Life Sciences Commons^™

Characterizing Endothelial Notch1 Release In Response To Changes In Vascular Wall Shear Stress, Matthew Indiana Badour

Electronic Theses and Dissertations

Murine and cell culture models have identified Notch1 as a novel endothelial mechanosensor that may exert a protective role for vascular adjustments in response to changes in vascular wall shear stress. However, in vivo studies in humans are lacking. Accordingly, we sought to characterize the concentrations of Notch1 extracellular domain (ECD) prior to, during, and following 20-min of altered shear stress in the brachial artery of ten young and healthy adults (6M/4F). Alterations in shear were induced by placing a pneumatic cuff inflated to 220mmHg around the left wrist. Cuffs were also placed below the axilla of both arms and …

Hand-Arm Vibration Exposure In Drummers, Dylan Durward

Electronic Theses and Dissertations

Due to the physically intense nature of the activity, drummers (i.e., percussionists who play the drum set) are exposed to a variety of factors, including hand-arm vibration (HAV), that put them at increased risk of developing playing-related musculoskeletal disorders (PRMDs). The purpose of this study was to examine HAV exposure in drummers through realistic playing scenarios. Specifically, this study examined vibrations (i.e., frequency-weighted RMS accelerations) recorded at the hands. Six male drummers played three songs of their choosing with one accelerometer placed on the right hand, then repeated the same three songs with the accelerometer placed on the left hand …

An Investigation Of Drummers’ Trunk And Upper Limb Muscle Activation Profiles During High-Velocity Cymbal Crashes, Nicolas Latreille

Electronic Theses and Dissertations

Drumming is a physically demanding activity, and skilled drummers share many physical and cognitive attributes with elite athletes. The “double pulse” muscle activation (DPMA) pattern is a motor control strategy that has been observed in athletes of sports involving ballistic movements, such as baseball, golf, and elite Mixed Martial Arts fighters. The two pulses are believed to function to increase striking velocity and effective mass, thus increasing force transfer onto the target. The purpose of this study was to examine the muscle activation patterns of highly skilled drummers for evidence of a DPMA during high-velocity cymbal crashes. Three highly skilled …

Elucidating Mechanisms For S-Nitrosoglutathione Reductase Activity And Control In Plants Using O-Aminobenzoyl-S-Nitrosoglutathione And A Novel Photo-Sensitive Probe, Leslie Ventimiglia

Electronic Theses and Dissertations

S-nitrosoglutathione reductase, (GSNOR) is widely accepted as the master regulator of stress through NO signaling and protein S-nitrosylation. GSNOR mediates stress response through the catalysis of its principal substrate S-nitrosoglutathione (GSNO). The instigation of various stressors in plants cause observable changes in plant phenotype, which are associated with changes in GSNOR activity. There are no current methods for measuring GSNOR activity directly in living plants. In this paper, a previously developed fluorogenic pseudo-substrate for human GSNOR, OAbz-GSNO, was applied to the Solanum lycopersicum plant model. OAbz-GSNO was identified as a promising novel pseudo- substrate to study changes …

Studies Of Chemosensory Responses In The Pharynx Of The Sea Lamprey (Petromyzon Marinus), Hasan Huseyin Polat

Electronic Theses and Dissertations

The sea lamprey is a basal vertebrate, and the oldest extant species with taste buds. The objective of this thesis was to study the chemosensory responses from the sea lamprey’s pharynx, which is located caudal to oral cavity and medial to seven lateral brachiopores. The pharynx contains taste buds that detect and respond to tastants to inform lampreys about gustatory factors in the environment. The location of these taste buds along the lateral surface of the pharynx was first determined using scanning electron microscopy. Then using electrophysiology, our recordings from these pharyngeal regions containing taste buds picked up responses from …

The Design And Testing Of Fluorescence-Based Sensors For Phosphate And Phosphonate, Sara Hassanzadehroknabadi

Electronic Theses and Dissertations

Inorganic phosphate (Pi) is an essential compound for all living things, as it serves as a component of nucleic acids and ATP, which are required for plant growth and proliferation. However, when excess Pi enters the aquatic environment, it has severe detrimental effects through the induction of harmful algal blooms (HAB), which negatively impact aquatic life, the quality of drinking water as well as recreational activities. It is therefore critical to have fast, sensitive, and inexpensive sensors for Pi that quickly and quantitively measure its concentration in a field setting.

Phosphonates or organophosphorus compounds are phosphoric acids possessing alkyl or …

Structure And Mechanics Of Biomembrane Mimics In The Presence Of Vitamin E, Mitchell Dipasquale

Electronic Theses and Dissertations

Over the course of this dissertation, the fundamental behaviours and interactions between various analogs of vitamin E and biologically-relevant membranes will be explored. These analogs include the biologically active form, α-tocopherol; the most naturally abundant form γ-tocopherol; an oxidized product, α-tocopheryl quinone; and the synthetic stabile form, vitamin E acetate.

Beginning in Chapter 1, a foundation in membrane biophysics is established from a historical progression of the field. The importance of biomembranes is argued and a deep connection is established between structure and function. Key structural features of lipid assemblies, and role of lipid composition is defined, and with the …

Mother Knows Best: Mechanistic Aspects Of Foraging Preference And Differential Arrestment Of Gravid Females: A Case Study On Blow Flies (Diptera: Calliphoridae), Vanessa Elizabeth Owen

Electronic Theses and Dissertations

Behavioural plasticity is a concept that describes a change in an organism’s behaviour due to their exposure to stimuli that differ from their usual environment. For instance, females of many insect species alter their behavioural responses when exposed to differing substances that they utilize for feeding, oviposition, and/or mating. Behaviours such as the frequency of walking, tasting, grooming exhibited by flies can be associated with the detection and acceptance of a suitable medium. For this thesis, the arrestment and behavioural response of gravid adult females of three species of blow flies (Diptera: Calliphoridae), Lucilia sericata Meigen, Phormia regina Meigen, and …

The Bouba/Kiki Effect On Gendered Objects In The Arabic Language, Ghadir Nassereddine

Electronic Theses and Dissertations

People are more likely to associate the nonword bouba with a round shape, and kiki with a sharp shape, an effect known as the Bouba/Kiki effect (BK) (Ramachandran & Hubbard, 2001). Relatedly, female names are associated with a round shape whereas male names are associated with a sharp shape (Sidhu & Pexman, 2015) and this effect extends to grammatically gendered nonwords in French (Sidhu, Pexman, & Saint-Aubin, 2019). These associations have not been examined in Arabic, or with real words with a grammatical gender. The present study addresses this gap by examining the influences of letter sound …