Computational Engineering Commons^™

Development Of A Computational Model To Investigate Pathways And The Effects Of Treatment In Fanconi Anemia, Sabrina Kellett

Biological Sciences Undergraduate Honors Theses

Fanconi Anemia (FA) is a rare type of anemia that is not easily studied and can have very detrimental effects. This disease compromises the bone marrow, resulting in decreased hemopoiesis. Symptoms of FA also include abnormalities in the brain and spinal cord, incorrect formation of the kidneys, abnormal formation of the heart and lungs, and a dramatically increased risk of developing cancer. FA can be caused by various mutations in any of the 22 genes that encode for proteins involved in what is called the FA DNA repair pathway. In healthy individuals, this pathway specifically repairs interstrand cross-links (ICLs) recognized …

Computational Decision Support For The Covid-19 Healthcare Coalition, Andreas Tolk, Christopher Glazner, Joseph Ungerleider

VMASC Publications

In the early months of 2020, the SARS-CoV-2 Coronavirus took the world by surprise, resulting in the COVID-19 pandemic that has caused significant loss of lives and challenged the sustainability of our health care systems. In mid-March, it became obvious that government and communities had to react immediately. Under the lead of the Mayo Clinic and The MITRE Corporation, the COVID-19 Healthcare Coalition (C19HCC) was established as a coordinated public-interest, private-sector response. The coalition brought healthcare organizations, technology firms, nonprofits, academia, and startups to support supply chains, inform coordinated social policies, and provide data-driven insights to protect people and preserve …

Multiscale Modeling Of Carbon Fibers/Graphene Nanoplatelets/Epoxy Hybrid Composites For Aerospace Applications, Hashim Al Mahmud

Dissertations, Master's Theses and Master's Reports

Significant research effort has been dedicated for decades to improve the mechanical properties of aerospace polymer-based composite materials. Lightweight epoxy-based composite materials have increasingly replaced the comparatively heavy and expensive metal alloys used in aeronautical and aerospace structural components. In particular, carbon fibers (CF)/graphene nanoplatelets (GNP)/epoxy hybrid composites can be used for this purpose owing to their high specific stiffness and strength. Therefore, this work has been completed to design, predict, and optimize the effective mechanical properties of CF/GNP/epoxy composite materials at different length scales using a multiscale modeling approach. The work-flow of modeling involves a first step of using …

Modelling Of Convective Heat Transfer In Porous Media, Jeremy Vu

Electronic Thesis and Dissertation Repository

This thesis details the process taken for the computational modelling of convective heat transfer in porous media. An in-house porous continuum model is modified to improve the prediction of heat transfer which is obtained when forcing fluid through porous blocks heated from one side. The results are compared to those obtained from CFD simulations performed using commercial software. Results indicated that a modification to conductivity the solid phase of the porous material must be included due to the tortuosity, or the complexity of the solid structure. Previously the tortuosity was not considered when calculating the effective solid phase conductivity.The implementation …

A Multiscale Model For Damage Progression And Detection In Piezo/Pyroelectric Composite Laminates, Yehia Bahei-El-Din, Amany Micheal

Centre for Advanced Materials

Assessment of damage initiation and progression in composite structures reinforced with electrically active filaments is modelled in a multiscale analysis. The analysis developed is a two-tier, interactive analysis, which involves two length scales; macroscopic, and microscopic. The proposed multiscale analysis provides seamless integration of the mechanics at the two length scales, including piezoelectric and pyroelectric coupling effects and damage under overall thermomechanical loads and an electric field applied to electroactive fibers. The macromechanical analysis is performed for multidirectional, fibrous laminates using the lamination theory, including bending, and the micromechanical analysis is performed using a two-phase model and a periodic array …

Developing An Application For Evolutionary Search For Computational Models Of Cellular Development, Nicolas Scott Cornia

Boise State University Theses and Dissertations

VPEvolve is a free and open source application that utilizes a Visual Programming Environment (VPE) for the setup of the Genetic Algorithm (GA), for optimization of computational models. Specifically, the User Interface uses connected glyphs to represent the genetic operators of mutation, reproduction, fitness and selection. These glyphs give the user an intuitive way to set the parameters for the GA, and better visualization of the population's flow through these operators.

VPEvolve is currently being developed alongside research being done in Biocomputing to create models of cellular regeneration based on the regenerative properties of Planaria or flatworms. Since these models …