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Articles 91 - 91 of 91
Full-Text Articles in Life Sciences
The Role Of Notch Signaling On Heart Rate And Atrial Conduction, Somya Bhatnagar
The Role Of Notch Signaling On Heart Rate And Atrial Conduction, Somya Bhatnagar
Undergraduate Research Symposium Posters
Heart disease is the leading cause of death worldwide and can result in arrhythmias, or dysregulation in the electrical activation of the heart. Sick Sinus Syndrome (SSS) is characterized by sinus bradycardia (slowed heart rate, HR), slowed conduction through atrial myocardium, and can predispose to the development of atrial fibrillation. A developmental signaling pathway, Notch, regulates cellular identity through differentiation of cardiomyocytes (CMs) into cardiac conduction system-like cells. Previous data show that Notch electrically remodels the right atrium, causing slowed conduction velocity (CV) and hallmarks of SSS including sinus pauses, sinus bradycardia and a predisposition to atrial fibrillation. However, the …