Operations Research, Systems Engineering and Industrial Engineering Commons^™

Stress Shielding In Cemented Hip Implants Assessed From Computed Tomography, Bharadwaj Cheruvu, Indresh Venkatarayappa, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Background: Aseptic loosening is the major cause of revisions for hip replacement. This mode of failure is often caused by stress shielding. Stress shielding in the femur occurs when some of the loads are taken by the prosthesis and shielded from going to the bone. There is little information regarding the stress shielding among cemented hip implants. Purpose: The purpose of this study is to investigate the effect of stress shielding on the proximal femur with a femoral prosthesis. Methods: A patient had undergone open reduction and internal fixation (ORIF) due to a comminuted reversed oblique fracture of the right …

Feature-Based Discretization Of A Turbine Disk For Probabilistic Risk Assessment, Michael Thomas, Jace Carter, Lloyd Matson, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

There is an economic need to extend the useful life of jet engine rotors. Retirement-for-Cause (RFC) is a lifing method that allows for the continued operation of components passed traditional life limits. Under RFC, an extension of damage tolerance, components are deemed safe for a further service interval using non-destructive inspections (NDI) for crack like defe cts. As components are kept in-service beyond their designed service life it is essential that the probability of failure (POF), or risk, of continued service is known. Under current FAA rotor design certification practices the component POF is analyzed using a probabilistic framework focused …

Failure Analysis Of Philos Plate Construct Used For Pantalar Arthrodesis Paper Ii-Screws And Fem Simulations, Farah Hamandi, Richard T. Laughlin, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

A fractured stainless steel 3.5 mm proximal humerus internal locking system (PHILOS) plate and screws were investigated in this paper. This plate was used for ankle arthrodesis of a 68-year-old female with a right ankle deformity. Both the plate and screws were considered in this investigation. Optical and scanning electron microscopes (SEM) were used to document fracture surface characteristics, such as extensive scratching, plastic deformation, rubbed surfaces, discoloration, and pitting, along with cleavage, secondary cracking, deposits of debris, striations, and dimples. Indications of these features show that the plate failed by corrosion fatigue, however, overloading separated the screw(s) in two …

Utilizing Functional Near-Infrared Spectroscopy For Prediction Of Cognitive Workload In Noisy Work Environments, Ryan Gabbard, Mary E. Fendley, Irfaan A. Dar, Rik Warren, Nasser H. Kashou

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Occupational noise frequently occurs in the work environment in military intelligence, surveillance, and reconnaissance operations. This impacts cognitive performance by acting as a stressor, potentially interfering with the analysts’ decision-making process. We investigated the effects of different noise stimuli on analysts’ performance and workload in anomaly detection by simulating a noisy work environment. We utilized functional near-infrared spectroscopy (fNIRS) to quantify oxy-hemoglobin (HbO) and deoxy-hemoglobin concentration changes in the prefrontal cortex (PFC), as well as behavioral measures, which include eye tracking, reaction time, and accuracy rate. We hypothesized that noisy environments would have a negative effect on the participant in …

Macrodamage Accumulation Model For A Human Femur, Farah Hamandi, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

The objective of this study was to more fully understand the mechanical behavior of bone tissue that is important to find an alternative material to be used as an implant and to develop an accurate model to predict the fracture of the bone. Predicting and preventing bone failure is an important area in orthopaedics. In this paper, the macrodamage accumulation models in the bone tissue have been investigated. Phenomenological models for bone damage have been discussed in detail. In addition, 3D finite element model of the femur prepared from imaging data with both cortical and trabecular structures is delineated using …

Brain Lesions Among Orally Fed And Gastrostomy-Fed Dysphagic Preterm Infants: Can Routine Qualitative Or Volumetric Quantitative Magnetic Resonance Imaging Predict Feeding Outcomes?, Nasser H. Kashou, Irfaan Akram Dar, Mohamed A. El-Mahdy, Charles Pluto, Mark Smith, Ish K. Gulati, Warren Lo, Sudarshan R. Jadcherla

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Introduction: The usefulness of qualitative or quantitative volumetric magnetic resonance imaging (MRI) in early detection of brain structural changes and prediction of adverse outcomes in neonatal illnesses warrants further investigation. Our aim was to correlate certain brain injuries and the brain volume of feeding-related cortical and subcortical regions with feeding method at discharge among preterm dysphagic infants.

Materials and methods: Using a retrospective observational study design, we examined MRI data among 43 (22 male; born at 31.5 ± 0.8 week gestation) infants who went home on oral feeding or gastrostomy feeding (G-tube). MRI scans were segmented, and volumes of brainstem, …

Probabilistic Analysis Of Wear Of Polymer Material Used In Medical Implants, V. Perel, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Probabilistic methods are applied to the study of fatigue wear of sliding surfaces. A variance of time to failure (to occurrence of maximum allowable wear depth) is evaluated as a function of a mean wear rate of normal wear and a size of wear particles. A method of estimating probability of failure-free work during a certain time interval (reliability) is presented. An effect of the bedding-in phase of wear on the reliability is taken into account. Experimental data for Ultra High Molecular Weight Polyethylene (UHMWPE) cups of artificial hip implants is used to make numerical calculations.

Somatic Stimulation Causes Frontoparietal Cortical Changes In Neonates: A Functional Near-Infrared Spectroscopy Study, Nasser H. Kashou, Irfaan Akram Dar, Kathryn Hasenstab, Ramzi W. Nahhas, Sudarshan R. Jadcherla

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Palmar and plantar grasp are the foremost primitive neonatal reflexes and functions. Persistence of these reflexes in infancy is a sign of evolving cerebral palsy. Our aims were to establish measurement feasibility in a clinical setting and to characterize changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbD) concentration in the bilateral frontoparietal cortex in unsedated neonates at the crib-side using functional near-infrared spectroscopy (fNIRS). We hypothesized that bilateral concentration changes will occur upon somatic central and peripheral somatic stimulation. Thirteen preterm neonates (five males) underwent time 1, and six (two males) returned for time 2 (mean PMA ¼ 41.6 and 47.0 …

Quantitative Analysis Of Retrieved Glenoid Liners, Katelyn Childs, Lynn Crosby, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Revision of orthopedic surgeries is often expensive and involves higher risk from complications. Since most total joint replacement devices use a polyethylene bearing, which serves as a weak link, the assessment of damage to the liner due to in vivo exposure is very important. The failures often are due to excessive polyethylene wear. The glenoid liners are complex and hemispherical in shape and present challenges while assessing the damage. Therefore, the study on the analysis of glenoid liners retrieved from revision surgery may lend insight into common wear patterns and improve future product designs. The purpose of this pilot study …

Long-Term Velaglucerase Alfa Treatment In Children With Gaucher Disease Type 1 Naïve To Enzyme Replacement Therapy Or Previously Treated With Imiglucerase, Laurie Smith, William Rhead, Joel Charrow, Suma P. Shankar, Ashish Bavdekar, Nicola Longo, Rebecca Mardach, Paul Harmatz, Thomas N. Hangartner, Hak-Myung Lee, Eric Crombez, Gregory M. Pastores

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Background

Gaucher Disease type 1 (GD1) often manifests in childhood. Early treatment with enzyme replacement therapy (ERT) may prevent disease complications. We report the assessment of velaglucerase alfa ERT in pediatric GD1 patients who participated in a long-term extension study (HGT-GCB-044, ClinicalTrials.gov Identifier NCT00635427).

Methods

Safety and efficacy were evaluated in pediatric patients receiving velaglucerase alfa 30–60 U/kg by intravenous infusion every other week. In addition to key hematological and visceral efficacy assessments, exploratory assessments conducted specifically in pediatric patients included evaluation of height, bone age, bone marrow burden, and Tanner stage of puberty.

Results

The study included 24 …

Stimulus And Optode Placement Effects On Functional Near-Infrared Spectroscopy Of Visual Cortex, Nasser H. Kashou, Brenna M. Giacherio

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Functional near-infrared spectroscopy has yet to be implemented as a stand-alone technique within an ophthalmology clinical setting, despite its promising advantages. The present study aims to further investigate reliability of visual cortical signals. This was achieved by: (1) assessing the effects of optode placements using the 10–20 International System of Electrode Placement consisting of 28 channels, (2) determining effects of stimulus size on response, and (3) evaluating response variability as a result of cap placement across three sessions. Ten participants with mean age 23.8 4.8 years (five male) and varying types of hair color and thickness were recruited. Visual stimuli …

Analysis Of A Clinically Failed, Mechanically Intact, Hemi-Toe Implant, Swetha Varadharajan, Richard T. Laughlin, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

In this case study a clinically failed, mechanically intact, hemi-toe device was investigated. The clinical indication of the failure constitutes radiolucent line indicating loosening of the implant and possible interactions among the bone-implant initiated by osteolysis may become a factor, producing pain, inflammatory reactions, deformity and discomfort. The patient file was not available to determine these parameters. The device was titanium coated, Cobalt Chromium alloy used for making hemi-toe. Degeneration of hemi implant was due to spalling of the coating from the surface, causing loosening of stem from bone. However, pre-removal X-ray films were not available to confirm. Mechanism by …

Hand-Grasping And Finger Tapping Induced Similar Functional Near-Infrared Spectroscopy Cortical Responses, Nasser H. Kashou, Brenna M. Giacherio, Ramzi W. Nahhas, Sudarshan R. Jadcherla

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Despite promising advantages such as low cost and portability of functional near-infrared spectroscopy (fNIRS), it has yet to be widely implemented outside of basic research. Specifically, fNIRS has yet to be proven as a standalone tool within a clinical setting. The objective of this study was to assess hemodynamic concentration changes at the primary and premotor motor cortices as a result of simple whole-hand grasping and sequential finger-opposition (tapping) tasks. These tasks were repeated over 3 days in a randomized manner. Ten healthy young adults (23.8 4.8 years) participated in the study. Quantitatively, no statistically significant differences were discovered between …

Finite Element Analysis Of Superior C3 Cervical Vertebra Endplate And Cancellous Core Under Static Loads, Isaac Mabe, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Subsidence is a type of failure associated with implanted cervical cages or artificial intervertebral discs. It is defined as a loss of postoperative disc height. Actuarial rates show a risk of subsidence at 16 weeks at 70.7 percent. This study examines the changes in the vertebral endplate morphology and the resulting effect on the stresses developed in the endplate and in the vertebral core. A three-dimensional linear elastic model was created from computed tomographic (CT) scans and material properties were assigned according to various studies. Particular care was taken in the superior endplate that was modeled according to experimental measurements. …

Analysis Of A Clinically Failed, Mechanically Intact, Reconstructive Compression Plate, Bharadwaj Cheruvu, Sunil Karmacharya, Richard T. Laughlin, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

A reconstructive orthopedic bone plate was submitted for analysis. Traditional failure analysis methods were used to assess the mode of the plate failure. Metallographic investigation of the plate was carried out in this report. Since limited data was available in the literature and clinical data related to subject demography, date of removal as well as reasons for removal unknown, in depth analysis was not possible. However, the plate was received in in-tact condition with minor biological deposits and scratches, it is speculated that the failure of the plate may have been due to biological/clinical reasons, likely infection, rejecting the device …

Velaglucerase Alfa (Vpriv) Enzyme Replacement Therapy In Patients With Gaucher Disease: Long-Term Data From Phase Iii Clinical Trials, Derralynn A. Hughes, Derlis Gonzalez, Elena A. Lukina, Atul Mehta, Madhulika Kabra, Deborah Elstein, Isaac Kisinovsky, Pilar Giraldo, Ashish Bavdekar, Thomas N. Hangartner, Nan Wang, Eric Crombez, Ari Zimran

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Type 1 Gaucher disease is an inherited lysosomal enzyme deficiency with variable age of symptom onset. Common presenting signs include thrombocytopenia, anemia, hepatosplenomegaly, bone abnormalities, and, additionally in children, growth failure. Fifty-seven patients aged 3–62 years at the baseline of two phase III trials for velaglucerase alfa treatment were enrolled in the single extension study. In the extension, they received every-other-week velaglucerase alfa intravenous infusions for 1.2–4.8 years at 60 U/kg, although 10 patients experienced dose reduction. No patient experienced a drug-related serious adverse event or withdrew due to an adverse event. One patient died following a convulsion that was …

Safety And Efficacy Results Of Switch From Imiglucerase To Velaglucerase Alfa Treatment In Patients With Type 1 Gaucher Disease, Deborah Elstein, Atul Mehta, Derralynn A. Hughes, Pilar Giraldo, Joel Charrow, Laurie Smith, Suma P. Shankar, Thomas N. Hangartner, Yune Kunes, Nan Wang, Eric Crombez, Ari Zimran

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Gaucher disease (GD) is a lysosomal storage disorder; symptomatic patients with type 1 GD need long-term disease-specific therapy of which the standard of care has been enzyme replacement therapy (ERT). Thirty-eight of 40 patients (aged 9–71 years) clinically stable on ERT with imiglucerase, safely switched to a comparable dose of velaglucerase alfa (units/kg) during TKT034, a 12-month, open-label clinical study, and for 10–50 months in an extension study. The most common adverse events (AEs) judged to be drug-related in the extension were fatigue and bone pain. No drug-related serious AEs were reported. No AEs led to study withdrawal. At 24 …

Toe Joint Replacement Models, Tarun Goswami, Allison L. Van Horn, Alexander O. Sheets

Biomedical, Industrial & Human Factors Engineering Faculty Publications

In various embodiments, provided are implantable devices for replacing all or a portion of a metatarsophalangeal joint, comprising (i) a metatarsal component comprising a Substan tially convex bearing Surface; or (ii) a phalanx component comprising a Substantially concave bearing Surface; or (iii) both. In various embodiments, also provided are methods of treating hallux Valgus by replacing all or a portion of a meta tarsophalangeal joint with one or more of the provided implantable devices.

Oculomotor Neurocircuitry, A Structural Connectivity Study Of Infantile Nystagmus Syndrome, Nasser H. Kashou, Angelica R. Zampini

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Infantile Nystagmus Syndrome (INS) is one of the leading causes of significant vision loss in children and affects about 1 in 1000 to 6000 births. In the present study, we are the first to investigate the structural pathways of patients and controls using diffusion tensor imaging (DTI). Specifically, three female INS patients from the same family were scanned, two sisters and a mother. Six regions of interest (ROIs) were created manually to analyze the number of tracks. Additionally, three ROI masks were analyzed using TBSS (Tract-Based Spatial Statistics). The number of fiber tracks was reduced in INS subjects, compared to …

A Probabilistic Fracture Assessment Of Vertebral Cortical Bone, Tarun Goswami, Isaac Mabe

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Cortical bone is a material with a porous structure. The presence of pores creates local stress concentrations and the likelihood of premature failure. Assuming that pores are present in all bone, vertebral endplates, for example, can subside. Subsidence has taken place at rates as high as 77 percent. A computational probabilistic assessment of the pore size distribution and their contribution to the fracture toughness has been presented in this paper. A Monte Carlo simulation was used to develop and assign random pores. Also the model compared crack sizes to the thickness of the cortical bone present as a limiting case. …

Wear Characteristics Of Wright State University Total Ankle Replacement Under Shear And Torsion Loads, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Introduction: Total ankle replacement (TAR) involves replacement of the damaged bone with prosthetic components and is usually performed in patients suffering with arthritis to relieve pain and maintain motion. There are several different factors that contribute to failure of TARs but aseptic loosening is the primary method of failure in total ankle replacements. Because of its superior mechanical properties UHMWPE is used as a liner material in TARs. Wear generated from the liner due to high contact stresses during gait causes osteolysis resulting in early loosening of the prostheses.

Most of the earlier studies have focused on wear due to …

Effect Of Anthropometric Adjustments On Bmd And Bmc Z-Scores In A Population Of Prader-Willi Syndrome Pediatric Patients, Amanda E. Marker, David F. Short, Talia Eldar-Geva, Harry J. Hirsch, Varda Gross-Tsur, Maayan Tiomkin, Ari Zimran, Thomas N. Hangartner

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Two adjustment models were applied to a dataset of bone-mineral density (BMD) and bone-mineral content (BMC) from dual-energy x-ray absorptiometry (DXA) measurements of pediatric patients with Prader-Willi Syndrome (PWS). One model used weight, height and % body fat (WHF) in the calculation of Z-scores in addition to race, sex and age already included in the standard model. As percent body fat is not always available, a second model with only weight and height was also examined (WH).

A Practical Guide To An Fmri Experiment, Nasser H. Kashou

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Functional Magnetic Resonance Imaging (fMRI) has been around for two decades and research in this field has been exponentially rising. Much of this research has been dominated by basic science. Recent trends have brought the clinical realm into play in which valuable contributions can still be made. Helping the clinician understand the basic concepts behind an fMRI experiment is crucial to further developing and evaluating functional paradigms and research. Critical to designing an fMRI experiment is understanding the related physics and how fine tuning scanning parameters affects the image quality, which in turn affect the findings of an fMRI study. …

Rheological Model Of Force Transmission Through The Helmet And Concussion Sensitivity, Isiah Kendall, Anthony Vicini, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

In contact sports, head-to-head collisions can lead to concussions, which pose serious health risks to players. This research aims to understand the force transfer from the helmet to the brain that causes concussions in collisions using a rheological model. Experimental data was gathered from players in the National Football League and testing of one type of helmet and padding. The rheological model was verified with published data and good correlation was achieved. Further sensitivity analysis of concussion risk was performed with respect to force, body weight, mass, and impact duration fit to normal and Weibull distributions using Monte Carlo simulations …

Interpolation-Based Super-Resolution Reconstruction: Effects Of Slice Thickness, Amir Pasha Mahmoudzadeh, Nasser H. Kashou

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Standard clinical magnetic resonance imaging (MRI) is acquired in two-dimensions where the in-plane resolution is higher than the slice select direction. These acquisitions include axial, coronal, and sagittal planes. To date, there have been few attempts to combine the information of these three orthogonal orientations. This paper aims to take advantage of the different in-plane resolution acquired from each plane orientation and combine them into one volume in order to attain a higher resolution image. This combination of MRI data will allow the detection of smaller areas that would otherwise be missed using only one slice orientation. A comparison of …

Evaluation Of Interpolation Effects On Upsampling And Accuracy Of Cost Functions-Based Optimized Automatic Image Registration, Amir Pasha Mahmoudzadeh, Nasser H. Kashou

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Interpolation has become a default operation in image processing and medical imaging and is one of the important factors in the success of an intensity-based registration method. Interpolation is needed if the fractional unit of motion is not matched and located on the high resolution (HR) grid. The purpose of this work is to present a systematic evaluation of eight standard interpolation techniques (trilinear, nearest neighbor, cubic Lagrangian, quintic Lagrangian, hepatic Lagrangian, windowed Sinc, B-spline 3rd order, and B-spline 4th order) and to compare the effect of cost functions (least squares (LS), normalized mutual information (NMI), normalized cross correlation (NCC), …

Toe Brace Designs, Tarun Goswami, Allison L. Van Horn, Alexander O. Sheets

Biomedical, Industrial & Human Factors Engineering Faculty Publications

In various embodiments, provided are braces for use in supporting the metatarophalangeal joint, reducing or maintaining the intermetatarsal angle, enhancing or maintaining alignment of the hallux, or combinations thereof in a subject having hallux valgus.

Current Trends Of Fmri In Vision Science: A Review, Nasser H. Kashou

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Studying brain functional activities is an area that is experiencing rapid interest in the field of neuroimaging. Functional magnetic resonance imaging (fMRI) has provided vision science researchers a powerful and noninvasive tool to understand eye function and correlate it with brain activities. In this chapter, we focus on the physiological aspects followed by a literature review. More specifically, to motivate and appreciate the complexity of the visual system, we will begin with a description of specific stages the visual pathway, beginning from the distal stimulus and ending in the visual cortex. More importantly, the development of ascending visual pathway will …

New Window On Optical Brain Imaging; Medical Development, Simulations And Applications, Chemseddine Mansouri, Nasser H. Kashou

Biomedical, Industrial & Human Factors Engineering Faculty Publications

In this chapter we hope to give a technological review of near-infrared light and systems, discuss optode design considerations including background on the fiber design as it relates to this field and finally touch on current trends and applications. For the latter, we will focus on diffusion theory and simulation of photon propagation using a head model. We will follow this with concluding remarks.

Revised Reference Curves For Bone Mineral Content And Areal Bone Mineral Density According To Age And Sex For Black And Non-Black Children: Results Of The Bone Mineral Density In Childhood Study, Babette S. Zemel, Heidi J. Kalkwarf, Vicente Gilsanz, Joan M. Lappe, Sharon Oberfield, John A. Shepherd, Margaret M. Frederick, Xangke Huang, Ming Lu, Soroosh Mahboubi, Thomas N. Hangartner, Karen K. Winer

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Context: Deficits in bone acquisition during growth may increase fracture risk. Assessment of bone health during childhood requires appropriate reference values relative to age, sex, and population ancestry to identify bone deficits.

Objective: The objective of this study was to provide revised and extended reference curves for bone mineral content (BMC) and areal bone mineral density (aBMD) in children.

Design: The Bone Mineral Density in Childhood Study was a multicenter longitudinal study with annual assessments for up to 7 yr.

Setting: The study was conducted at five clinical centers in the United States.

Participants: Two thousand fourteen healthy children (992 …