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Articles 1 - 30 of 1566
Full-Text Articles in Life Sciences
A Novel Algorithm For The Virtual Screening Of Extensive Small Molecule Libraries Against Ercc1/Xpf Protein-Protein Interaction For The Identification Of Therapeutic Resistance-Bypassing Small Anticancer Molecules, Salma Ghazy, Lalehan Oktay, Serdar Durdagi
A Novel Algorithm For The Virtual Screening Of Extensive Small Molecule Libraries Against Ercc1/Xpf Protein-Protein Interaction For The Identification Of Therapeutic Resistance-Bypassing Small Anticancer Molecules, Salma Ghazy, Lalehan Oktay, Serdar Durdagi
Turkish Journal of Biology
Background and aim:Cancer cell’s innate chemotherapeutic resistance continues to be an obstacle in molecular oncology. This theory is firmly tied to the cancer cells’ integral DNA repair mechanisms continuously neutralizing the effects of chemotherapy. Amidst these mechanisms, the nuclear excision repair pathway is crucial in renovating DNA lesions prompted by agents like Cisplatin. The ERCC1/XPF complex stands center-stage as a structure specific endonuclease in this repair pathway. Targeting the ERCC1/XPF dimerization brings forth a strategy to augment chemotherapy by eschewing the resistance mechanism integral to cancer cells. This study tracks and identifies small anticancer molecules, with ERCC1/XPF inhibiting potential, within …
Tip 2 Diyabet Ve Buna Bağlı Komplikasyonlarda Nampt, Il-6 Ve Vaspin Gen Ekspresyonları Ve Serum Protein Düzeyleri, Süheyla Pınar Çelik, Damla Nur Parıltı, Leyla Açık, Mehmet Muhittin Yalçın, İlhan Yetkin, Eldeniz Yunusov
Tip 2 Diyabet Ve Buna Bağlı Komplikasyonlarda Nampt, Il-6 Ve Vaspin Gen Ekspresyonları Ve Serum Protein Düzeyleri, Süheyla Pınar Çelik, Damla Nur Parıltı, Leyla Açık, Mehmet Muhittin Yalçın, İlhan Yetkin, Eldeniz Yunusov
Turkish Journal of Biology
Type 2 diabetes (T2DM) is the most common type of diabetes and occurs due to insufficient insulin secretion or inability to use existing insulin and the effects of environmental factors. Although there are many studies on the pathophysiology of T2DM, the mechanisms playing a role in the pathogenesis of insulin resistance and pancreatic beta-cell dysfunction have not been fully elucidated. Some adipokines secreted from adipose tissue, which are the primary regulators of insulin resistance, affect immune and inflammatory functions. Altered adipokine profiles have been observed in obesity and T2DM, leading to severe metabolic risks and changes in insulin sensitivity. This …
Circ-Mettl15 Stimulates The Aggressive Behaviors Of Papillary Thyroid Cancer Cells By Coordinating The Mir-200c-3p/Xiap Axis, Yuhao Huang, Xinyu Zeng, Yanling Cai, Yan Yang, Yujie Zhang, Yiqi Ma, Suping Li
Circ-Mettl15 Stimulates The Aggressive Behaviors Of Papillary Thyroid Cancer Cells By Coordinating The Mir-200c-3p/Xiap Axis, Yuhao Huang, Xinyu Zeng, Yanling Cai, Yan Yang, Yujie Zhang, Yiqi Ma, Suping Li
Turkish Journal of Biology
Background and objective: Thyroid cancer is the most common malignant tumor in the endocrine system. Papillary thyroid carcinoma (PTC) accounts for the vast majority of cases in this cancer. Recently, the vital role of circular RNA (circRNA) has been acknowledged in various cancers. However, to date, few studies have examined the roles of circRNAs in PTC. Therefore, this research aimed at exploring the function and mechanism of circ-methyltransferase-like 15 (METTL15) in PTC cells.Methods: First, quantitative measurements of circ-METTL15, miR-200c-3p, and X-linked inhibitor of apoptosis protein (XIAP) in PTC cells were completed with reverse transcription-quantitative polymerase chain reaction or Western blot …
Mir-770-5p-Induced Cellular Switch To Sensitize Trastuzumab Resistant Breast Cancer Cells Targeting Her2/Egfr/Igf1r Bidirectional Crosstalk, Senem Noyan, Bala Gür Dedeoğlu
Mir-770-5p-Induced Cellular Switch To Sensitize Trastuzumab Resistant Breast Cancer Cells Targeting Her2/Egfr/Igf1r Bidirectional Crosstalk, Senem Noyan, Bala Gür Dedeoğlu
Turkish Journal of Biology
Background/aim: Studies highlighted the bidirectional crosstalk between the HER family members in breast cancer as resistance mechanism to anti-HER agents. Cross-signaling between HER2/EGFR and ER/IGF1R could play role in the development of resistance to therapeutics hence stimulating cell growth. To overcome this resistance, combined therapies targeting both pathways simultaneously have been proposed as an effective strategy. The involvement of miRNAs in resistance of targeted therapies like trastuzumab was demonstrated in recent studies. Hence the regulation of miRNAs in resistance state could reverse the cell behaviour to drugs. Previously we found that overexpression of miR-770-5p downregulated AKT and ERK expression through …
Non-Small Cell Lung Cancer Treatment: Current Status Of Drug Repurposing And Nanoparticle-Based Drug Delivery Systems, Tugba Gul Inci, Serap Acar, Di̇lek Balik
Non-Small Cell Lung Cancer Treatment: Current Status Of Drug Repurposing And Nanoparticle-Based Drug Delivery Systems, Tugba Gul Inci, Serap Acar, Di̇lek Balik
Turkish Journal of Biology
Drug repurposing is the strategy of drug utilization for a treatment option other than the intended indications and has increased over the past decades, especially within cancer nanomedicine. Cancer nanomedicine has been facilitated through nanoparticle-based (NP-based) delivery systems which can combat NSCLC via recent advances in nanotechnology and apply its benefits to existing drugs. An effective therapeutic solution could be gained via repurposing and accelerated via NP-based drug delivery systems. This review aims to present an overview of NSCLC treatments with a special focus on drug repurposing with details of clinical study advances and NP-based drug delivery systems for NSCLC. …
Beneficial Effects Of A Novel Polyherbal Formulation On The Skeletal Muscle Antioxidant Status, Inflammation, And Muscle-Signaling Proteins In Exercised Rats, Mehmet Tuzcu, Oğuzhan Özdemi̇r, Cemal Orhan, Nurhan Şahi̇n, Abhijeet Morde, Muralidhara Padigaru, Prakash Bhanuse, Kazım Şahi̇n
Beneficial Effects Of A Novel Polyherbal Formulation On The Skeletal Muscle Antioxidant Status, Inflammation, And Muscle-Signaling Proteins In Exercised Rats, Mehmet Tuzcu, Oğuzhan Özdemi̇r, Cemal Orhan, Nurhan Şahi̇n, Abhijeet Morde, Muralidhara Padigaru, Prakash Bhanuse, Kazım Şahi̇n
Turkish Journal of Biology
Beneficial effects of a novel polyherbal formulation on the skeletal muscle antioxidant status, inflammation, and muscle-signaling proteins in exercised rats
Theranostic Potential Of A Novel Aptamer Specifically Targeting Her2 In Breast Cancer Cells, Fulya Küçükcankurt, Samet Uçak, Nedret Altiok
Theranostic Potential Of A Novel Aptamer Specifically Targeting Her2 In Breast Cancer Cells, Fulya Küçükcankurt, Samet Uçak, Nedret Altiok
Turkish Journal of Biology
Theranostic potential of a novel aptamer specifically targeting HER2 in breast cancer cells
Tnfr1 Signaling Is Positively Regulated By Jak-2 And C-Src Via Tyrosine Phosphorylation, Fatma Zehra Hapi̇l Zevkli̇ler, Fatma Ece Çopuroğlu, Mustafa Gökhan Ertosun, Ufuk Mert, Derya Özeş, Osman Nidai Özeş
Tnfr1 Signaling Is Positively Regulated By Jak-2 And C-Src Via Tyrosine Phosphorylation, Fatma Zehra Hapi̇l Zevkli̇ler, Fatma Ece Çopuroğlu, Mustafa Gökhan Ertosun, Ufuk Mert, Derya Özeş, Osman Nidai Özeş
Turkish Journal of Biology
TNFR1 signaling is positively regulated by Jak-2 and c-Src via tyrosine phosphorylation
Prognostic Gene Biomarkers For C-Src Inhibitor Si162 Sensitivity In Melanoma Cells, Seyhan Türk, Ayşegül Yilmaz, Ümit Yavuz Malkan, Gülberk Uçar, Can Türk
Prognostic Gene Biomarkers For C-Src Inhibitor Si162 Sensitivity In Melanoma Cells, Seyhan Türk, Ayşegül Yilmaz, Ümit Yavuz Malkan, Gülberk Uçar, Can Türk
Turkish Journal of Biology
Prognostic gene biomarkers for c-Src inhibitor Si162 sensitivity in melanoma cells
Expression Patterns Of M6a Rna Methylation Regulators Under Apoptotic Conditions In Various Human Cancer Cell Lines, Azime Akçaöz Alasar, Buket Sağlam, İpek Erdoğan Vatansever, Bünyamin Akgül
Expression Patterns Of M6a Rna Methylation Regulators Under Apoptotic Conditions In Various Human Cancer Cell Lines, Azime Akçaöz Alasar, Buket Sağlam, İpek Erdoğan Vatansever, Bünyamin Akgül
Turkish Journal of Biology
Expression patterns of m6A RNA methylation regulators under apoptotic conditions in various human cancer cell lines
Circrna Ldlr Promotes Proliferation And Aerobic Glycolysis Of Gastric Cancer Cells By Targeting Chd1 With Mir-449b-5p, Fanye Zeng, Juntao Zhao, Mengting Tong, Wenting He, Nan Li, Yuxiang Fan, Yanhua Zhu, Liping Zhang, Hongliang Zhang
Circrna Ldlr Promotes Proliferation And Aerobic Glycolysis Of Gastric Cancer Cells By Targeting Chd1 With Mir-449b-5p, Fanye Zeng, Juntao Zhao, Mengting Tong, Wenting He, Nan Li, Yuxiang Fan, Yanhua Zhu, Liping Zhang, Hongliang Zhang
Turkish Journal of Biology
CircRNA LDLR promotes proliferation and aerobic glycolysis of gastric cancer cells by targeting CHD1 with miR-449b-5p
Effect Of Thymol On Oxidative Stress And Reelin Signaling Pathway In Alzheimer's Disease Model, Barış Bi̇tmez, Burcu Çevreli̇, Emel Kaşikçi
Effect Of Thymol On Oxidative Stress And Reelin Signaling Pathway In Alzheimer's Disease Model, Barış Bi̇tmez, Burcu Çevreli̇, Emel Kaşikçi
Turkish Journal of Biology
Effect of thymol on oxidative stress and reelin signaling pathway in Alzheimer's disease model
Divergent Proteomic Profiles Of Opium Poppy Cultivars, Setenay Aykanat, Mine Türktaş
Divergent Proteomic Profiles Of Opium Poppy Cultivars, Setenay Aykanat, Mine Türktaş
Turkish Journal of Biology
Divergent Proteomic Profiles of Opium Poppy Cultivars
Svm-Do: Identification Of Tumor-Discriminating Mrna Signatures Via Support Vectormachines Supported By Disease Ontology, Mustafa Erhan Özer, Pemra Özbek Sarica, Kazim Yalçin Arğa
Svm-Do: Identification Of Tumor-Discriminating Mrna Signatures Via Support Vectormachines Supported By Disease Ontology, Mustafa Erhan Özer, Pemra Özbek Sarica, Kazim Yalçin Arğa
Turkish Journal of Biology
Background/aim: The complicated nature of tumor formation makes it difficult to identify discriminatory genes. Recently, transcriptome-based supervised classification methods using support vector machines (SVMs) have become popular in this field. However, the inclusion of less significant variables in the construction of classification models can lead to misclassification. To improve model performance, feature selection methods such as enrichment analysis can be used to extract useful variable sets. The detection of genes that can discriminate between normal and tumor samples in the association of cancer and disease remains an area of limited information. We therefore aimed to discover novel and practical sets …
Deep Learning In Bioinformatics, Malik Yousef, Jens Allmer
Deep Learning In Bioinformatics, Malik Yousef, Jens Allmer
Turkish Journal of Biology
Deep learning is a powerful machine learning technique that can learn from large amounts of data using multiple layers of artificial neural networks. This paper reviews some applications of deep learning in bioinformatics, a field that deals with analyzing and interpreting biological data. We first introduce the basic concepts of deep learning and then survey the recent advances and challenges of applying deep learning to various bioinformatics problems, such as genome sequencing, gene expression analysis, protein structure prediction, drug discovery, and disease diagnosis. We also discuss future directions and opportunities for deep learning in bioinformatics. We aim to provide an …
Stemnesscore: An R Package To Estimate The Stemness Of Glioma Cancer Cells At Single-Cell Resolution, Necla Koçhan, Yavuz Oktay, Gökhan Karakülah
Stemnesscore: An R Package To Estimate The Stemness Of Glioma Cancer Cells At Single-Cell Resolution, Necla Koçhan, Yavuz Oktay, Gökhan Karakülah
Turkish Journal of Biology
Background/aim: Glioblastoma is the most heterogeneous and the most difficult-to-treat type of brain tumor and one of the deadliest among all cancers. The high plasticity of glioma cancer stem cells and the resistance they develop against multiple modalities of therapy, along with their high heterogeneity, are the main challenges faced during treatment of glioblastoma. Therefore, a better understanding of the stemness characteristics of glioblastoma cells is needed. With the development of various single-cell technologies and increasing applications of machine learning, indices based on transcriptomic and/or epigenomic data have been developed to quantitatively measure cellular states and stemness. In this study, …
Classification Of Colon Cancer Patients Into Consensus Molecular Subtypes Using Support Vector Machines, Necla Koçhan, Baris Emre Dayanc
Classification Of Colon Cancer Patients Into Consensus Molecular Subtypes Using Support Vector Machines, Necla Koçhan, Baris Emre Dayanc
Turkish Journal of Biology
Background/aim: The molecular heterogeneity of colon cancer has made classification of tumors a requirement for effective treatment. One of the approaches for molecular subtyping of colon cancer patients is the Consensus Molecular Subtypes (CMS) developed by the Colorectal Cancer Subtyping Consortium (CRCSC). CMS-specific RNA-Seq dependent classification approaches are recent with relatively low sensitivity and specificity. In this study, we aimed to classify patients into CMS groups using RNA-seq profiles. Materials and methods: We first identified subtype specific and survival associated genes using Fuzzy C-Means (FCM) algorithm and log-rank test. Then we classified patients using Support Vector Machines with Backward Elimination …
Physicochemical Differences Between Camelid Single-Domain Antibodies And Mammalian Antibodies, Nazli Eda Eski̇er, Doğa Eski̇er, Esi̇n Fi̇ruzan, Si̇bel Kalyoncu
Physicochemical Differences Between Camelid Single-Domain Antibodies And Mammalian Antibodies, Nazli Eda Eski̇er, Doğa Eski̇er, Esi̇n Fi̇ruzan, Si̇bel Kalyoncu
Turkish Journal of Biology
Background/aim: In recent years, single-domain antibodies, also known as nanobodies, have emerged as an alternative to full immunoglobulin Gs (IgGs), due to their various advantages including increased solubility, faster clearance, and cheaper production. Nanobodies are generally derived from the variable domain of the camelid heavy-chain-only immunoglobulin Gs (hcIgGs). Due to the high sequence homology between variable heavy chains of camelids (VHHs) and humans (VHs), hcIgGs are ideal candidates for nanobody development. However, further examination is needed to understand the structural differences between VHs and VHHs. This analysis is essential for nanobody engineering to mitigate potential immunogenicity while preserving stability, functionality, …
Suma: A Lightweight Machine Learning Model Powered Shared Nearest Neighbour Based Clustering Application Interface Of Scrna-Seq, Hamza Umut Karakurt, Pınar Pir
Suma: A Lightweight Machine Learning Model Powered Shared Nearest Neighbour Based Clustering Application Interface Of Scrna-Seq, Hamza Umut Karakurt, Pınar Pir
Turkish Journal of Biology
Background/aim: Single-cell transcriptomics (scRNA-Seq) explores cellular diversity at the gene expression level. Due to the inherent sparsity and noise in scRNA-Seq data and the uncertainty on the types of sequenced cells, effective clustering and cell type annotation are essential. The graph-based clustering of scRNA-Seq data is a simple yet powerful approach which presents data as a “shared nearest neighbour” graph and clusters the cells using graph clustering algorithms. These algorithms are dependent on several user-defined parameters. Here we present SUMA, a lightweight tool that uses a random forest model to predict the optimum number of neighbours to have the optimum …
Compcorona: A Web Application For Comparative Transcriptome Analyses Ofcoronaviruses Reveals Sars-Cov-2-Specific Host Response, Rana Sali̇hoğlu, Fati̇h Saraçoğlu, Mustafa Si̇bai̇, Tali̇p Zengi̇n, Başak Abak Masud, Onur Karasoy, Tuğba Önal Süzek
Compcorona: A Web Application For Comparative Transcriptome Analyses Ofcoronaviruses Reveals Sars-Cov-2-Specific Host Response, Rana Sali̇hoğlu, Fati̇h Saraçoğlu, Mustafa Si̇bai̇, Tali̇p Zengi̇n, Başak Abak Masud, Onur Karasoy, Tuğba Önal Süzek
Turkish Journal of Biology
Background/aim: Understanding the mechanism of host transcriptomic response to infection by the SARS-CoV-2 virus is crucial, especially for patients suffering from long-term effects of COVID-19, such as long COVID or pericarditis inflammation, potentially linked to side effects of the SARS-CoV-2 spike proteins. We conducted comprehensive transcriptome and enrichment analyses on lung and peripheral blood mononuclear cells (PBMCs) infected with SARS-CoV-2, as well as on SARS-CoV and MERS-CoV, to uncover shared pathways and elucidate their common disease progression and viral replication mechanisms. Materials and methods: We developed CompCorona, the first interactive online tool for visualizing gene response variance among the family …
Mitochondrial Transplantation And Transfer: The Promising Method For Diseases, Gökhan Burçi̇n Kubat
Mitochondrial Transplantation And Transfer: The Promising Method For Diseases, Gökhan Burçi̇n Kubat
Turkish Journal of Biology
Mitochondria are organelles that serve as the powerhouses for cellular bioenergetics in eukaryotic cells. It is responsible for mitochondrial adenosine triphosphate (ATP) generation, cell signaling and activity, calcium balance, cell survival, proliferation, apoptosis, and autophagy. Mitochondrial transplantation is a promising disease therapy that involves the recovery of mitochondrial dysfunction using isolated functioning mitochondria. The objective of the present article is to provide current knowledge on natural mitochondrial transfer processes, in vitro and in vivo applications of mitochondrial transplantation, clinical trials, and challenges associated with mitochondrial transplantation.
Ribosomal Protein L8 Regulates The Expression And Splicing Pattern Of Genes Associated With Cancer-Related Pathways, Leilei Xu, Gui Yang, Bin Song, Dong Chen, Akbar. Yunus, Jiangtao Chen, Xiaogang Yang, Zheng Tian
Ribosomal Protein L8 Regulates The Expression And Splicing Pattern Of Genes Associated With Cancer-Related Pathways, Leilei Xu, Gui Yang, Bin Song, Dong Chen, Akbar. Yunus, Jiangtao Chen, Xiaogang Yang, Zheng Tian
Turkish Journal of Biology
Background/aim: Ribosomal proteins have been shown to perform unique extraribosomal functions in cell apoptosis and other biological processes. Ribosomal protein L8 (RPL8) not only has important nonribosomal regulatory functions but also participates in the oncogenesis and development of tumors. However, the specific biological functions and pathways involved in this process are still unknown. Materials and methods: RPL8 was overexpressed (RPL8-OE) in HeLa cells. MTT assay and flow cytometry were used to detect cell proliferation and apoptosis, respectively. Transcriptome sequencing was performed to analyze the differentially expressed genes (DEGs) and regulated alternative splicing events (RASEs) by RPL8-OE, both of which were …
Gooseberry Anthocyanins Alleviate Insulin Resistance By Regulating Ceramide Metabolism In High Fat Diet Mice, Xian Tang, Jun Gao, Jinpeng Huang, Chenjuan Zhang, Hongwei Liu, Jie Wei
Gooseberry Anthocyanins Alleviate Insulin Resistance By Regulating Ceramide Metabolism In High Fat Diet Mice, Xian Tang, Jun Gao, Jinpeng Huang, Chenjuan Zhang, Hongwei Liu, Jie Wei
Turkish Journal of Biology
Background/aim: Obesity is the fifth largest risk factor of death in the world. The ceramide produced by obesity is closely related to insulin resistance (IR) caused by obesity. At present, the commercially available weight loss products have large side effects and limited therapeutic effects. Therefore, it is particularly important to find effective natural nontoxic products to treat obesity and explore its possible pathways and mechanisms. Materials and methods: In this paper, a high-fat diet (HFD) mice model was established by intragastric administration of high-fat emulsion to investigate the intervention effect of Gooseberry anthocyanins (GA) on IR in HFD mice. We …
Androgen Receptor Contributes To Repairing Dna Damage Induced By Inflammation And Oxidative Stress In Prostate Cancer, Bi̇lge Debeleç Bütüner, Nurşah Ertunç Hasbal, Eli̇f İşel, Dirk Roggenbuck, Kemal Sami̇ Korkmaz
Androgen Receptor Contributes To Repairing Dna Damage Induced By Inflammation And Oxidative Stress In Prostate Cancer, Bi̇lge Debeleç Bütüner, Nurşah Ertunç Hasbal, Eli̇f İşel, Dirk Roggenbuck, Kemal Sami̇ Korkmaz
Turkish Journal of Biology
Background: Androgen deprivation therapy remains the first-line therapy option for prostate cancer, mostly resulting in the transition of the disease to a castration-resistant state. The lack of androgen signaling during therapy affects various cellular processes, which sometimes paradoxically contributes to cancer progression. As androgen receptor (AR) signaling is known to contribute to oxidative stress regulation, loss of AR may also affect DNA damage level and the response mechanism in oxidant and inflammatory conditions of the prostate tumor microenvironment. Therefore, this study aimed to investigate the role of AR and AR-regulated tumor suppressor NKX3.1 upon oxidative stress-induced DNA damage response (DDR) …
Antioxidant Potential Of Nanomaterials, David Gonzalez Flores, Javier Espino, Jose A. Pariente
Antioxidant Potential Of Nanomaterials, David Gonzalez Flores, Javier Espino, Jose A. Pariente
Turkish Journal of Biology
Background/aim: The novel field of nanomaterials allows infinite possibilities in order to create antioxidant therapies. The present review is aimed to describe the state of art concerning on nanomaterials and their effects on reactive oxygen species (ROS) production. A wide range of nanoparticles has been designed for this purpose, and each one possesses some particular characteristics which allow these significant antioxidant results. Several in vivo and in vitro works state the ability of these nanoparticles to mimic the redox systems of the cells, and thus, the potential role of nanoparticles as antioxidant treatment for several diseases. Materials and methods: This …
A Review With Updated Perspectives On In Vitro And In Vivo Wound Healing Models, Murni Nazira Sarian, Nabilah Zulkefli, Shazeli Zain, Sandra Maniam, Sharida Fakurazi
A Review With Updated Perspectives On In Vitro And In Vivo Wound Healing Models, Murni Nazira Sarian, Nabilah Zulkefli, Shazeli Zain, Sandra Maniam, Sharida Fakurazi
Turkish Journal of Biology
A skin wound or perforation triggers a series of homeostatic reactions to safeguard internal organs from invasion by pathogens or other substances that could damage body tissues. An injury may occasionally heal quickly, leading to the closure of the skin's structure. Healing from chronic wounds takes a long time. Although many treatment options are available to manage wound healing, an unmet therapy need remains because of the complexity of the processes and the other factors involved. It is crucial to conduct consistent research on novel therapeutic approaches to find an effective healing agent. Therefore, this work aims to cover various …
Soloxolone Methyl Induces Apoptosis And Oxidative/Er Stress In Breast Cancer Cells And Target Cancer Stem Cell Population, Eli̇f Ertürk, Oğuzhan Akgün, Yaren Yildiz, Pinar Kalkan, Oksana V. Salomatina, Nariman F. Salakhutdinov, Engi̇n Ulukaya, Ferda Ari
Soloxolone Methyl Induces Apoptosis And Oxidative/Er Stress In Breast Cancer Cells And Target Cancer Stem Cell Population, Eli̇f Ertürk, Oğuzhan Akgün, Yaren Yildiz, Pinar Kalkan, Oksana V. Salomatina, Nariman F. Salakhutdinov, Engi̇n Ulukaya, Ferda Ari
Turkish Journal of Biology
One of the most prevalent malignancies in women and one of the leading causes of cancer-related death is breast cancer. There is a need for new treatment approaches and drugs for breast cancer. Many studies show the high potential of triterpene compounds and their semisynthetic derivatives as anticancer agents due to their ability to induce apoptosis and suppress tumorigenesis. The effects of soloxolone methyl (SM), a semisynthetic derivative of 18-H-glycyrrhetinic acid, on the cytotoxicity and apoptosis of human breast cancer cell line (T-47D) and cancer stem cell (CSCs) population (mammospheres; CD44+/CD24-antigen) derived from breast cancer cells, were examined in this …
The Effects Of Anti-Pd-L1 Monoclonal Antibody On The Expression Of Angiogenesis And Invasion-Related Genes, Cansu Babahan, Samira Abdi Abgarmi, Fatma Gi̇zem Sonugür, Müge Öçal Demi̇rtaş, Hakan Akbulut
The Effects Of Anti-Pd-L1 Monoclonal Antibody On The Expression Of Angiogenesis And Invasion-Related Genes, Cansu Babahan, Samira Abdi Abgarmi, Fatma Gi̇zem Sonugür, Müge Öçal Demi̇rtaş, Hakan Akbulut
Turkish Journal of Biology
Background/aim: The role of PD-L1 in regulating the immunosuppressive tumor microenvironment via its binding on PD-1 receptors is extensively studied. The PD-1/PD-L1 axis is a significant way of cancer immune escape, and PD-L1 expression on tumor cells is suggested as a predictive marker for anti-PD-1/PD-L1 monoclonal antibodies (MoAbs). However, the tumor-intrinsic role of PDL1 is not known well. Therefore, we aimed to investigate the effects of anti-PD-L1 antibodies on the expression of angiogenesis and metastasis-related genes in tumor cells. Materials and methods: The experiments were done with prostate cancer and melanoma cells with low PD-L1 expression (<5%) and prostate and breast cancer cells with high PD-L1 expression (>50%). The gene …
Antileukemic Potential Of Nile Blue-Mediated Photodynamic Therapy On Hl60 Human Myeloid Leukemia Cells, Serçi̇n Özlem Çalişkan, Aynur Karadağ, Bariş Uzunok, Numan Taşpinar, Berna Akin, Meti̇n Çalişkan, Rahşan Ilikçi Sağkan
Antileukemic Potential Of Nile Blue-Mediated Photodynamic Therapy On Hl60 Human Myeloid Leukemia Cells, Serçi̇n Özlem Çalişkan, Aynur Karadağ, Bariş Uzunok, Numan Taşpinar, Berna Akin, Meti̇n Çalişkan, Rahşan Ilikçi Sağkan
Turkish Journal of Biology
Background/aim: Photodynamic therapy (PDT) has received great attention over the past decade in the treatment of diseases such as leukemia which is a cancer of the blood and bone marrow cells that causes a significant number of deaths worldwide. In this study, it was aimed to investigate the effects of Nile blue-mediated PDT (NB-mediated PDT) on HL60 cells. Materials and methods: The effect of NB-mediated PDT on cell proliferation was evaluated with cell volume analysis using flow cytometry at 24 h. Cell apoptosis, ROS production, mitochondrial membrane potential, and cell cycle analysis were evaluated using annexin V-FITC, H2 DCFDA, JC-1, …
Targeting Of Notch, Il-1, And Leptin Has Therapeutic Potential In Xenograft Colorectal Cancer, Rumeysa Özyurt, Ni̇lüfer Erkasap, Mete Özkurt, Serdar Mustafa Erkasap, Konstanti̇nos Di̇mas, Ayşe Çakir Gündoğdu, Engi̇n Ulukaya
Targeting Of Notch, Il-1, And Leptin Has Therapeutic Potential In Xenograft Colorectal Cancer, Rumeysa Özyurt, Ni̇lüfer Erkasap, Mete Özkurt, Serdar Mustafa Erkasap, Konstanti̇nos Di̇mas, Ayşe Çakir Gündoğdu, Engi̇n Ulukaya
Turkish Journal of Biology
Background/aim: Colorectal cancer (CRC) is a fatal malignancy type and its occurence still needs to be explored mechanistically. Notch, IL-1, and leptin crosstalk is reported to play a role in the proliferation, migration, and expression of proangiogenic molecules. In this study, we aimed to investigate the effect of inhibition of Notch, IL-1, and leptin on CRC. Materials and methods: To generate colorectal cancer tumor xenografts, 1 × 107 cells from exponentially growing cultures of HCT15 cells were injected subcutaneously, at the axillary region of the left and right rear flanks of forty NOD.CB17-Prkdcscid/J (NOD/SCID) female mice. The mice were then …