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University of Nebraska - Lincoln
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
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Mild Traumatic Brain Injury: Combined In Silico And In Vitro Studies, Yi Hua
Mild Traumatic Brain Injury: Combined In Silico And In Vitro Studies, Yi Hua
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
Mild traumatic brain injury (TBI) is a significant public health concern worldwide and has attracted significant attention due to high-impact sport as well as improvised explosive devices used in military conflicts. The earliest sign of mild TBI is associated with cognitive, behavioral and physical/somatic changes, which are commonly invisible to existing medical techniques. Thus it is essential to target mechanisms of mild TBI and its associated damage measures for earlier diagnosis/treatment and enhanced protection strategies.
In this work, the mechanism of blast-induced mild TBI was inspected through integrated in silico and in vitro models. A three-dimensional (3D) human head model …