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Full-Text Articles in Mechanical Engineering
Atomic-Scale Analysis Of Solute Segregation Energy Into Grain Boundaries And Polycrystals, Tara Nenninger
Atomic-Scale Analysis Of Solute Segregation Energy Into Grain Boundaries And Polycrystals, Tara Nenninger
Graduate College Dissertations and Theses
Solute segregation in grain boundaries (GBs) is used in design to stabilize nanocrystalline alloys. While analyzing GB segregation energy as a spectrum allows for a more in-depth analysis of the effects of GB atomic structure on solute segregation, this method inherently ignores solute-solute interaction by nature of considering one solute at a time. Here we develop an efficient molecular statics (MS) algorithm for determining the local effect of solute-solute interaction on GB segregation. We apply this algorithm to a Σ9 (221) symmetric tilt grain boundary in a bicrystal as well as a randomly oriented polycrystal for Ni and Cu solutes …
Medical Applications Of Ultrasound: T-Cell Drug Delivery, Osteoporosis Diagnosis, And Biofilm Mitigation, Alina Karki
Medical Applications Of Ultrasound: T-Cell Drug Delivery, Osteoporosis Diagnosis, And Biofilm Mitigation, Alina Karki
Graduate College Dissertations and Theses
The ability of ultrasound to localize acoustic energy deposition and induce a biological effect within a target is examined in three novel biomedical applications: sonoporation, osteoporosis diagnosis, and biofilm mitigation.Ultrasound can excite encapsulated microbubbles, causing an acoustic cavitation effect in the vicinity of cells, temporarily increasing membrane permeability, and allowing cells to uptake foreign molecules. This non-viral transfection technique is called sonoporation. Our experimental study demonstrated that it could be effective for small interfering RNA (siRNA) delivery into an isolated mouse and human T-cells, which is a complex process despite its importance in treating numerous diseases. T-cells are non-proliferating, while …