 2015

New Upstream Records For Fishes Following Dam Removal In The Cahaba River, Alabama, Micah G. Bennett, J. Heath Howell, Bernard R. Kuhajda, Paul L. Freeman

Southeastern Fishes Council Proceedings

Population fragmentation by dams of all sizes is a major threat to biodiversity in running waters. Dam removal has become an increasingly popular tool among conservation practitioners because of its potential benefits to aquatic organisms and ecosystems. During fish monitoring following removal of a small run-of-river dam on the Cahaba River, we documented new upstream records between 8 months and 2 years post-removal for five species: Stargazer Shiner, Notropis uranoscopus; River Redhorse, Moxostoma carinatum; Southern Sand Darter, Ammocrypta meridiana; Freckled Darter, Percina lenticula; River Darter, P. shumardi. These new records suggest that the former dam may have served as a ...


Fishes Of The Choctawhatchee River System In Southeastern Alabama And Northcentral Florida, Thomas P. Simon, Charles C. Morris, Bernard R. Kuhajda, Carter R. Gilbert, Henry L. Bart Jr., Nelson Rios, Paul M. Stewart, Thomas P. Simon Iv, Mitt Denney Jan 2015

Fishes Of The Choctawhatchee River System In Southeastern Alabama And Northcentral Florida, Thomas P. Simon, Charles C. Morris, Bernard R. Kuhajda, Carter R. Gilbert, Henry L. Bart Jr., Nelson Rios, Paul M. Stewart, Thomas P. Simon Iv, Mitt Denney

Southeastern Fishes Council Proceedings

The diversity and distribution of fish species occurring in the Choctawhatchee River drainage in southeastern Alabama and northcentral Florida were surveyed to obtain historical baseline information. Three hundred seventy-four sites were evaluated for species diversity and distribution in the drainage, including compilation of unpublished records from southeastern natural history museums. The greatest diversity at any single site was 37 species. Sixty-eight sites were represented by 15 species or more, and 26 sites were represented by a single species. The most frequently encountered species includes Gambusia holbrooki, Percina nigrofasciata, Esox americanus, Notropis texanus, Lepomis macrochirus, Cyprinella n. sp. cf venusta, Notropis ...


Fty720 (Fingolimod) Provides Insight Into The Molecular Mechanisms Of Multiple Sclerosis, Madelyn Elizabeth Crawford Jun 2014

Fty720 (Fingolimod) Provides Insight Into The Molecular Mechanisms Of Multiple Sclerosis, Madelyn Elizabeth Crawford

Pursuit - The Journal of Undergraduate Research at the University of Tennessee

Multiple sclerosis (MS) is a neurodegenerative disorder caused by a prolonged immune- mediated inflammatory response that targets myelin. Nearly all of the drugs approved for the treatment of MS are general immunosuppressants or only function in symptom management. The oral medication fingolimod, however, is reported to have direct therapeutic effects on cells of the central nervous system in addition to immunomodulatory functions. Fingolimod is known to interact with sphingosine-1-phosphate (S1P) receptors, and the most widely- accepted theory for its mechanism of action is functional antagonism of the receptor. This review examines significant neuromodulatory effects achieved by functional antagonism of the ...


At The Heart Of The Matter: Reading Contracts And Dealing With Risk, Tina L. Stark Jun 2013

At The Heart Of The Matter: Reading Contracts And Dealing With Risk, Tina L. Stark

Transactions: The Tennessee Journal of Business Law

No abstract provided.


Improving Codon Evolution Models Using Complex Mutation Models, Preston Hewgley Mar 2013

Improving Codon Evolution Models Using Complex Mutation Models, Preston Hewgley

Pursuit - The Journal of Undergraduate Research at the University of Tennessee

This paper discusses an improvement in a Stochastic Evolutionary Model of Protein Production Rate (SEMPPR) by revising the method by which it models mutation. SEMPPR previously assumed unbiased mutation, an assumption whose inaccuracy is made clear by observed codon counts of low-expression genes, where mutation determines equilibrium state. This paper presents a new, more complex model generalized on a per-codon basis and calculated from observed codon frequencies using a maximum likelihood framework. Results obtained from SEMPPR using the codon specific mutation model proved more accurate in predicting a protein’s production rate, reaffirming that complex mechanisms govern codon mutation rates.


Metabolic Rescue Of “Glucose Addicted” Cancer Cells In Vitro, Paolo Vignali Mar 2013

Metabolic Rescue Of “Glucose Addicted” Cancer Cells In Vitro, Paolo Vignali

Pursuit - The Journal of Undergraduate Research at the University of Tennessee

Transformations in the glycolytic metabolism of neoplasms modulate their robust cellular division. This characteristic leads to an “addiction” to glucose for continued proliferation and viability. This study investigated whether glucose metabolites could rescue cellular viability in glucose-starvation conditions, a model of the inter-tumoral nutrient-deficient environment. Findings illustrated potential cellular viability rescue with pyruvate addition in glucose-deprived conditions, yet the same potential was not observed with lactic acid, a metabolite that exists at characteristically high concentrations within the intertumoral microenvironment. These results could implicate a predominance of certain metabolic pathways in nutrient-starved cells. Molecular transport capacities across plasma membranes are tied ...


Front Matter, Southeastern Fishes Council Jan 2013

Front Matter, Southeastern Fishes Council

Southeastern Fishes Council Proceedings

No abstract provided.


Reproductive Biology Of The Frecklebelly Darter, Percina Stictogaster (Teleostei: Percidae), David J. Eisenhour, Audrey M. Richter, Lynn V. Eisenhour, Carol-Rose Gingras Jan 2013

Reproductive Biology Of The Frecklebelly Darter, Percina Stictogaster (Teleostei: Percidae), David J. Eisenhour, Audrey M. Richter, Lynn V. Eisenhour, Carol-Rose Gingras

Southeastern Fishes Council Proceedings

No abstract provided.