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Full-Text Articles in Engineering Mechanics
Influence Of Extracellular Matrix Stiffness And Topography On Neuronal Cell Behavior And Neurite Outgrowth, Mohan Yasodharababu
Influence Of Extracellular Matrix Stiffness And Topography On Neuronal Cell Behavior And Neurite Outgrowth, Mohan Yasodharababu
Graduate Theses and Dissertations
The focus of regeneration therapy for traumatic brain injuries and Alzheimer's disease is on the promotion and growth of neuronal cells. In vitro research attempts to improve this by modifying the stiffness and topography of the extracellular matrix (ECM). However, the limitations of in vitro experiments make it difficult to control the individual factors influencing neuronal cell growth. A computational model can be used to decouple individual factors and study them individually to gain a better understanding of the mechanics between the neuronal cell and ECM, which will aid in the design of in vitro experimental studies.
This study develops …
Multiscale Modeling Of Impact On Heterogeneous Viscoelastic Solids With Evolving Microcracks, Flavio V. Souza
Multiscale Modeling Of Impact On Heterogeneous Viscoelastic Solids With Evolving Microcracks, Flavio V. Souza
Department of Engineering Mechanics: Dissertations, Theses, and Student Research
Multiscale computational techniques play a major role in solving problems related to viscoelastic composite materials due to the complexities inherent to these materials. In the present work, a numerical procedure for multiscale modeling of impact on heterogeneous viscoelastic solids containing evolving microcracks is proposed in which the (global scale) homogenized viscoelastic incremental constitutive equations have the same form as the local scale viscoelastic incremental constitutive equations, but the homogenized tangent constitutive tensor and the homogenized incremental history dependent stress tensor depend on the amount of damage accumulated at the local scale. Furthermore, the developed technique allows the computation of the …