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Neuroprotective And Anti-Inflammatory Effects Of Rhus Coriaria Extract In A Mouse Model Of Ischemic Optic Neuropathy, Saba Khalilpour, Ghazaleh Behnammanesh, Fouad Suede, Mohammed O. Ezzat, Jayadhisan Muniandy, Yasser Tabana, Mohamed B. K. Ahamed, Ali Tamayol, Amin Malik Shah Majid, Enrico Sangiovanni, Mario Dell'agli, Aman Shah Majid

Department of Mechanical and Materials Engineering: Faculty Publications

Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC₅₀) for DPPH, ABTS and B-carotene were 6.79 ± 0.009 µg/mL, 10.94 ± 0.09 µg/mL, and 6.25 ± 0.06 µg/mL, respectively. Retinal ischemia was induced by optic nerve crush injury in albino Balb/c mice. The anti-inflammatory activity of ethanolic extract of R. coriaria (ERC) and linoleic acid (LA) on …