Engineering Mechanics Commons^™

Significance Of The Vehicle Front Design And Gait Postures On Traumatic Brain Injuries Sustained By Different Pedestrian Populations During Car-To-Pedestrian Collisions (Cpcs) - A Computational Approach, Thava Kalishwara Kumar Gunasekaran

Electronic Thesis and Dissertation Repository

With the increasing prevalence of traumatic brain injuries (TBIs) in road traffic accidents (RTAs), it was identified that the shape of the vehicle's front end and pedestrian postures prior to impact significantly influence pedestrian head injuries. However, the effect of vehicle front shape parameters and gait postures on TBIs sustained in car-to-pedestrian collisions (CPCs) has yet to be quantified. This study used a computational approach to analyze the effect of vehicle shape parameters and pedestrian gait postures on pedestrian TBI risks across a diverse pedestrian population with varying body sizes. Our findings indicate that vehicle shape parameter such as BLEH …

Influence Of Extracellular Matrix Stiffness And Topography On Neuronal Cell Behavior And Neurite Outgrowth, Mohan Yasodharababu

Graduate Theses and Dissertations

The focus of regeneration therapy for traumatic brain injuries and Alzheimer's disease is on the promotion and growth of neuronal cells. In vitro research attempts to improve this by modifying the stiffness and topography of the extracellular matrix (ECM). However, the limitations of in vitro experiments make it difficult to control the individual factors influencing neuronal cell growth. A computational model can be used to decouple individual factors and study them individually to gain a better understanding of the mechanics between the neuronal cell and ECM, which will aid in the design of in vitro experimental studies.

This study develops …