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Full-Text Articles in Mechanical Engineering
A Review Of Injectable And Implantable Biomaterials For Treatment And Repair Of Soft Tissues In Wound Healing, Shih-Feng Chou, Simi Gunaseelan, Mhd Hussam Hijazi Kiellani, Venkata Vamsi Krishna Thottempudi, Pierre Neuenschwander, Huarong Nie
A Review Of Injectable And Implantable Biomaterials For Treatment And Repair Of Soft Tissues In Wound Healing, Shih-Feng Chou, Simi Gunaseelan, Mhd Hussam Hijazi Kiellani, Venkata Vamsi Krishna Thottempudi, Pierre Neuenschwander, Huarong Nie
Mechanical Engineering Faculty Publications and Presentations
The two major topics concerning the development of nanomedicine are drug delivery and tissue engineering.With the advance in nanotechnology, scientists and engineers now have the ability to fabricate functional drug carriers and/or biomaterials that deliver and release drugs locally as well as promote tissue regeneration. In this short review, we address the use of nanotechnology in the fabrication of biomaterials (i.e., nanoparticles and nanofibers) and their therapeutic function in wound healing as dressing materials. Furthermore, we discuss the use of surface nanofeatures to regulate cell adhesion, migration, proliferation, and differentiation, which is a crucial step in wound healing associated with …
In Vivo Pharmacological Evaluations Of Pilocarpine-Loaded Antioxidant-Functionalized Biodegradable Thermogels In Glaucomatous Rabbits, Shih-Feng Chou, Li-Jyuan Luo, Jui-Yang Lai
In Vivo Pharmacological Evaluations Of Pilocarpine-Loaded Antioxidant-Functionalized Biodegradable Thermogels In Glaucomatous Rabbits, Shih-Feng Chou, Li-Jyuan Luo, Jui-Yang Lai
Mechanical Engineering Faculty Publications and Presentations
To alleviate oxidative stress-induced ocular hypertension, grafting of antioxidant molecules to drug carriers enables a dual-function mechanism to effectively treat glaucomatous intraocular pressure (IOP) dysregulation. Providing potential application for intracameral administration of antiglaucoma medications, this study, for the first time, aims to examine in vivo pharmacological efficacy of pilocarpine-loaded antioxidant-functionalized biodegradable thermogels in glaucomatous rabbits. A series of gallic acid (GA)-grafted gelatin-g-poly(N-isopropylacrylamide) (GN) polymers were synthesized via redox reactions at 20-50 °C. Our results showed that raising redox radical initiation reaction temperature maximizes GA grafting level, antioxidant activity, and water content at 40 °C. Meanwhile, increase in overall hydrophilicity of …