Controls and Control Theory Commons^™

Adaptive Personalized Drug Delivery Method For Warfarin And Anemia Management: Modeling And Control., Affan Affan

Electronic Theses and Dissertations

Personalized precision medicine aims to develop the appropriate treatments for suitable patients at the right time to obtain optimal results. Personalized medicine is challenging due to inter- and intra-patient variability, narrow therapeutic window, the effect of other medications, comorbidity (more than one disease at a time), nonlinear patient dynamics, and time-varying patient dose response characteristics which include bleeding (internal and external). This research aims to develop a framework for an adaptive personalized modeling and control method with minimum clinical patient specific dose response data for optimal drug dosing. The proposed methodology is applied to anemia and warfarin management. It is …

Power System Dynamic Control And Performance Improvement Based On Reinforcement Learning, Wei Gao

Electronic Theses and Dissertations

This dissertation investigates the feasibility and effectiveness of using Reinforcement Learning (RL) techniques for power system dynamic control, particularly voltage and frequency control. The conventional control strategies used in power systems are complex and time-consuming due to the complicated high-order nonlinearities of the system. RL, which is a type of neural network-based technique, has shown promise in solving these complex problems by fitting any nonlinear system with the proper network structure.

The proposed RL algorithm, called Guided Surrogate Gradient-based Evolution Strategy (GSES) determines the weights of the policy (which generates the action for our control reference signal) without back-propagation process …

Intelligent Learning Control System Design Based On Adaptive Dynamic Programming, Naresh Malla

Electronic Theses and Dissertations

Adaptive dynamic programming (ADP) controller is a powerful neural network based control technique that has been investigated, designed, and tested in a wide range of applications for solving optimal control problems in complex systems. The performance of ADP controller is usually obtained by long training periods because the data usage efficiency is low as it discards the samples once used. Experience replay is a powerful technique showing potential to accelerate the training process of learning and control. However, its existing design can not be directly used for model-free ADP design, because it focuses on the forward temporal difference (TD) information …