Life Sciences Commons^™

Autoradiographic Localization Of Exogenously Supplied Amino Acids After Uptake By The Polychaete, Glycera Dibranchiata Ehlers, Paul Chien, Michael Rice

Michael A Rice

Localization of amino acid transport sites within the integument of Glycera dibranchiata Ehlers was carried out by freeze-section and freeze-dry histological techniques. The worms were exposed for one hour to the non-metabolizable amino acid analog c(14)-cycloleucine in seawater. Freeze-sectioning and freeze drying of tissue samples allows the localization of water soluble compounds by autoradiography. Amino acid uptake is largely across the parapodial gill surfaces and the epidermis. The gills become rapidly labelled with c(14)-cycloleucine to a greater extent than the epidermal cell layers. Coelomocytes within the gills become radiolabeled in one hour. It is suggested that the rapid labelling of …

Corn Response To Sulfur On Illinois Soils, R. G. Hoeft, J. E. Sawyer, R. M. Vanden Heuvel, M. A. Schmitt, G. S. Brinkman

John E. Sawyer

Collagen Fibril Formation Sds.Pdf, George W. Dombi, Brian H. Halsall

George Dombi

No abstract provided.

Molecular Mechanisms Underlying Skeletal Muscle Weakness In Human Cancer: Reduced Myosin-Actin Cross-Bridge Formation And Kinetics, Michael Jj. Toth, Mark S. Miller, Damien M. Callahan, Andrew P. Sweeny, Ivette Nunez, Steven M. Grunberg, Hirak Der-Torossian, Marion E. Couch, Kim Dittus

Mark S. Miller

PHYSICAL FUNCTION DETERIORATES substantially following a diagnosis of cancer (3, 48), and patients view this decline as one of the most distressing side effects of the disease, more so than classic side effects such as pain, nausea, and vomiting (13, 60). Functional disability can be the impetus for dose reduction or cessation of anticancer treatments and predicts chemotherapy toxicity and survival (12, 30, 33, 39). Our current understanding of the factors contributing to reduced functional capacity in patients with cancer is, however, severely limited. Physiological changes that occur within the skeletal muscle of patients with cancer can contribute to functional …

Skeletal Muscle Mitochondrial Density, Gene Expression, And Enzyme Activities In Human Heart Failure: Minimal Effects Of The Disease And Resistance Training, Michael J. Toth, Mark S. Miller, Kimberly A. Ward, Philip A. Ades

Mark S. Miller

IMPAIRED SKELETAL MUSCLE ENERGETICS in heart failure (HF) patients (32) may contribute to physical disability and metabolic dysfunction. Decreased skeletal muscle oxidative capacity (63), secondary to reduced mitochondrial density (12, 13) and/or function (10, 36, 52), may contribute to exercise intolerance, the hallmark symptom of HF. Moreover, as mitochondrial dysfunction is associated with fiber atrophy (7), impaired energetics may reduce physical function by promoting muscle wasting and, in turn, weakness (21). Because mitochondrial dysfunction has been implicated in the pathophysiology of diabetes (41), alterations in mitochondrial content and/or function could also contribute to the high prevalence of insulin resistance in …

Cognitive Coordinate Systems: Accounts Of Mental Rotation And Individual Differences In Spatial Ability, Marcel Adam Just, Patricia A. Carpenter

Marcel Adam Just

No abstract provided.

Chronic Heart Failure Reduces Akt Phosphorylation In Human Skeletal Muscle: Relationship To Muscle Size And Function, Michael J. Toth, Kimberly Ward, Jos Van Der Velden, Mark S. Miller, Peter Vanburen, Martin M. Lewinter, Philip A. Ades

Mark S. Miller

HEART FAILURE (HF) is the final common pathway for many chronic cardiac diseases and is presently the only cardiac diagnosis continuing to increase in prevalence in the United States. Patients suffering from HF report high rates of physical disability, as defined by an inability to perform simple daily activities (43). Although the reason for their physical disability is unclear, most research has focused on aerobic exercise intolerance in these patients (23). This is logical considering that the hallmark symptom of HF is exertional dyspnea and because of the widespread use of aerobic capacity as a diagnostic tool (36). Diminished aerobic …