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Full-Text Articles in Mechanics of Materials
Disturbed Cyclical Stretch Of Endothelial Cells Promotes Nuclear Expression Of The Pro-Atherogenic Transcription Factor Nf-Kb, Ryan M. Pedrigi, Konstantinos I. Papadimitriou, Avinash Kondiboyina, Sukhjinder Sidhu, James Chau, Miten B. Patel, Daniel C. Baeriswyl, Emmanuel M. Drakakis, Rob Krams
Disturbed Cyclical Stretch Of Endothelial Cells Promotes Nuclear Expression Of The Pro-Atherogenic Transcription Factor Nf-Kb, Ryan M. Pedrigi, Konstantinos I. Papadimitriou, Avinash Kondiboyina, Sukhjinder Sidhu, James Chau, Miten B. Patel, Daniel C. Baeriswyl, Emmanuel M. Drakakis, Rob Krams
Department of Mechanical and Materials Engineering: Faculty Publications
Exposure of endothelial cells to low and multidirectional blood flow is known to promote a pro-atherogenic phenotype. The mechanics of the vessel wall is another important mechano-stimulus within the endothelial cell environment, but no study has examined whether changes in the magnitude and direction of cell stretch can be pro-atherogenic. Herein, we developed a custom cell stretching device to replicate the in vivo stretch environment of the endothelial cell and examined whether low and multidirectional stretch promote nuclear translocation of NF-kB. A fluid–structure interaction model of the device demonstrated a nearly uniform strain within the region of cell attachment and …
Investigation Of Electrical Defects Arising From Excessive Sidewall Force And Excessive Tensile Strain On Power Cables, Darren Mcconnon, Joseph Kearney, Tom Looby, James O'Shaughnessy
Investigation Of Electrical Defects Arising From Excessive Sidewall Force And Excessive Tensile Strain On Power Cables, Darren Mcconnon, Joseph Kearney, Tom Looby, James O'Shaughnessy
Conference papers
The study includes a comprehensive review of the existing literature and guidelines regarding the effects of sidewall force and tensile strain on power cables during installation. The most appropriate diagnostic test methods required to analyse these effects are also assessed. The results of tests and analysis of the existing literature are then combined in an attempt to determine a realistic basis for guidelines and recommendations relevant to cable installation forces.