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Regulation Of Type 1 Diabetes By A Self-Mhc Class Ii Peptide: Role Of Transforming Growth Factor Beta (Tgf-Beta)., Bhagirath Singh, R Mukherjee, P Chaturvedi, Babita Agrawal
Regulation Of Type 1 Diabetes By A Self-Mhc Class Ii Peptide: Role Of Transforming Growth Factor Beta (Tgf-Beta)., Bhagirath Singh, R Mukherjee, P Chaturvedi, Babita Agrawal
Microbiology & Immunology Publications
The present study was undertaken to analyze the regulatory T cells generated in response to class I derived self-I-A beta(g7) (54-76) peptide. It was observed T cells from young unprimed type 1 diabetes (T1D) prone NOD mice did not respond to self-I-A beta(g7) (54-76) peptide although T cells from primed young NOD mice showed a strong response. T cells from young unprimed BALB/c mice responded to self-I-A beta(d) (62-78) peptide. However, a breakdown of tolerance to these peptides was observed with age in both the strains. Culture supernatant from I-A beta(g7) (54-76) peptide-primed cells secreted large amounts of TGF-beta and …