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Full-Text Articles in Mechanical Engineering
Cavitation In Vial Drop Subjected To Mechanical Shock, Houman Babazadehrokni
Cavitation In Vial Drop Subjected To Mechanical Shock, Houman Babazadehrokni
Electronic Theses and Dissertations
Cavitation is a phenomenon that occurs when the local pressure falls down below the critical pressure. Previous work from the Randolph lab demonstrated that protein aggregates can form when a vial of therapeutic solution is dropped onto a hard surface. The process by which this occurs is most likely shock induced cavitation. During this process, hot spots can be created with temperatures and pressures reaching thousands of Kelvin and hundreds of atmospheres, respectively, leading to degradation of protein therapeutics. This work will extend previous efforts by exploring differences generated by change in vial materials, solutions, drop methods and fill volumes. …
Cavitation In Pharmaceutical Manufacturing And Shipping, Donn Sederstrom
Cavitation In Pharmaceutical Manufacturing And Shipping, Donn Sederstrom
Electronic Theses and Dissertations
Therapeutic proteins are used to successfully treat hemophilia, Crohn's Disease, diabetes, and cancer. Recent product recalls have occurred because of sub-visible particle formation resulting from the inherent instability of proteins. It has been suggested that particle formation is associated with late stage processing steps of filling, shipping, and delivery. Previous work at the University of Denver demonstrated that fluid cavitation can generate a large number of sub-visible protein particles in ultra clean formulations, but that mitigation can be achieved with fluid property manipulation. The goal of this research was to (1) assess the risk of cavitation under common pharmaceutical manufacturing …