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Full-Text Articles in Life Sciences
Combined Anthocyanins And Bromelain Supplement Improves Endothelial Function And Skeletal Muscle Oxygenation Status In Adults: A Double-Blind Placebo-Controlled Randomised Crossover Clinical Trial, Elizabeth J. Pekas, Jaehyun Shin, Ronald Headid Iii, Won-Mok Son, Gwenael Layec, Santosh K. Yadav, Steven D. Scott, Song-Young Park
Combined Anthocyanins And Bromelain Supplement Improves Endothelial Function And Skeletal Muscle Oxygenation Status In Adults: A Double-Blind Placebo-Controlled Randomised Crossover Clinical Trial, Elizabeth J. Pekas, Jaehyun Shin, Ronald Headid Iii, Won-Mok Son, Gwenael Layec, Santosh K. Yadav, Steven D. Scott, Song-Young Park
Health and Kinesiology Faculty Publications
Anthocyanins and bromelain have gained significant attention due to their antioxidative and anti-inflammatory properties. Both have been shown to improve endothelial function, blood pressure (BP) and oxygen utility capacity in humans; however, the combination of these two and the impacts on endothelial function, BP, total antioxidant capacity (TAC) and oxygen utility capacity have not been previously investigated. The purpose of this study was to investigate the impacts of a combined anthocyanins and bromelain supplement (BE) on endothelial function, BP, TAC, oxygen utility capacity and fatigability in healthy adults. Healthy adults (n 18, age 24 (SD 4) years) received BE or …
Increased Sod2 In The Diaphragm Contributes To Exercise-Induced Protection Against Ventilator-Induced Diaphragm Dysfunction, Stephanie E. Hall
Increased Sod2 In The Diaphragm Contributes To Exercise-Induced Protection Against Ventilator-Induced Diaphragm Dysfunction, Stephanie E. Hall
Kinesiology Faculty Publications and Presentations
Mechanical ventilation (MV) is a life-saving intervention for many critically ill patients. Unfortunately, prolonged MV results in rapid diaphragmatic atrophy and contractile dysfunction, collectively termed ventilator-induced diaphragm dysfunction (VIDD). Recent evidence reveals that endurance exercise training, performed prior to MV, protects the diaphragm against VIDD. While the mechanism(s) responsible for this exercise-induced protection against VIDD remain unknown, increased diaphragm antioxidant expression may be required. To investigate the role that increased antioxidants play in this protection, we tested the hypothesis that elevated levels of the mitochondrial antioxidant enzyme superoxide dismutase 2 (SOD2) is required to achieve exercise-induced protection against VIDD. Cause …
Increased Sod2 In The Diaphragm Contributes To Exercise-Induced Protection Against Ventilator-Induced Diaphragm Dysfunction, Aaron B. Morton, Ashley J. Smuder, Michael P. Wiggs, Stephanie E. Hall, Bumsoo Ahn, J. Matthew Hinkley, Noriko Ichinoseki-Sekine, Andres Mor Huertas, Mustafa Ozdemir, Toshinori Yoshihara, Nicholas R. Wawrzyniak, Scott K. Powers
Increased Sod2 In The Diaphragm Contributes To Exercise-Induced Protection Against Ventilator-Induced Diaphragm Dysfunction, Aaron B. Morton, Ashley J. Smuder, Michael P. Wiggs, Stephanie E. Hall, Bumsoo Ahn, J. Matthew Hinkley, Noriko Ichinoseki-Sekine, Andres Mor Huertas, Mustafa Ozdemir, Toshinori Yoshihara, Nicholas R. Wawrzyniak, Scott K. Powers
Health and Kinesiology Faculty Publications and Presentations
Mechanical ventilation (MV) is a life-saving intervention for many critically ill patients. Unfortunately, prolonged MV results in rapid diaphragmatic atrophy and contractile dysfunction, collectively termed ventilator-induced diaphragm dysfunction (VIDD). Recent evidence reveals that endurance exercise training, performed prior to MV, protects the diaphragm against VIDD. While the mechanism(s) responsible for this exercise-induced protection against VIDD remain unknown, increased diaphragm antioxidant expression may be required. To investigate the role that increased antioxidants play in this protection, we tested the hypothesis that elevated levels of the mitochondrial antioxidant enzyme superoxide dismutase 2 (SOD2) is required to achieve exercise-induced protection against VIDD. Cause …
Skeletal Muscle Function, Morphology, And Biochemistry In Ts65dn Mice: A Model Of Down Syndrome, Patrick Michael Cowley
Skeletal Muscle Function, Morphology, And Biochemistry In Ts65dn Mice: A Model Of Down Syndrome, Patrick Michael Cowley
Exercise Science - Dissertations
A common clinical observation of persons with Down syndrome at all developmental stages is hypotonia and generalized muscle weakness. The cause of muscle weakness in Down syndrome is not known and there is an immediate need to establish an acceptable animal model to explore the muscle dysfunction that is widely reported in the human population. Using a combination of functional, histological, and biochemical analyses this dissertation provides the initial characterization of skeletal muscle from the Ts65Dn mouse, a model of Down syndrome. The experiments revealed that Ts65Dn muscle over-expresses SOD1 protein but this did not lead to oxidative stress. Ts65Dn …
Oxidative Stress Response To Short Duration Bout Of Submaximal Aerobic Exercise In Healthy Young Adults, Keith M. Diaz, Deborah L. Feairheller Phd, Kathleen M. Sturgeon, Sheara T. Williamson, Michael D. Brown
Oxidative Stress Response To Short Duration Bout Of Submaximal Aerobic Exercise In Healthy Young Adults, Keith M. Diaz, Deborah L. Feairheller Phd, Kathleen M. Sturgeon, Sheara T. Williamson, Michael D. Brown
International Journal of Exercise Science
The purpose of this study was to investigate the oxidative stress response to a short duration bout of submaximal exercise in a cohort of healthy young adults. 15 apparently healthy college age males and females completed a modified Bruce-protocol treadmill test to 75-80% of their heart rate reserve. Blood samples collected immediately before (pre-exercise), immediately after, 30, 60 and 120 minutes post-exercise were assayed for total antioxidant capacity (TAC), superoxide disumutase (SOD), thiobarbituric acid-reactive substances (TBARS), and protein carbonyls (PC). SOD activity was significantly increased from pre-exercise levels at 30 minutes (77%), 60 minutes (33%), and 120 minutes (37%) post-exercise. …
The Effects Of Quercetin On Skeletal Muscle Mitochondrial Biogenesis And Oxphos Regulation, Jeff Lee Soileau
The Effects Of Quercetin On Skeletal Muscle Mitochondrial Biogenesis And Oxphos Regulation, Jeff Lee Soileau
LSU Master's Theses
A high fat diet causes a reduction in the expression of the genes of the electron transport chain, mitochondrial carrier proteins, and PGC-1α and PGC-1ß mRNA. Mitochondrial dysfunction has been linked to numerous chronic diseases. The antioxidant quercetin has been shown to protect against damage caused by exogenous and endogenous free radicals. The purpose of this study was to determine if quercetin would protect the genes of mitochondrial biogenesis (PGC-1α and PGC-1ß) and OXPHOS regulation (NDUFB5 and SDHB) from the downregulation caused by consumption of a high fat diet. The quadriceps muscle was removed from 21 male, C57BL/6J mice that …