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Articles 1 - 30 of 174
Full-Text Articles in Life Sciences
Pvaast Anallysis Of Alzheimer’S Disease Sequencing Project Pedigree Data, Kristen Crofts, John S. K. Kauwe
Pvaast Anallysis Of Alzheimer’S Disease Sequencing Project Pedigree Data, Kristen Crofts, John S. K. Kauwe
Journal of Undergraduate Research
Alzheimer’s disease is a progressive brain disorder affecting more than 10 percent of Americans over the age of 65 (1). This disease destroys memory and thinking skills and is a leading cause of dementia. Although research in recent years has provided substantial information related to risk factors associated with Alzheimer’s disease, a great deal of information still remains unknown. PVAAST is a software tool that can analyze genome sequence data of Alzheimer’s patients in a creative way by also analyzing the patients’ pedigree information. With the combined information from family members, it is more feasible to identify genetic mutations related …
Acetobacter Fabarum Genes Influencing Drosophila Melanogaster Phenotypes, Kylie Makay White
Acetobacter Fabarum Genes Influencing Drosophila Melanogaster Phenotypes, Kylie Makay White
Theses and Dissertations
Research in our lab has predicted hundreds of bacterial genes that influence nine different traits in the fruit fly, Drosophila melanogaster. As a practical alternative to creating site-directed mutants for each of the predicted genes, we created an arrayed transposon insertion library using a strain of Acetobacter fabarum DsW_054 isolated from fruit flies. Creation of the Acetobacter fabarum DsW_054 gene knock-out library was done through random transposon insertion, combinatorial mapping and Illumina sequencing. Successful mapping of transposon insertion was achieved for 6418 mutants with hits within 63% of annotated genes within Acetobacter fabarum DsW_054. Insertion sites were verified in …
Understanding Community And Ecophysiology Of Plant Species On The Colorado Plateau, Hannah Elizabeth Yokum
Understanding Community And Ecophysiology Of Plant Species On The Colorado Plateau, Hannah Elizabeth Yokum
Theses and Dissertations
The intensification of aridity due to anthropogenic climate change is likely to have a large impact on the growth and survival of plant species in the southwestern U.S. where species are already vulnerable to high temperatures and limited precipitation. Global climate change impacts plants through a rising temperature effect, CO2 effect, and land management. In order to forecast the impacts of global climate change, it is necessary to know the current conditions and create a baseline for future comparisons and to understand the factors and players that will affect what happens in the future. The objective of Chapter 1 is …
Influence Of Epstein-Barr Virus On Systemic Lupus Erythematosus Disease Development And The Role Of Depression On Disease Progression, Caleb Cornaby
Influence Of Epstein-Barr Virus On Systemic Lupus Erythematosus Disease Development And The Role Of Depression On Disease Progression, Caleb Cornaby
Theses and Dissertations
Systemic Lupus Erythematosus (SLE) is an autoimmune disease affecting 20 to 250 individuals per 100,000 worldwide. Symptomology includes dermatological manifestations such as discoid lesions, acute cutaneous rashes, and oral and nasal ulcers, along with musculoskeletal, pulmonary, and renal complications. Abnormal T and B lymphocyte function and apoptosis, immune complex clearance, complement function, and nucleosome processing are typical of disease pathophysiology. SLE is the result of both environmental and genetic factors, which together create the conditions leading to disease onset and progression. Of these environmental factors, Epstein-Barr virus (EBV) infection is known to cause the genesis of cross-reactive antibodies in SLE …
Phosphate Signaling Through Alternate Conformations Of The Pstscab Phosphate Transporter, Ramesh Krishna Vuppada
Phosphate Signaling Through Alternate Conformations Of The Pstscab Phosphate Transporter, Ramesh Krishna Vuppada
Theses and Dissertations
Phosphate is an essential compound for life. Escherichia coli employs a signal transduction pathway that controls the expression of genes that are required for the high-affinity acquisition of phosphate and the utilization of alternate sources of phosphorous. These genes are only expressed when environmental phosphate is limiting. The seven genes for this signaling pathway encode the two-component regulatory proteins PhoB and PhoR, as well as the high-affinity phosphate transporter PstSCAB and an auxiliary protein called PhoU. As the sensor kinase PhoR has no periplasmic sensory domain, the mechanism by which these cells sense environmental phosphate is not known. This paper …
Human-Bear Interactions Among Black Bears In Bryce Canyon National Park, Utah, And Polar Bears On Alaska's North Slope, Wesley G. Larson
Human-Bear Interactions Among Black Bears In Bryce Canyon National Park, Utah, And Polar Bears On Alaska's North Slope, Wesley G. Larson
Theses and Dissertations
Human-bear interactions are an important consideration of bear biology, as interactions can lead to destruction of property as well as injury or death for both human and bear. Successful analysis of why these interactions occur can lead to appropriate preventative measures and mitigation of further conflict. Bryce Canyon National Park (BRCA) is comprised of relatively poor bear habitat, but a black bear population exists on the Paunsaugunt Plateau, on which the park occupies the eastern edge. Park managers expressed interest in learning more about bear movements and, specifically, bear use of anthropogenic features following a number of human-bear incidents located …
Using Remote Cameras To Estimate The Abundance Of Ungulates, Jace C. Taylor
Using Remote Cameras To Estimate The Abundance Of Ungulates, Jace C. Taylor
Theses and Dissertations
Many wildlife populations globally are experiencing unprecedented declines, and without accurate and precise estimates of abundance, we will not be able to conserve these vulnerable species. Remote cameras have rapidly advanced as wildlife monitoring tools and may provide accurate and precise estimates of abundance that improve upon traditional methods. Using remote cameras to estimate abundance may be less expensive, less intrusive, less dangerous, and less time consuming than other methods. While it is apparent that remote cameras have a place in the future of wildlife monitoring, research, and management, many questions remain concerning the proper use of these tools. In …
Response Inhibition To High Calorie Food Cues Among Adolescents Following Active And Sedentary Video Game Play Using A Go/No-Go Task: A Randomized Crossover Study, Joshua L. Smith
Theses and Dissertations
Sedentary behaviors, such as leisure time computer use and sedentary video games, are significant barriers to regular physical activity and contribute to high rates of overweight and obesity among adolescents. Sedentary screen time can adversely affect food intake and food selection. Active video games may be a promising way of increasing daily physical activity levels among adolescents. Active video games may help modulate response inhibition and food intake. PURPOSE: Compare the effects of an acute bout of active and sedentary video gaming on N2 amplitudes (while viewing high calorie and low calorie images), Stroop Color Word Test (Stroop test) performance …
Using Remote Cameras To Estimate The Abundance Of Ungulates, Jace C. Taylor
Using Remote Cameras To Estimate The Abundance Of Ungulates, Jace C. Taylor
Theses and Dissertations
Many wildlife populations globally are experiencing unprecedented declines, and without accurate and precise estimates of abundance, we will not be able to conserve these vulnerable species. Remote cameras have rapidly advanced as wildlife monitoring tools and may provide accurate and precise estimates of abundance that improve upon traditional methods. Using remote cameras to estimate abundance may be less expensive, less intrusive, less dangerous, and less time consuming than other methods. While it is apparent that remote cameras have a place in the future of wildlife monitoring, research, and management, many questions remain concerning the proper use of these tools. In …
Response Inhibition To High Calorie Food Cues Among Adolescents Following Active And Sedentary Video Game Play Using A Go/No-Go Task: A Randomized Crossover Study, Joshua L. Smith
Theses and Dissertations
Sedentary behaviors, such as leisure time computer use and sedentary video games, are significant barriers to regular physical activity and contribute to high rates of overweight and obesity among adolescents. Sedentary screen time can adversely affect food intake and food selection. Active video games may be a promising way of increasing daily physical activity levels among adolescents. Active video games may help modulate response inhibition and food intake. PURPOSE: Compare the effects of an acute bout of active and sedentary video gaming on N2 amplitudes (while viewing high calorie and low calorie images), Stroop Color Word Test (Stroop test) performance …
Assembly, Annotation And Optical Mapping Of The A Subgenome Of Avena, Rebekah Ann Lee
Assembly, Annotation And Optical Mapping Of The A Subgenome Of Avena, Rebekah Ann Lee
Theses and Dissertations
Common oat (Avena) has held a significant place within the global crop community for centuries; although its cultivation has decreased over the past century, its nutritional benefits have recently garnered increased interest for human consumption. No published reference sequences are available for any of the three oat subgenomes. Here we report a quality sequence assembly, annotation and hybrid optical map of the A-genome diploid Avena atlantica Baum and Fedak. The assembly is composed of a total of 3,417 contigs with an N50 of 11.86 Mb and an estimated completeness of 97.6%. This genome sequence will be a valuable research tool …
Capacity Of Human Immunodeficiency Virus Targeting Chimeric Antigen Receptor T Cells To Eliminate Follicular Dendritic Cells Bearing Human Immunodeficiency Virus Immune Complexes, Matthew T. Ollerton
Capacity Of Human Immunodeficiency Virus Targeting Chimeric Antigen Receptor T Cells To Eliminate Follicular Dendritic Cells Bearing Human Immunodeficiency Virus Immune Complexes, Matthew T. Ollerton
Theses and Dissertations
An important obstacle to a functional cure for HIV/AIDS is the persistence of viral reservoirs found throughout the body in various cells and tissues. Reservoirs can be latently infected cells, or in the case of follicular dendritic cells (FDC), non-infected cells that trap infectious virus on their surface through immune complexes (HIV-IC). Although several strategies have been employed to target and eliminate viral reservoirs, they are short-lived and ineffective. In an attempt to provide a long-term approach, chimeric antigen receptor T (CAR-T) cells were designed to eliminate native HIV on FDCs. Although effective at eliminating HIV-infected cells, and halting spreading …
Clinical Predictors Of Movement Patterns In Patients With Chronic Ankle Instability, Seong Jun Son
Clinical Predictors Of Movement Patterns In Patients With Chronic Ankle Instability, Seong Jun Son
Theses and Dissertations
BACKGROUND: Chronic ankle instability (CAI) patients have varying levels of mechanical and sensorimotor impairments that may lead to disparate functional movement patterns. Current literature on landing biomechanics in a CAI population, however, considers all patients as a homogeneous group. In our prior work, we identified 6 subgroups of movement patterns using lower extremity kinematics during a landing/cutting task and that showed promise in furthering understanding of movement patterns in a laboratory-based environment. To increase the utility of this methodology in clinical settings, there is a need to find easily administered clinical tests that can help identify multiple subgroups of movement …
Assembly, Annotation And Optical Mapping Of The A Subgenome Of Avena, Rebekah Ann Lee
Assembly, Annotation And Optical Mapping Of The A Subgenome Of Avena, Rebekah Ann Lee
Theses and Dissertations
Common oat (Avena) has held a significant place within the global crop community for centuries; although its cultivation has decreased over the past century, its nutritional benefits have recently garnered increased interest for human consumption. No published reference sequences are available for any of the three oat subgenomes. Here we report a quality sequence assembly, annotation and hybrid optical map of the A-genome diploid Avena atlantica Baum and Fedak. The assembly is composed of a total of 3,417 contigs with an N50 of 11.86 Mb and an estimated completeness of 97.6%. This genome sequence will be a valuable research tool …
Understanding Community And Ecophysiology Of Plant Species On The Colorado Plateau, Hannah Elizabeth Yokum
Understanding Community And Ecophysiology Of Plant Species On The Colorado Plateau, Hannah Elizabeth Yokum
Theses and Dissertations
The intensification of aridity due to anthropogenic climate change is likely to have a large impact on the growth and survival of plant species in the southwestern U.S. where species are already vulnerable to high temperatures and limited precipitation. Global climate change impacts plants through a rising temperature effect, CO2 effect, and land management. In order to forecast the impacts of global climate change, it is necessary to know the current conditions and create a baseline for future comparisons and to understand the factors and players that will affect what happens in the future. The objective of Chapter 1 is …
Ground Reaction Forces For Irish Dance Landings In Hard And Soft Shoes, Sarah Elizabeth Klopp
Ground Reaction Forces For Irish Dance Landings In Hard And Soft Shoes, Sarah Elizabeth Klopp
Theses and Dissertations
Introduction: Irish dance has evolved to become more athletically demanding, thus making the art form very hard on dancers' bodies. Irish dancers must land from difficult moves without letting their knees bend or heels touch the ground, causing large amounts of force to be absorbed by the body. Past studies have found dancers landing with a range of 4.5–6 times body weight, potentially causing high amounts of overuse injury. The majority of injuries incurred by Irish dancers are due to overuse (79.6%). The landings that occur in Irish dance have been minimally evaluated in current literature. Obtaining values of vertical …
Does Any Good Come From A Coach That Yells? Reflective Experiences From Former Athletes, David C. Barney, Alema Tauiliili
Does Any Good Come From A Coach That Yells? Reflective Experiences From Former Athletes, David C. Barney, Alema Tauiliili
Faculty Publications
Yelling in society is a common occurrence. Parents yell at their children, bosses yell at their employees and coaches yell at their athletes. Yet, in many cases the yelling coach exhibits unkind, loud in nature, and very personal statements. The purpose of this study was to better understand former athlete’s perspectives regarding their thoughts and experiences of their coaches yelling at them. For this study yelling will imply saying loud, unkind, personal comments towards the athlete. For this study 124 former athletes were surveyed regarding their experiences with a yelling coach. Generally, it was found that the former athletes did …
Impacts Of A Mixed Ungulate Community On Aspen Forests: From Landscape To Leaf, Aaron C. Rhodes
Impacts Of A Mixed Ungulate Community On Aspen Forests: From Landscape To Leaf, Aaron C. Rhodes
Theses and Dissertations
This dissertation explores the differential effects of an ungulate community (cattle, mule deer, and American elk) on aspen (Populus tremuloides) regeneration pre- and post-fire disturbance. It's first chapter examines the differential effects of cattle, mule deer, and American elk on aspen regeneration across variable topography, climate and forest type; aspen dominant to conifer dominant subalpine forests. We found that each ungulate species, if sufficiently numerous, can cause aspen regeneration failure. Also, high elevation, southern aspect and high winter snow pack increase resilience to ungulate herbivory. Chapter two compares the efficacy of four methods of estimating ungulate impact on …
Pharmaceutical And Natural (Exercise) Mechanisms To Mitigate The Negative Impact Of Ptsd And Chronic Stress On Synaptic Plasticity And Memory, Roxanne M. Miller
Pharmaceutical And Natural (Exercise) Mechanisms To Mitigate The Negative Impact Of Ptsd And Chronic Stress On Synaptic Plasticity And Memory, Roxanne M. Miller
Theses and Dissertations
Synapses can be altered due to experiences in a process called synaptic plasticity, which causes memory formations. Synapses can be strengthened through methods known as long-term potentiation (LTP) or weakened through long-term depression (LTD). Stresses can cause changes by altering synapses through either LTP or LTD. Rats were used to study the effects of post-traumatic stress disorder (PTSD)-like symptoms and a prophylactic treatment using pharmaceuticals. The first model used was the single prolonged stress (SPS) with two weeks of chronic light, which was not as effective for causing changes in synaptic plasticity. The second model, seven days of social defeat …
Pharmaceutical And Natural (Exercise) Mechanisms To Mitigate The Negative Impact Of Ptsd And Chronic Stress On Synaptic Plasticity And Memory, Roxanne M. Miller
Pharmaceutical And Natural (Exercise) Mechanisms To Mitigate The Negative Impact Of Ptsd And Chronic Stress On Synaptic Plasticity And Memory, Roxanne M. Miller
Theses and Dissertations
Synapses can be altered due to experiences in a process called synaptic plasticity, which causes memory formations. Synapses can be strengthened through methods known as long-term potentiation (LTP) or weakened through long-term depression (LTD). Stresses can cause changes by altering synapses through either LTP or LTD. Rats were used to study the effects of post-traumatic stress disorder (PTSD)-like symptoms and a prophylactic treatment using pharmaceuticals. The first model used was the single prolonged stress (SPS) with two weeks of chronic light, which was not as effective for causing changes in synaptic plasticity. The second model, seven days of social defeat …
Optimizing Monitoring Efforts Of Kit Fox (Vulpes Macrotis) In Utah, Kelsey Alina Richards
Optimizing Monitoring Efforts Of Kit Fox (Vulpes Macrotis) In Utah, Kelsey Alina Richards
Theses and Dissertations
The kit fox (Vulpes macrotis) is a species of conservation concern in western North America. Recent methods for monitoring populations of kit fox include using lures and remote cameras in an occupancy-modeling framework and habitat modeling to predict areas of occupancy. In chapter one, we tested the optimal lure and movement procedure for scent stations to maximize visits and detection of foxes, thereby improving estimates of occupancy. Between May 2015 and October 2016, we placed remote cameras at 522 random locations throughout nine study areas in the Colorado Plateau, Great Basin Desert, and Mojave Desert. Each location was …
Why Does It Take Two To Tango? Lifetime Fitness Consequences Of Parental Care In A Burying Beetle, Ashlee N. Smith, J. Curtis Creighton, Mark C. Belk
Why Does It Take Two To Tango? Lifetime Fitness Consequences Of Parental Care In A Burying Beetle, Ashlee N. Smith, J. Curtis Creighton, Mark C. Belk
Faculty Publications
In species that require parental care, each parent can either care for their offspring or leave them in the care of the other parent. For each parent this creates three possible parental care strategies: biparental care, uniparental (male or female) care, and uniparental desertion by either the male or female. The burying beetle, Nicrophorus orbicollis, typically exhibits biparental care of offspring, and thus provides a unique system that allows us to compare the fitness benefits of these parental care strategies in an unconfounded way. In this study, we assess the lifetime fitness of biparental care, uniparental care, and uniparental …
The Effects Of Physical Activity, Sedentary Time, And Atherosclerosison Fluid Flow In The Lumbar Intervertebral Disc, Jennifer Ann Bowden
The Effects Of Physical Activity, Sedentary Time, And Atherosclerosison Fluid Flow In The Lumbar Intervertebral Disc, Jennifer Ann Bowden
Theses and Dissertations
Physical activity impacts health and disease in multiple body tissues including the intervertebral discs. Fluid flow within the disc is an indicator of disc health that can be observed using diffusion weighted magnetic resonance imaging. We monitored activity levels of 26 participants, age 35 to 55 yrs, using Actigraph accelerometers for four days to evaluate vigorous-intensity activity, moderate to vigorous-intensity activity, and sedentary time. Participants underwent structural and diffusion weighted magnetic resonance imaging to evaluate intervertebral disc health and fluid flow. They also underwent bone density scans, carotid artery ultrasounds, a treadmill test, and a physical exam for pain, range …
Physiological Effects Of Pathogen And Herbivore Risks Encountered By Quaking Aspen, Anson Clark Call
Physiological Effects Of Pathogen And Herbivore Risks Encountered By Quaking Aspen, Anson Clark Call
Theses and Dissertations
Quaking aspen (Populus tremuloides) is the most widely distributed tree in North America (Lindroth and St Clair 2013), and a keystone species in our western montane forests (Worrall et al. 2015). Aspen has become a model organism for studies of genetics and physiology in woody plants (Bradshaw et al. 2000, Taylor 2002). Aspen is also economicallyimportant (Worrall et al. 2015) – wood is harvested for various uses, its scenic beauty helps sustain the tourism economy in many areas, and it has recently been studied as a possible source of biofuel (Sannigrahi et al. 2010). Aspen is also a …
Space Use, Resource Selection, And Survival Of Reintroduced Bighorn Sheep, Rusty Wade Robinson
Space Use, Resource Selection, And Survival Of Reintroduced Bighorn Sheep, Rusty Wade Robinson
Theses and Dissertations
Successful management of bighorn sheep depends on understanding the mechanisms responsible for population growth or decline, habitat selection, and utilization distribution after translocations. We studied a declining population of desert bighorn sheep in the North San Rafael Swell, Utah to determine birthdates of neonates, demographics, limiting factors, population size, probable cause of death, production, and survival. We documented 19 mortalities attributed to a variety of causes including cougar predation (n = 10, 53%), bluetongue virus (n = 2, 11%), reproductive complications (n = 2, 11%), hunter harvest (n = 1, 5%), and unknown (n = 4, 21%). Annual survival of …
Ground Reaction Forces Through A Range Of Speeds In Steeplechase Hurdling, James Brian Tracy
Ground Reaction Forces Through A Range Of Speeds In Steeplechase Hurdling, James Brian Tracy
Theses and Dissertations
The men's steeplechase event requires participants to jump over thirty-five 0.914-meter-tall obstacles, 4 rigid barriers and 1 fixed barrier followed by a 3.66-meter-long water pit per lap, over a 3000-meter distance. This study investigated the effect of increasing running velocity, through a range of 5.33 m/s to 6.66 m/s, on takeoff and landing ground reaction forces, for males during steeplechase hurdling using a force plate embedded under a track surface. Subjects completed 1 trial within each of 6 different pace ranges in a random order, once with a hurdle following the force plate to measure the takeoff ground reaction forces …
Teacher Perceptions Of School Breakfast Programs In Utah, Emily Breanne Krueger
Teacher Perceptions Of School Breakfast Programs In Utah, Emily Breanne Krueger
Theses and Dissertations
The objective of this study was to identify differences in teacher perceptions of benefits, challenges, and preferences to different School Breakfast Program (SBP) service models. A survey instrument was developed, pilot tested, and then distributed electronically to K-12 teachers throughout the state of Utah, who were part of the Utah Education Association. Demographics and factors influencing SBP models in Utah were gathered. Frequencies and ANOVA tests were performed and a significance level of <0.01 was chosen to protect for multiple comparisons. Results indicated that traditional breakfast was the most preferred model with a mean score of 2.80 and breakfast in the classroom was the least preferred model by teachers with a mean of -1.32. Children not going hungry was identified as the greatest benefit (95.4%, n=352) to SBP and food waste was identified as the greatest challenge (45.8%, n=168). This study concluded that increased awareness and education amongst teachers regarding different models of SBP service could lead to increased efficiency, increased participation in SBP, decreased costs, decreased food waste, and increased academic performance and health benefits for students.
Relationship Between Pectoralis Minor Length, Subacromial Space, And Pain In Swimmers And Overhead Athletes, Erika Jaci Richards
Relationship Between Pectoralis Minor Length, Subacromial Space, And Pain In Swimmers And Overhead Athletes, Erika Jaci Richards
Theses and Dissertations
Introduction (Context): The purpose of this study was to measure and correlate pectoralis minor length (PML) and acromiohumeral distance (AHD) in male and female collegiate swimmers, overhead athletes, and a control group. Methods: Participants underwent assessment of pain related to impingement syndrome with special tests (painful arc, external rotation resistance, empty can, and Neer's impingement test), as well as range of motion, measurement of PML, and measurement of subacromial space via ultrasound. Design: Cross-sectional, correlational study. Setting: University modalities laboratory. Participants: 60 healthy subjects (20 swimmers, 20 overhead athletes, 20 controls, age = 21.5 ± 2.4 years; height = 178.7 …
The Effect Of Cocoa Flavanols On Β-Cell Mass And Function, Thomas John Rowley
The Effect Of Cocoa Flavanols On Β-Cell Mass And Function, Thomas John Rowley
Theses and Dissertations
A hallmark of type 2 diabetes (T2D) is β-cell dysfunction and the eventual loss of functional β-cell mass. Therefore, mechanisms that improve or preserve β-cell function could be used to improve the quality of life of individuals with T2D. Studies have shown that monomeric, oligomeric and polymeric cocoa flavanols have different effects on obesity, insulin resistance and glucose tolerance. We hypothesized that these cocoa flavanols may have beneficial effects on β-cell function. INS-1 832/13 derived β-cells and primary rat islets cultured with a monomeric catechin-rich cocoa flavanol fraction demonstrated enhanced glucose-stimulated insulin secretion, while cells cultured with total cocoa extract, …
The Relationship Between Microbiota, Diet, And Energy Production In The Alpaca, Courtney Carroll
The Relationship Between Microbiota, Diet, And Energy Production In The Alpaca, Courtney Carroll
Theses and Dissertations
The alpaca is a small South American camelid (SAC) that is an important production animal in Peru, especially among the highly impoverished communities of the high Andes, and raised for its fiber and meat. Alpacas are highly reliant on the microbes within their digestive tracts to digest the plant material they consume; volatile fatty acids (VFAs) are released as a byproduct of this microbial fermentation and used as a major source of energy by the alpaca. To explore optimal parameters for alpaca microbiome analysis, performed 16S rRNA gene surveys on alpaca C1 and fecal samples that had been extracted using …