Mechanical Engineering Commons^™

Cavitation In Vial Drop Subjected To Mechanical Shock, Houman Babazadehrokni

Electronic Theses and Dissertations

Cavitation is a phenomenon that occurs when the local pressure falls down below the critical pressure. Previous work from the Randolph lab demonstrated that protein aggregates can form when a vial of therapeutic solution is dropped onto a hard surface. The process by which this occurs is most likely shock induced cavitation. During this process, hot spots can be created with temperatures and pressures reaching thousands of Kelvin and hundreds of atmospheres, respectively, leading to degradation of protein therapeutics. This work will extend previous efforts by exploring differences generated by change in vial materials, solutions, drop methods and fill volumes. …