Electrical and Electronics Commons^™

Quantitative Optical Imaging Of Metabolic And Structural Biomarkers In Rodent Injury Models, Shima Mehrvar

Theses and Dissertations

The assessment of organ metabolic function using optical imaging techniques is an overgrowing field of disease diagnosis. The broad research objective of my PhD thesis is to detect quantitative biomarkers by developing and applying optical imaging and image processing tools to animal models of human diseases. To achieve this goal, I have designed and implemented an optical imaging instrument called in vivo fluorescence imager to study wound healing progress. I have also developed a 3-dimensional (3D) vascular segmentation technique that uses intrinsic fluorescence images of whole organs.

Intrinsic fluorophores (autofluorescence signals) provide information about the status of cellular bioenergetics in …

Multi-Tap Extended Kalman Filter For A Periodic Waveform With Uncertain Frequency And Waveform Shape, And Data Dropouts, Justin Saboury

Theses and Dissertations

Gait analysis presents the challenge of detecting a periodic waveform in the presence of time varying frequency, amplitude, DC offset, and waveform shape, with acquisition gaps from partial occlusions. The combination of all of these components presents a formidable challenge. The Extended Kalman Filter for this system model has six states, which makes it weakly identifiable within the standard Extended Kalman Filter network. In this work, a novel robust Extended Kalman Filter-based approach is presented and evaluated for clinical use in gait analysis. The novel aspect of the proposed method is that at each sample, the present and several past …

Novel Non-Invasive Technology For The Detection Of Thin Biofilm In Piping Systems (Phase - 1), Sachin Davis

Theses and Dissertations

Biofilms are formed when a group of cells of microorganisms stick to each other and often on a surface. The development of biofilm has been a major issue in many fields (medical field, food, chemical, and water industry are a few such fields). In the medical field alone, biofilm infections have reportedly cost over five billion USD in additional healthcare expenses. The food industry usually halts the operation of its plant eight hours, every day to ensure that their equipment and transportation channels are clean and free from any biofilm presence. Similarly, the water and chemical industry need to ensure …

Novel Non-Invasive Technology For The Detection Of Thin Biofilm In Piping Systems (Phase - 1), Sachin Davis

Theses and Dissertations

Biofilms are formed when a group of cells of microorganisms stick to each other and often on a surface. The development of biofilm has been a major issue in many fields (medical field, food, chemical, and water industry are a few such fields). In the medical field alone, biofilm infections have reportedly cost over five billion USD in additional healthcare expenses. The food industry usually halts the operation of its plant eight hours, every day to ensure that their equipment and transportation channels are clean and free from any biofilm presence. Similarly, the water and chemical industry need to ensure …

Adaptation Of Moiré Phase Tracking To A Mobile Device For Field 3d Data Collections, Amar Nikhanj

Theses and Dissertations

The accelerating technologies of mobiles devices such as tablets and phones provide an ability to

perform high intensity calculations all while obtaining precise data with increasingly more accurate

sensors. Image metrology and 3D motion tracking can take advantage of these improvements as

they require both significant processing power and camera controls not seen in mobile devices until

very recently. This thesis discusses the development of 3D motion tracking using Google Nexus

tablets and applying the technology to the Rapid Upper Limb Assessment (RULA) to demonstrate

the technology’s application to field measurements. RULA analysis determines the stress placed on

a human …

An Optogenetic Brain-Machine Interface For Spatiotemporal Neuromodulation, Ryan Andrew Baumgartner

Theses and Dissertations

Direct neural stimulation has recently become a standard therapy for neurological disorders such as Parkinson's Disease, Essential Tremors, and Dystonia. Currently, deep brain electro-stimulation and neuro-pharmaceutical treatments are the dominant therapeutic options available to the public. As our understanding of brain function and neurological diseases improves, we are able to develop more advanced neuromodulation techniques. These methods could become viable treatment solutions for treating brain dysfunction. Optogenetics, first introduced by a research team led by Karl Deisseroth at Stanford University, has proved to be a versatile technique with remarkable potential to be used in treatments for brain disorders, dysfunction, and …