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The Effects Of Quercetin On Skeletal Muscle Mitochondrial Biogenesis And Oxphos Regulation, Jeff Lee Soileau
The Effects Of Quercetin On Skeletal Muscle Mitochondrial Biogenesis And Oxphos Regulation, Jeff Lee Soileau
LSU Master's Theses
A high fat diet causes a reduction in the expression of the genes of the electron transport chain, mitochondrial carrier proteins, and PGC-1α and PGC-1ß mRNA. Mitochondrial dysfunction has been linked to numerous chronic diseases. The antioxidant quercetin has been shown to protect against damage caused by exogenous and endogenous free radicals. The purpose of this study was to determine if quercetin would protect the genes of mitochondrial biogenesis (PGC-1α and PGC-1ß) and OXPHOS regulation (NDUFB5 and SDHB) from the downregulation caused by consumption of a high fat diet. The quadriceps muscle was removed from 21 male, C57BL/6J mice that …