Operations Research, Systems Engineering and Industrial Engineering Commons^™

In-Vivo Damage Development In Vena Cava Filter: Study Of A Retrieved Device, Anne Marie Lutz, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

This article was prepared from a project assigned in a graduate class, BME 7371, Failure Assessment of Medical Devices, taught at Wright State University by the senior author. The device was donated for the study which was successfully retrieved after 93 days in-vivo. Even-though the mechanical integrity of the device held in-tact, the microscopic observations revealed that the damage via corrosion and scratching took place on the surface of the device. The image reconstructed in 3D using image-J software to determine device roughness and depth-of-pits. Results presented in this paper show that damage starts developing in these devices after the …

Mechanical Properties Of Nanoparticles In The Drug Delivery Kinetics, Kaivon Assani, Amy Neidhard-Doll, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Nanoparticle formulation is a recently developed drug delivery technology with enhanced targeting potential. Nanoparticles encapsulate the drug of choice and delivers it to the target via a targeting molecules (ex. antigen) located on the nanoparticle surface. Nanoparticles can even be targeted to deeply penetrating tissue and can be modeled to deliver drugs through the blood brain barrier. These advancements are providing better disease targeting such as to cancer and Alzheimer’s. Various polymers can be manufactured into nanoparticles. The polymers examined in this paper are polycaprolactone (PCL), poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), and poly(glycolic acid) (PGA). The purpose of this …

Nanoparticulate Carriers For Drug Delivery, Samantha Lokelani Crossen, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Drug delivery with nanoparticulate carriers is a new and upcoming research area that is making major changes within the pharmaceutical industry. Nanoparticulate carriers are discussed, particularly, engineered nanoparticulate carriers used as drug delivery systems for targeted delivery. Nanoparticulate carriers that are used for drug delivery systems include polymers, micelles, dendrimers, liposomes, ceramics, metals, and various forms of biological materials. The properties of these nanoparticulate carriers are very advantageous for targeted drug delivery and result in efficient drug accumulation at the targeted area of interest, reduced drug toxicity, reduced systemic side effects, and more efficient use of the drug overall. Nanoparticlulate …

Advancing Ubiquitous Collaboration For Telehealth - A Framework To Evaluate Technology-Mediated Collaborative Workflow For Telehealth, Hypertension Exam Workflow Study, Christopher Bondy Ph.D., Linlin Chen Ph.D, Pamela Grover Md, Pengcheng Shi Ph.D

Articles

Healthcare systems are under siege globally regarding technology adoption; the recent pandemic has only magnified the issues. Providers and patients alike look to new enabling technologies to establish real-time connectivity and capability for a growing range of remote telehealth solutions. The migration to new technology is not as seamless as clinicians and patients would like since the new workflows pose new responsibilities and barriers to adoption across the telehealth ecosystem. Technology-mediated workflows (integrated software and personal medical devices) are increasingly important in patient-centered healthcare; software-intense systems will become integral in prescribed treatment plans [1]. My research explored the path to …

Biomechanical Evaluation Of Recurrent Dissociation Of Modular Humeral Prostheses, Daniel B. Luckenbill, Mike F. Iossi, Alyssa M. George Whitney, Danielle Miller, Lynn A. Crosby, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

The purpose of the study was to evaluate the force and torque required to dissociate a humeral head from the unimplanted modular total shoulder replacement system from different manufacturers and to determine if load and torque to dissociation are reduced in the presence of bodily fluids. Impingement, taper contamination, lack of compressive forces, and interference of taper fixation by the proximal humerus have all been reported as possible causes for dissociation. Experimental values determined in this research were compared with literature estimates of dissociation force of the humeral head under various conditions to gain more understanding of the causes of …

Transdermal Drug Delivery Systems: Analysis Of Adhesion Failure, Zachary Brooks, Tushar Goswami, Amy Neidhard-Doll, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

The most critical component of the TDDS is the adhesive, which is responsible for the safety, efficacy and quality of the patch. For drug delivery to successfully occur, the patch must adhere to the surface of the contact area. If a patch has inadequate adhesion, it is likely to fall off before the entire delivery period has been satisfied, leading to risks for the patient and others who may encounter the patch. Despite the critical concerns associated with the adhesive properties of the patches, the adhesion quality and failure mechanisms have not been fully studied. If certain molecules encounter the …

Retrospective Evaluation And Framework Development Of Bone Anisotropic Material Behavior Compared With Elastic, Elastic-Plastic, And Hyper-Elastic Properties, Farah Hamandi, James T. Tsatalis, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

The main motivation for studying damage in bone tissue is to better understand how damage develops in the bone tissue and how it progresses. Such knowledge may help in the surgical aspects of joint replacement, fracture fixation or establishing the fracture tolerance of bones to prevent injury. Currently, there are no standards that create a realistic bone model with anisotropic material properties, although several protocols have been suggested. This study seeks to retrospectively evaluate the damage of bone tissue with respect to patient demography including age, gender, race, body mass index (BMI), height, and weight, and their role in causing …

Cyclic Damage Accumulation In The Femoral Constructs Made With Cephalomedullary Nails, Farah Hamandi, Alyssa Whitney, Mark H. Stouffer, Michael J. Prayson, Jorn Rittweger, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Background: The purpose of this study was to evaluate the risk of peri-prosthetic fracture of constructs made with cephalomedullary (CM) long and short nails. The nails were made with titanium alloy (Ti-6Al-4V) and stainless steel (SS 316L). Methods: Biomechanical evaluation of CM nail constructs was carried out with regard to post-primary healing to determine the risk of peri-implant/peri-prosthetic fractures. Therefore, this research comprised of, non-fractured, twenty-eight pairs of cadaveric femora that were randomized and implanted with four types of fixation CM nails resulting in four groups. These constructs were cyclically tested in bi-axial mode for up to 30,000 cycles. All …

Nebulizer-Based Systems To Improve Pharmaceutical Aerosol Delivery To The Lungs, Benjamin M. Spence

Theses and Dissertations

Combining vibrating mesh nebulizers with additional new technologies leads to substantial improvements in pharmaceutical aerosol delivery to the lungs across therapeutic administration methods. In this dissertation, streamlined components, aerosol administration synchronization, and/or Excipient Enhanced Growth (EEG) technologies were utilized to develop and test several novel devices and aerosol delivery systems. The first focus of this work was to improve the poor delivery efficiency, e.g., 3.6% of nominal dose (Dugernier et al. 2017), of aerosolized medication administration to adult human subjects concurrent with high flow nasal cannula (HFNC) therapy, a form of continuous-flow non-invasive ventilation (NIV). The developed Low-Volume Mixer-Heater (LVMH) …

Analysis Of Information Security Methods In Biosystems And Application Of Intelligent Tools In Information Security Systems, Sherzod Sayfullaev

Chemical Technology, Control and Management

In this paper, the methods of information protection in bio systems are studied. The paper considers the use of intelligent tools in information security systems and the use of adaptive information security systems. Several articles on the field of information protection in bio systems are analyzed. Disadvantages and advantages of neural network technologies in modern information security systems are described. The characteristics of bio systems and the specificity of DNA, the main features of the DNA code that provide information security and functional stability of bio systems data protection structure. Application of intelligent tools to create a comprehensive adaptive protection …

How Does Robotic Surgery Influence Communication, Leadership, And Team Outcomes? A Multimethod Examination., Jordan E. Rogers

Doctoral Dissertations and Master's Theses

The practice of delivering surgical care has evolved to be less invasive to the patients undergoing surgery. Minimally-invasive surgery can be practiced through traditional laparoscopic methods as well as with robotic technology that displaces the surgeon from the operating table. Robotic surgery has been cited to be safer and more effective than traditional laparoscopic surgery; however, little research has endeavored to investigate the role of surgical modality upon aspects of teamwork. This dissertation contributes to the human factors and teamwork literature by evaluating how surgical modality may influence communication, shared leadership, and team outcomes. Multiple methods were employed to study …

Biomechanical Behavior Of A Variable Angle Locked Tibiotalocalcaneal Construct, Farah Hamandi, Gerard Simon, Richard T. Laughlin, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

This paper examines the mechanics of the tibiotalocalcaneal construct made with a PHILOS plating system. A failed device consisting of the LCP plate and cortical, locking, and cannulated screws was used to perform the analysis. Visual, microstructure, and fractographic examinations were carried out to characterize the fracture surface topology. These examinations revealed the presence of surface scratching, inclusions, discoloration, corrosion pits, beach marks, and cleavage and striations on the fracture surface. Further examination of the material crystallography and texture revealed an interaction of S, Ni, and Mo-based inclusions that may have raised pitting susceptibility of the device made with Stainless …

Comparison Of Hybridizing Options For Solar Heat, Biomass And Heat Storage For Electricity Generation In Spain, Cm Iftekhar Hussain, Brian Norton, Aidan Duffy

Articles

Diurnal and seasonal variations of direct solar energy circumscribe locations suitable for sole use of concentrated solar power for electricity generation, whereas to generate electricity at night and during winter months, biomass systems can be used that incur fuel expenditures and may encounter fuel supply discontinuities. Combining solar heat, biomass conversion and heat storage in a hybrid electricity generation plant may overcome the limitations of sole use of any one of these energy sources in specific geographic and/or economic conditions. In this work standalone biomass, hybrid concentrated solar power-biomass and hybrid concentrated solar power-biomass-thermal energy storage power generation systems are …

Investigation Of Retrieved Cardiac Devices, Anmar Salih, Iosif Papadakis Ktistakis, Spyridon Manganas, Abdul Wase, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Damage assessment of lead and pulse generator with various exposure times is important in the development of cardiac devices. Approximately, 92.1 million patients in the US suffer from cardiovascular diseases with an estimated healthcare cost of over $300 billion and at least one million with implantable cardiac devices. These devices are complex and composed on multiple levels and present challenges while assessing the damage. However, the study on the analysis of cardiac devices may lend insight into common damage patterns and improve future cardiac devices design. The objective of this work is to perform a thorough in vivo damage assessment …

Investigation Of A Neuro-Stimulator Retrieved Posthumously, Megan Markl, Rodney J. Gutherie, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

A neurostimulator was investigated in this paper posthumously. Device was presented to our anatomical gift program. Investigation was multi-fold and contained visual inspection, using an optical microscope, and mechanical and electrical testing of leads and its insulator. It was concluded that the device could have been damaged during implantation, in vivo, during removal, and/or during transportation to author’s laboratories. The damage observed on the lead insulation is similar to that which can occur due to anchoring of the lead and hardening due to oxidation. Insulation stiffness was determined to be 1/10 of new insulator. The results reported here on the …

Simulation Of Skull Fracture Due To Falls, Anthony Vicini, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

This study presents novel predictive equations for von Mises stress values of bones in the frontal and lateral regions of the skull. The equations were developed based on results of a finite element model developed during this research. The model was validated for frontal and lateral loading conditions with input values mimetic to fall scenarios. Using neural network processing of the information derived from the model achieved R2 values of 0.9990 for both the stress and deflection. Based on the outcome of the fall victims, a threshold von Mises stress of 40.9 to 46.6 MPa was found to indicate skull …

Deep Brain Stimulation: Prediction Model For Volume Of Tissue Stimulated, Melissa Jones, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

An attempt has been made to understand deep brain stimulation in humans via marketable devices that are approved by the US Food and Drug Administration. The electrode characteristics were presented to influence the volume of tissue stimulated. Experimental data were digitized and VTS data were presented a function of electrode diameter, aspect ratio, applied current, pulse duration, voltage and frequency. Amongst other trends voltage and VTS were found to exhibit a three-stage relation, where Stage II characteristics were represented by a linear equation. It is in this stage, the VTS was found to be stable and where the most effective …

Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, Mohammed Ali

Mohammed Ali

The dry powder inhaler (DPI) is a popular, effective and convenient drug delivery device for inhalation therapy to treat asthma. However, a large quantity (approximately 54%) of inhaled aerosols deposit in the oropharyngeal region. Deposition in this region is undesirable because it provides minimum therapeutic benefits and has adverse localized or systemic side effects. This study reports a method of examining electrostatic charge effects on deposition of three DPI aerosols (Spiriva^™ Handihaler, Advair Diskus^™, and Pulmicort^™ Turbohaler) in a cadaver-based cast of the human oral-pharyngeal-laryngeal (OPL) regions. Experimental aerosols were generated from the three commercially available …

Automatic Methods To Enhance The Quality Of Colonoscopy Video, Nidhal Kareem Shukur Azawi

Graduate Theses and Dissertations

Colonoscopy is a form of endoscopy because it uses colonoscopy device to help the doctor to understand a colon patient. Enhancing the quality of Colonoscopy images is a challenge because of the wet and dynamic environment inside the colon causes many problems even the colonoscope devise has a good quality. Some of these problems are blurriness, specular highlights shiny areas.

In this work, different kinds of techniques have been investigated in order to improve the quality of colonoscopy images. Also, variety of preprocessing approaches (removing bad images, resizing images, median filtration with and without image resizing) have been conducted to …

Challenges Of Erau’S First Suborbital Flight Aboard Blue Origin’S New Shepard M7 For The Cell Research Experiment In Microgravity (Crexim), Pedro Llanos, Kristina Andrijauskaite, Vijay V. Duraisamy, Francisco F. Pastrana, Erik Seedhouse, Sathya Gangadharan, Leonid Bunegin, Mariel Rico

Pedro J. Llanos (www.AstronauticsLlanos.com)

Stress Shielding In Cemented Hip Implants Assessed From Computed Tomography, Bharadwaj Cheruvu, Indresh Venkatarayappa, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Background: Aseptic loosening is the major cause of revisions for hip replacement. This mode of failure is often caused by stress shielding. Stress shielding in the femur occurs when some of the loads are taken by the prosthesis and shielded from going to the bone. There is little information regarding the stress shielding among cemented hip implants. Purpose: The purpose of this study is to investigate the effect of stress shielding on the proximal femur with a femoral prosthesis. Methods: A patient had undergone open reduction and internal fixation (ORIF) due to a comminuted reversed oblique fracture of the right …

Interventions Of Waterjet Technology In Skin Incisions, Nadi Atalla

Dissertations

This research explores the use of waterjet (WJ) technology in performing skin incisions. The study defines the analytical relationships between the skin properties and the operating parameters of the WJ which include the skin thickness, its elastic modulus, the WJ pressure, the nozzle’s orifice diameter, its stand-off distance and the traverse speed of the WJ as well as the duration of applying the WJ pressure. An analytical model is developed to measure the depth incision of the skin, the water pressure and the water velocity, while using a WJ. Systemization and optimization models that determine the optimal operating parameters levels …

Development Of A Myoelectric Detection Circuit Platform For Computer Interface Applications, Nickolas Andrew Butler

Master's Theses

Personal computers and portable electronics continue to rapidly advance and integrate into our lives as tools that facilitate efficient communication and interaction with the outside world. Now with a multitude of different devices available, personal computers are accessible to a wider audience than ever before. To continue to expand and reach new users, novel user interface technologies have been developed, such as touch input and gyroscopic motion, in which enhanced control fidelity can be achieved. For users with limited-to-no use of their hands, or for those who seek additional means to intuitively use and command a computer, novel sensory systems …

The Subject Librarian Newsletter, Engineering And Computer Science, Fall 2017, Buenaventura "Ven" Basco

Buenaventura "Ven" Basco

No abstract provided.

Feature-Based Discretization Of A Turbine Disk For Probabilistic Risk Assessment, Michael Thomas, Jace Carter, Lloyd Matson, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

There is an economic need to extend the useful life of jet engine rotors. Retirement-for-Cause (RFC) is a lifing method that allows for the continued operation of components passed traditional life limits. Under RFC, an extension of damage tolerance, components are deemed safe for a further service interval using non-destructive inspections (NDI) for crack like defe cts. As components are kept in-service beyond their designed service life it is essential that the probability of failure (POF), or risk, of continued service is known. Under current FAA rotor design certification practices the component POF is analyzed using a probabilistic framework focused …

Fixing Vertebral Compression Fractures With Medtronic, Kelly Fitzgerald, Trevor Bingham, Alex Denbaugh, Jordan Tang, Jon Stearns

Industrial and Manufacturing Engineering

No abstract provided.

Design Of A Distributed Real-Time E-Health Cyber Ecosystem With Collective Actions: Diagnosis, Dynamic Queueing, And Decision Making, Yanlin Zhou

Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research

In this thesis, we develop a framework for E-health Cyber Ecosystems, and look into different involved actors. The three interested parties in the ecosystem including patients, doctors, and healthcare providers are discussed in 3 different phases. In Phase 1, machine-learning based modeling and simulation analysis is performed to remotely predict a patient's risk level of having heart diseases in real time. In Phase 2, an online dynamic queueing model is devised to pair doctors with patients having high risk levels (diagnosed in Phase 1) to confirm the risk, and provide help. In Phase 3, a decision making paradigm is proposed …

Failure Analysis Of Philos Plate Construct Used For Pantalar Arthrodesis Paper Ii-Screws And Fem Simulations, Farah Hamandi, Richard T. Laughlin, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

A fractured stainless steel 3.5 mm proximal humerus internal locking system (PHILOS) plate and screws were investigated in this paper. This plate was used for ankle arthrodesis of a 68-year-old female with a right ankle deformity. Both the plate and screws were considered in this investigation. Optical and scanning electron microscopes (SEM) were used to document fracture surface characteristics, such as extensive scratching, plastic deformation, rubbed surfaces, discoloration, and pitting, along with cleavage, secondary cracking, deposits of debris, striations, and dimples. Indications of these features show that the plate failed by corrosion fatigue, however, overloading separated the screw(s) in two …

Utilizing Functional Near-Infrared Spectroscopy For Prediction Of Cognitive Workload In Noisy Work Environments, Ryan Gabbard, Mary E. Fendley, Irfaan A. Dar, Rik Warren, Nasser H. Kashou

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Occupational noise frequently occurs in the work environment in military intelligence, surveillance, and reconnaissance operations. This impacts cognitive performance by acting as a stressor, potentially interfering with the analysts’ decision-making process. We investigated the effects of different noise stimuli on analysts’ performance and workload in anomaly detection by simulating a noisy work environment. We utilized functional near-infrared spectroscopy (fNIRS) to quantify oxy-hemoglobin (HbO) and deoxy-hemoglobin concentration changes in the prefrontal cortex (PFC), as well as behavioral measures, which include eye tracking, reaction time, and accuracy rate. We hypothesized that noisy environments would have a negative effect on the participant in …

The Subject Librarian Newsletter, Engineering And Computer Science, Fall 2017, Buenaventura "Ven" Basco

Libraries' Newsletters

No abstract provided.