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Full-Text Articles in Mechanical Engineering
Model-Based Network Reconstruction From Cascade Dynamics, Katherine Irena Chwistek
Model-Based Network Reconstruction From Cascade Dynamics, Katherine Irena Chwistek
Graduate Research Theses & Dissertations
Network representation provides a natural framework for the study of real world complex systems. From social networks and animal groups to interneuronal communications and power grid systems, complex patterns of interaction can be captured and modeled using networks in a simple mathematical form. In many cases, however, a faithful network representation of the system is not readily available. For this reason, network reconstruction has become a growing topic of interest in recent years, the goal of which is to discover the hidden interaction patterns among individuals by fitting input-output data from multiple experiments to candidate network topologies.
During a cascade, …
Mitochondrial Dynamics And Respiration Within Cells With Increased Open Pore Cytoskeletal Meshes, David H. Jang, Sarah C. Seeger, Martha E. Grady, Frances S. Shofer, David M. Eckmann
Mitochondrial Dynamics And Respiration Within Cells With Increased Open Pore Cytoskeletal Meshes, David H. Jang, Sarah C. Seeger, Martha E. Grady, Frances S. Shofer, David M. Eckmann
Mechanical Engineering Faculty Publications
The cytoskeletal architecture directly affects the morphology, motility, and tensional homeostasis of the cell. In addition, the cytoskeleton is important for mitosis, intracellular traffic, organelle motility, and even cellular respiration. The organelle responsible for a majority of the energy conversion for the cell, the mitochondrion, has a dependence on the cytoskeleton for mobility and function. In previous studies, we established that cytoskeletal inhibitors altered the movement of the mitochondria, their morphology, and their respiration in human dermal fibroblasts. Here, we use this protocol to investigate applicability of power law diffusion to describe mitochondrial locomotion, assessment of rates of fission and …