Engineering Science and Materials Commons^™

Chloride Incorporation Process In Ch3Nh3Pbi3-XClX Perovskites Via Nanoscale Bandgap Maps, Jungseok Chae, Qingfeng Dong, Jinsong Huang, Andrea Centrone

Department of Mechanical and Materials Engineering: Faculty Publications

CH₃NH₃PbI_3-xCl_x perovskites enable fabrication of highly efficient solar cells. Chloride ions benefit the morphology, carrier diffusion length and stability of perovskite films; however, whether those benefits stem from the presence of Cl⁻ in the precursor solution or from their incorporation in annealed films is debated. In this work, the photothermal induced resonance (PTIR), an in situ technique with nanoscale resolution, is leveraged to measure the bandgap of CH₃NH₃PbI_3-xCl_x films obtained by a multicycle coating process that produces high efficiency (≈16 %) solar cells. Because chloride …

Inducing Persistent Flow Disturbances Accelerates Atherogenesis And Promotes Thin Cap Fibroatheroma Development In D374y-Pcsk9 Hypercholesterolemic Minipigs, Ryan M. Pedrigi, Christian Bo Poulsen, Vikram V. Mehta, Niels Ramsing Holm, Nilesh Pareek, Anouk L. Post, Ismail Dogu Kilic, Winston A.S. Banya, Gianni Dall'ara, Alessio Mattesini, Martin M. Bjorklund, Niels P. Andersen, Anna K. Grondal, Enrico Petretto, Nicolas Foin, Justin E. Davies, Carlo Di Mario, Jacob Fog Bentzon, Hans Erik Botker, Erling Falk, Rob Krams, Ranil De Silva

Department of Mechanical and Materials Engineering: Faculty Publications

Background—Although disturbed flow is thought to play a central role in the development of advanced coronary atherosclerotic plaques, no causal relationship has been established. We evaluated whether inducing disturbed flow would cause the development of advanced coronary plaques, including thin cap fibroatheroma (TCFA).

Methods and Results—D374Y-PCSK9 hypercholesterolemic minipigs (N=5) were instrumented with an intracoronary shear-modifying stent (SMS). Frequency-domain optical coherence tomography was obtained at baseline, immediately post-stent, 19, and 34 weeks and used to compute shear stress metrics of disturbed flow. At 34 weeks, plaque type was assessed within serially-collected histological sections and co-registered to …

Mammalian Synthetic Biology: Emerging Medical Applications, Zoltan Kis, Hugo Sant'ann Pereira, Takayuki Homma, Ryan M. Pedrigi, Rob Krams

Department of Mechanical and Materials Engineering: Faculty Publications

In this review, we discuss new emerging medical applications of the rapidly evolving field of mammalian synthetic biology.We start with simple mammalian synthetic biological components and move towards more complex and therapy-oriented gene circuits. A comprehensive list of ON–OFF switches, categorized into transcriptional, post-transcriptional, translational and posttranslational, is presented in the first sections. Subsequently, Boolean logic gates, synthetic mammalian oscillators and toggle switches will be described. Several synthetic gene networks are further reviewed in the medical applications section, including cancer therapy gene circuits, immuno-regulatory networks, among others. The final sections focus on the applicability of synthetic gene networks to drug …

Influence Of Spatial Variations Of Railroad Track Stiffness And Material Inclusions On Fatigue Life, Celestin Nkundineza

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Railroad transportation is very important for economic growth and effective maintenance is one critical factor for its economic sustainability. The high repetitive forces from a moving railcar induce cyclic stresses that lead to rail bending and potential deterioration due to fatigue crack initiation and propagation. Previous research for prediction of fatigue life has been done under the assumptions of a uniform track bed and a homogeneous rail. However the spatial variation of the track stiffness is expected to increase the maximum stresses in the rail and, therefore, accelerate the fatigue process. The research described in this dissertation is focused on …