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Full-Text Articles in Life Sciences
Pvaast Anallysis Of Alzheimer’S Disease Sequencing Project Pedigree Data, Kristen Crofts, John S. K. Kauwe
Pvaast Anallysis Of Alzheimer’S Disease Sequencing Project Pedigree Data, Kristen Crofts, John S. K. Kauwe
Journal of Undergraduate Research
Alzheimer’s disease is a progressive brain disorder affecting more than 10 percent of Americans over the age of 65 (1). This disease destroys memory and thinking skills and is a leading cause of dementia. Although research in recent years has provided substantial information related to risk factors associated with Alzheimer’s disease, a great deal of information still remains unknown. PVAAST is a software tool that can analyze genome sequence data of Alzheimer’s patients in a creative way by also analyzing the patients’ pedigree information. With the combined information from family members, it is more feasible to identify genetic mutations related …
Mri T2 Signal Changes Indicate Tau Pathophysiology In A Murine Alzheimer's Disease Model, Rajan Deep Adhikari
Mri T2 Signal Changes Indicate Tau Pathophysiology In A Murine Alzheimer's Disease Model, Rajan Deep Adhikari
Theses and Dissertations
Pathogenesis, diagnosis and treatment, the essential domains in medical practice, seem helpless to address Alzheimer's disease (AD). With a huge mortality rate, it is looming and threatening the socioeconomic barrier. Despite many different studies, the pathogenesis of AD remains inconclusive. However, growing numbers of studies suggest oxidative stress to contribute to the initiation and progression of AD. We propose an iron hypothesis: iron mediated oxidative damage by reactive oxygen species (ROS), which induces protective roles of amyloid beta and hyper-phosphorylated tau (HP-tau) to sequester iron and limit the disease. We propose to study such mechanism using transgenic mice models for …
Alzheimer’S Risk Genes And Pathways Of Expression, Samantha Jensen, John Kauwe
Alzheimer’S Risk Genes And Pathways Of Expression, Samantha Jensen, John Kauwe
Journal of Undergraduate Research
Although Alzheimer’s disease (AD) has been the subject of research for nearly 100 years, these decades of research have not led to a unified understanding of the mechanisms behind the disease pathology1 ,2. Recent improvements in whole genome sequencing have made it possible for researchers to find a large number of mutations implicated in AD. Due to a high frequency of false positives and confounding factors, many mutations being investigated for therapies may not even have a causative effect on Alzheimer’s expression. Without concrete knowledge of the interactions of the proteins and genes implicated in the disease, drug development has …
Role Of Exercise And Stress In Memory And Learning Of The Hippocampus, Paul Baker, Jeff Edwards
Role Of Exercise And Stress In Memory And Learning Of The Hippocampus, Paul Baker, Jeff Edwards
Journal of Undergraduate Research
Some of the most devastating diseases today are diseases of the mind. Common side effects of Alzheimer’s disease are dementia and memory loss and more than 44 million people suffer from the disease worldwide [1]. Other mental diseases such as Parkinson’s also have a dramatic impact on the memory and learning pathways. Understanding the mechanism involved with memory and learning will bring science that much closer to finding a permanent cure to these devastating diseases.
Insulin And Ketones: Their Roles In Brain Mitochondrial Function, Sheryl Teresa Carr
Insulin And Ketones: Their Roles In Brain Mitochondrial Function, Sheryl Teresa Carr
Theses and Dissertations
The prevalence of both Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) is increasing worldwide, and the trends are unfortunately expected to continue. AD has recently been tied with mitochondrial dysfunction and insulin resistance, creating a mechanistic tie between AD and T2DM. Unfortunately, insulin resistance is often increased with aging and therefore, all individuals are at risk of brain mitochondrial dysfunction. Without proper mitochondrial function, the brain will degenerate, causing impaired cognitive function and reduced quality of life. The purpose of this study is two-fold: first, to understand the role of ceramides in insulin-induced brain mitochondrial dysfunction, and; second, …
Insulin And Ketones: Their Roles In Brain Mitochondrial Function, Sheryl Teresa Carr
Insulin And Ketones: Their Roles In Brain Mitochondrial Function, Sheryl Teresa Carr
Theses and Dissertations
The prevalence of both Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) is increasing worldwide, and the trends are unfortunately expected to continue. AD has recently been tied with mitochondrial dysfunction and insulin resistance, creating a mechanistic tie between AD and T2DM. Unfortunately, insulin resistance is often increased with aging and therefore, all individuals are at risk of brain mitochondrial dysfunction. Without proper mitochondrial function, the brain will degenerate, causing impaired cognitive function and reduced quality of life. The purpose of this study is two-fold: first, to understand the role of ceramides in insulin-induced brain mitochondrial dysfunction, and; second, …