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The Microfluidic Intravital Window : A Tool For Manipulation And Imaging Of The Tumor Microenvironment, Logan William Butt

Legacy Theses & Dissertations (2009 - 2024)

The tumor microenvironment (TME) is a heterogeneous collection of both healthy and pathological cells, whose complex interactions hold the key for understanding and overcoming cancer. Metastasis leverages these complex interactions into a sophisticated process by which single cells from the tumor disseminate into the blood and form new colonies in other organ systems. Subsequent formation of tumors throughout the body, as a direct result of metastatic events, is responsible for most deaths related to cancer, making metastasis a necessary target for cancer therapy.