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Articles 151 - 163 of 163
Full-Text Articles in Life Sciences
Pparα And Pparγ Activation Is Associated With Pleural Mesothelioma Invasion But Therapeutic Inhibition Is Ineffective, M. Lizeth Orozco Morales, Catherine A. Rinaldi, Emma De Jong, Sally M. Lansley, Joel P. A. Gummer, Bence Olasz, Shabarinath Nambiar, Danika E. Hope, Thomas H. Casey, Y. C. Gary Lee, Connull Leslie, Gareth Nealon, David M. Shackleford, Andrew K. Powell, Marina Grimaldi, Patrick Balaguer, Rachael M. Zemek, Anthony Bosco, Matthew J. Piggott, Alice Vrielink, Richard A. Lake, W. Joost Lesterhuis
Pparα And Pparγ Activation Is Associated With Pleural Mesothelioma Invasion But Therapeutic Inhibition Is Ineffective, M. Lizeth Orozco Morales, Catherine A. Rinaldi, Emma De Jong, Sally M. Lansley, Joel P. A. Gummer, Bence Olasz, Shabarinath Nambiar, Danika E. Hope, Thomas H. Casey, Y. C. Gary Lee, Connull Leslie, Gareth Nealon, David M. Shackleford, Andrew K. Powell, Marina Grimaldi, Patrick Balaguer, Rachael M. Zemek, Anthony Bosco, Matthew J. Piggott, Alice Vrielink, Richard A. Lake, W. Joost Lesterhuis
Research outputs 2022 to 2026
Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath. We compared cell lines injected either subcutaneously or intrapleurally and found that only the latter resulted in invasive and rapid growth. Pleural tumors displayed a transcriptional signature consistent with increased activity of nuclear receptors PPARα and PPARγ and with an increased abundance of endogenous PPAR-activating ligands. We found that chemical probe GW6471 is a potent, dual PPARα/γ antagonist with anti-invasive and anti-proliferative activity in vitro. However, administration of GW6471 at doses that provided sustained plasma …
Ranging Patterns And Site Fidelity Of Snubfin Dolphins In Yawuru Nagulagun/Roebuck Bay, Western Australia, Alexandra D’Cruz, Chandra Salgado Kent, Kelly Waples, Alexander M. Brown, Sarah A. Marley, Deborah Thiele, Holly C. Raudino, Yawuru Native Title Prescribed Body Corporate, Broome, Wa, Australia
Ranging Patterns And Site Fidelity Of Snubfin Dolphins In Yawuru Nagulagun/Roebuck Bay, Western Australia, Alexandra D’Cruz, Chandra Salgado Kent, Kelly Waples, Alexander M. Brown, Sarah A. Marley, Deborah Thiele, Holly C. Raudino, Yawuru Native Title Prescribed Body Corporate, Broome, Wa, Australia
Research outputs 2022 to 2026
For long-lived species such as marine mammals, having sufficient data on ranging patterns and space use in a timescale suitable for population management and conservation can be difficult. Yawuru Nagulagun/Roebuck Bay in the northwest of Western Australia supports one of the largest known populations of Australian snubfin dolphins (Orcaella heinsohni)—a species with a limited distribution, vulnerable conservation status, and high cultural value. Understanding the species’ use of this area will inform management for the long-term conservation of this species. We combined 11 years of data collected from a variety of sources between 2007 and 2020 to assess the ranging patterns …
Navigating Loss And Value Trade-Offs In A Changing Climate, Karen Paiva Henrique, Petra Tschakert, Chantal Bourgault Du Coudray, Pierre Horwitz, Kai Daniel Christian Krueger, Alexander James Wheeler
Navigating Loss And Value Trade-Offs In A Changing Climate, Karen Paiva Henrique, Petra Tschakert, Chantal Bourgault Du Coudray, Pierre Horwitz, Kai Daniel Christian Krueger, Alexander James Wheeler
Research outputs 2022 to 2026
Climate change puts at risk what people value in their everyday lives, with evidence of harm and suffering already taking place across all regions of the world. As societies slowly come to grips with the possibility of not being able to save everything that is valued, there is an urgent need to identify what is most important for individuals and groups, to prioritise action and prevent or minimise intolerable losses. Yet, people's priorities vary greatly; individual choices are contingent on what people hold dear in the places they inhabit, which in turn is shaped by their positioning in society and …
Predicting Climate-Sensitive Water-Related Disease Trends Based On Health, Seasonality And Weather Data In Fiji, Sarah Nelson, Aaron Jenkins, Stacy D. Jupiter, Pierre Horwitz, Sangeeta Mangubhai, Seye Abimbola, Anaseini Ratu, Timoci Naivalulevu, Joel Negin
Predicting Climate-Sensitive Water-Related Disease Trends Based On Health, Seasonality And Weather Data In Fiji, Sarah Nelson, Aaron Jenkins, Stacy D. Jupiter, Pierre Horwitz, Sangeeta Mangubhai, Seye Abimbola, Anaseini Ratu, Timoci Naivalulevu, Joel Negin
Research outputs 2022 to 2026
Leptospirosis, typhoid and dengue are three water-related diseases influenced by environmental factors. We examined whether seasonality and rainfall predict reported syndromes associated with leptospirosis, typhoid and dengue in Fiji. Poisson generalised linear models were fitted with s6 early warning, alert and response system (EWARS) syndromic conditions from March 2016 until December 2020, incorporating seasonality, temperature and rainfall. Watery diarrhoea, prolonged fever and suspected dengue displayed seasonal trends with peaks corresponding with the rainy season, while bloody diarrhoea, acute fever with rash and acute jaundice syndrome did not. Seasonality was the most common predictor for watery and bloody diarrhoea, prolonged fever, …
Environmentally Friendly Agent Against Fall Armyworm (Spodoptera Frugiperda): Antifeedant Potency Of Mentha Spicata Aqueous Extracts, Emmanuel Peprah-Yamoah, Ebenezer Afrifa-Yamoah, Hayford Ofori, Eric Adua
Environmentally Friendly Agent Against Fall Armyworm (Spodoptera Frugiperda): Antifeedant Potency Of Mentha Spicata Aqueous Extracts, Emmanuel Peprah-Yamoah, Ebenezer Afrifa-Yamoah, Hayford Ofori, Eric Adua
Research outputs 2022 to 2026
The rising trends of insect resistance, coupled with escalating environmental pollution from synthetic pesticides, heighten the need for a more effective and, non-hazardous agents to control insect/pests. Different aqueous extracts of Mentha spicata were screened for their phytochemical constituents and their antifeedant activities against Spodoptera frugiperda. Screening of the different aqueous extracts of Mentha spicata obtained by cold maceration revealed the presence of phenolics and tannins. The concentration of phenols and tannins in the water, glycerine, and glycerine plus water (glycerine-water) extracts were significantly different (p < 0.05). Mentha spicata water extract had a greater antifeedant activity against Spodoptera frugiperda as compared to glycerine and glycerine-water (60 : 40, v/v) extracts at a concentration of 5g/100 mL. The estimated % antifeedant activity recorded were 97 as against 8.21 and 49.81, respectively. Aqueous neem seed water extracts gave an estimated % antifeedant activity of 93.07 and it served as a control. Saponins were absent in all extracts and only water extracts had alkaloids present. The simple, non-hazardous, and cost-saving extraction method demonstrated could be applied in both commercial and subsistent farming to counteract the damnable effects of Spodoptera frugiperda infestation.
Patch Dynamics Driven By Wave Exposure In Subtidal Temperate Seaweeds Are Exacerbated By Warming Oceans, Yannick Mulders, Lydiane Mattio, Julia C. Phillips, Paul S. Lavery, Gary A. Kendrick, Thomas Wernberg
Patch Dynamics Driven By Wave Exposure In Subtidal Temperate Seaweeds Are Exacerbated By Warming Oceans, Yannick Mulders, Lydiane Mattio, Julia C. Phillips, Paul S. Lavery, Gary A. Kendrick, Thomas Wernberg
Research outputs 2022 to 2026
Over the past decades, ocean temperatures have been steadily increasing and are projected to continue to do so, stressing many temperate marine organisms. Changing temperatures do not affect ecosystems in isolation, but interact with many other factors in shaping ecological communities. We investigated the changes over 2 decades in subtidal temperate seaweed communities over a wave exposure gradient in Western Australia, a global warming hotspot. We found higher diversity in the seaweed community and a higher proportion of biomass of species with a warm affinity (expressed as the tropicalization index: TI) over time. There was no decline in biomass of …
Editorial: Fire Regimes In Desert Ecosystems: Drivers, Impacts And Changes, Eddie J. B. Van Etten, Matthew L. Brooks, Aaron C. Greenville, Glenda M. Wardle
Editorial: Fire Regimes In Desert Ecosystems: Drivers, Impacts And Changes, Eddie J. B. Van Etten, Matthew L. Brooks, Aaron C. Greenville, Glenda M. Wardle
Research outputs 2022 to 2026
Although not commonly associated with fire, many desert ecosystems across the globe do occasionally burn, and there is evidence that fire incidences are increasing, leading to altered fire regimes in this biome. The increased prevalence of megafires (wildfires > 10,000 ha in size and typically damaging) in most global biomes is linked to climate change, although those occurring in deserts have received far less attention, from both a research and policy perspective, than that of forested ecosystems (Linley et al., 2022). Understanding the drivers of desert fires, from climate to landscape patterns of hydrology and soil, and how these may be …
Evaluation Of Virtual Screening Strategies For The Identification Of Γ-Secretase Inhibitors And Modulators, Alicia Ioppolo, Melissa Eccles, David Groth, Giuseppe Verdile, Mark Agostino
Evaluation Of Virtual Screening Strategies For The Identification Of Γ-Secretase Inhibitors And Modulators, Alicia Ioppolo, Melissa Eccles, David Groth, Giuseppe Verdile, Mark Agostino
Research outputs 2022 to 2026
γ-Secretase is an intramembrane aspartyl protease that is important in regulating normal cell physiology via cleavage of over 100 transmembrane proteins, including Amyloid Precursor Protein (APP) and Notch family receptors. However, aberrant proteolysis of substrates has implications in the progression of disease pathologies, including Alzheimer’s disease (AD), cancers, and skin disorders. While several γ-secretase inhibitors have been identified, there has been toxicity observed in clinical trials associated with non-selective enzyme inhibition. To address this, γ-secretase modulators have been identified and pursued as more selective agents. Recent structural evidence has provided an insight into how γ-secretase inhibitors and modulators are recognized …
Connectivity Shapes Functional Diversity And Maintains Complementarity In Surf Zones On Exposed Coasts, Christopher J. Henderson, Ben L. Gilby, Andrew D. Olds, Jesse Mosman, Rod M. Connolly, Glenn Hyndes, Brendan Kelaher, Brooke Maslo, Alan Williams, Thomas A. Schlacher
Connectivity Shapes Functional Diversity And Maintains Complementarity In Surf Zones On Exposed Coasts, Christopher J. Henderson, Ben L. Gilby, Andrew D. Olds, Jesse Mosman, Rod M. Connolly, Glenn Hyndes, Brendan Kelaher, Brooke Maslo, Alan Williams, Thomas A. Schlacher
Research outputs 2022 to 2026
Habitat complexity and connectivity can influence the number of species and their diversity across a landscape. For the surf zones of ocean-exposed beaches, globally one of the longest habitat interfaces, the assumed low structural complexity, and apparent homogeneity, of the sandy seafloor habitats predicts low taxonomic and functional diversity. Here, we assessed how the configuration of the seascape and the context of different beach structure functional diversity and functional niche space of fish assemblages in surf zones. We expected that beaches that were well connected with highly productive and complex estuarine and reef habitats would support a greater level of …
Do Bird Communities Differ With Post-Fire Age In Banksia Woodlands Of South-Western Australia?, Robert A. Davis, Leonie E. Valentine, Michael D. Craig
Do Bird Communities Differ With Post-Fire Age In Banksia Woodlands Of South-Western Australia?, Robert A. Davis, Leonie E. Valentine, Michael D. Craig
Research outputs 2022 to 2026
Prescribed fire is a widespread management practice in fire-prone ecosystems that can have significant effects on fauna. To inform the development of appropriate prescribed burning regimes, we explored bird responses to time since fire in threatened Banksia woodlands in south-western Australia. We used area searches to estimate bird densities on 20 plots ranging from 1 to 26 years post fire. Fire had no significant effect on the overall bird community or any foraging guilds and there was no clear post-fire succession. Of the 26 frequently occurring species analysed, only two showed responses to fire, with yellow-rumped thornbills more abundant in …
Bioturbation By Echidna (Tachyglossus Aculeatus) In A Forest Habitat, South-Western Australia, Shannon J. Dundas, Lara Osborne, Anna J. M. Hopkins, Katinka X. Ruthrof, Patricia A. Fleming
Bioturbation By Echidna (Tachyglossus Aculeatus) In A Forest Habitat, South-Western Australia, Shannon J. Dundas, Lara Osborne, Anna J. M. Hopkins, Katinka X. Ruthrof, Patricia A. Fleming
Research outputs 2022 to 2026
Bioturbation by digging animals is important for key forest ecosystem processes such as soil turnover, decomposition, nutrient cycling, water infiltration, seedling recruitment, and fungal dispersal. Despite their widespread geographic range, little is known about the role of the short-beaked echidna (Tachyglossus aculeatus) in forest ecosystems. We measured the density and size of echidna diggings in the Northern Jarrah Forest, south-western Australia, to quantify the contribution echidna make to soil turnover. We recorded an overall density of 298 echidna diggings per hectare, 21 % of which were estimated to be less than 1 month old. The average size of digs was …
Sinking Seaweed In The Deep Ocean For Carbon Neutrality Is Ahead Of Science And Beyond The Ethics, Aurora M. Ricart, Dorte Krause-Jensen, Kasper Hancke, Nichole N. Price, Pere Masqué, Carlos M. Duarte
Sinking Seaweed In The Deep Ocean For Carbon Neutrality Is Ahead Of Science And Beyond The Ethics, Aurora M. Ricart, Dorte Krause-Jensen, Kasper Hancke, Nichole N. Price, Pere Masqué, Carlos M. Duarte
Research outputs 2022 to 2026
Sinking vast amounts of seaweed in the deep ocean is currently being proposed as a promising ocean carbon dioxide removal strategy as well as a natural-based solution to mitigate climate change. Still, marketable carbon offsets through large-scale seaweed sinking in the deep ocean lack documentation and could involve unintended environmental and social consequences. Managing the risks requires a number of urgent actions.
Tropicalization Of Seagrass Macrophytodetritus Accumulations And Associated Food Webs, Gilles Lepoint, Glenn A. Hyndes
Tropicalization Of Seagrass Macrophytodetritus Accumulations And Associated Food Webs, Gilles Lepoint, Glenn A. Hyndes
Research outputs 2022 to 2026
Seagrass, systems export significant amounts of their primary production as large detritus (i.e. macrophytodetritus). Accumulations of exported macrophytodetritus (AEM) are found in many areas in coastal environment. Dead seagrass leaves are often a dominant component of these accumulations, offering shelter and/or food to numerous organisms. AEM are particular habitats, different from donor habitats (i.e. seagrass meadow, kelp or macroalgae habitats) and with their own characteristics and dynamics. They have received less attention than donor habitats despite the fact they often connect different coastal habitats, are the place of intense remineralization processes and shelter associated detritus food web. As for seagrass …