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Full-Text Articles in Polymer and Organic Materials
Development Of Biomaterials For Drug Delivery, Raquel De Castro
Development Of Biomaterials For Drug Delivery, Raquel De Castro
Graduate Theses and Dissertations
Drug delivery systems (DDS) have highly evolved in the last decades with the development of hydrogels and nanoparticles. However, high systemic uptake, side effects, low bioavailability, and encapsulation efficiency continue to be a major hurdle faced by such DDSs.
Nanoparticles and hydrogels can be specifically designed for targeted DDSs to mitigate some of the problems. This dissertation aimed to design two DDSs for ocular drug delivery and one for cancer treatment. The first project sought to develop chitosan nanoparticles (Cs-NP) using PEGDA as a copolymer to encapsulate gentamicin (GtS) for ocular drug delivery. Cs-NPs contain positive charges that can interact …
Biopolymeric Materials For Tissue Regeneration, Cell Manufacturing, And Drug Delivery, David Alfonso Castilla-Casadiego
Biopolymeric Materials For Tissue Regeneration, Cell Manufacturing, And Drug Delivery, David Alfonso Castilla-Casadiego
Graduate Theses and Dissertations
The development of materials for tissue regeneration, cell manufacturing, and drug delivery is possible by the manipulation of polymer properties and the use of three different techniques including layer-by-layer, electrospinning, and molding technique.
By applying the layer-by-layer technique over biomaterials, it is possible to develop polymeric multilayers that promote a more favorable environment for cellular functionality, increasing the possibility of improving their acceptance in the area of implantation. IRVASE demonstrated being a powerful technique that allows for a reliable characterization of the physical-chemical and thermal properties of the fabricated surfaces. This opens the possibility to monitor the design of surfaces …