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Nanoscale Enhancement Of Photosensitized Radionuclide Stimulated Therapy, Daniel Douglas Lane
Nanoscale Enhancement Of Photosensitized Radionuclide Stimulated Therapy, Daniel Douglas Lane
McKelvey School of Engineering Theses & Dissertations
Photodynamic therapy (PDT) provides efficient tumor killing through the generation of reactive oxygen species (ROS) from the optical excitation of a photosensitizer (PS). Furthermore, this mechanism is highly immune stimulating, providing systemic tumor immunity with a reduction in metastasis. However, these materials had previously been limited by their dependence upon external light sources, allowing treatment of only laser-accessible malignancy. With the recent development of photosensitized radiation stimulated therapy (PRaST) this depth dependence is broken through co-localization of radionuclides and semiconducting photosensitizers. This dissertation focuses on the enhancement of titanium dioxide (TiO2) based PRaST agents through understanding of TiO2 material parameters …