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Full-Text Articles in Polymer and Organic Materials
Selfsame Epoxide-Amine Microparticle Systems: Investigation Of Crosslink Density, John J. Peyrefitte
Selfsame Epoxide-Amine Microparticle Systems: Investigation Of Crosslink Density, John J. Peyrefitte
Honors Theses
Epoxide-amine matrix materials containing microparticles with the same chemical composition provide a model system to study interphase formation in highly crosslinked epoxide-amine matrix materials. The epoxide monomer was varied between three different monomer systems to study the model system’s relationship with crosslink density. The same amine monomer, cure procedure, and stoichiometric ratio of epoxide and amine groups were used to prepare each type of microparticle and matrix material. The differences in the epoxide monomer structure affected the crosslink density of the unmodified matrix material, which was concluded to influence the effect of microparticle presence on crosslink density. For the unmodified …
Thiol-Induced Degradation Of Hydrogels Utilizing Multiresponsive Dithiomaleimides Crosslinkers, Kundu Thapa
Thiol-Induced Degradation Of Hydrogels Utilizing Multiresponsive Dithiomaleimides Crosslinkers, Kundu Thapa
Honors Theses
Hydrogels are hydrophilic, three-dimensional materials used as platforms for various biomedical applications such as drug delivery, biosensors, or as scaffolds in tissue engineering. The ability to degrade on demand in response to biological cues is particularly attractive whether dealing with microgels or if one aims to release an active ingredient from a scaffolding material. For instance, many cancer-remediation drug delivery platforms leverage the high concentration of glutathione, a thiol-containing tripeptide, found in cancerous cells. In this work, poly(ethylene glycol) acrylate hydrogels were fabricated using dithiomaleimide (DTM) moieties. DTMs are known to undergo thiol-exchange reactions favoring the dissolution of the hydrogel …
Tailoring Photodegradation Rates Of Acetal-Containing Polymer Networks, Michael Sandoz
Tailoring Photodegradation Rates Of Acetal-Containing Polymer Networks, Michael Sandoz
Honors Theses
In this thesis, we explore the degradation of poly (thioether acetal) thermosets via a photoinduced thiol-catalyzed ß-scission of acetal linkages incorporated as network crosslink junctions. Specifically, a library of bis-allyl acetal-containing monomers derived from para-substituted benzaldehydes was synthesized and formulated into photopolymerizable thiol-ene resins with commercially available thiol monomers. By varying the electron donating or withdrawing nature of the monomer substituent, we explored the impact of substituent effects on the rate of polymer degradation. Furthermore, we compare the results to those expected from a classical Hammett-type relationship of substituent electronic effects. FTIR was employed to track the appearance of the …