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Department of Chemical and Biomolecular Engineering: Patents

1996

Transgenic mammals

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Expression Of Human Protein C In Mammary Tissue Of Transgenic Mammals , William H. Velander Dec 1996

Expression Of Human Protein C In Mammary Tissue Of Transgenic Mammals , William H. Velander

Department of Chemical and Biomolecular Engineering: Patents

Recombinant protein C characterized by a high percentage of active protein can be obtained in the milk of transgenic mammals that incorporate DNAs according to the present invention. Transgenic mammals of the present invention are produced by introducing into developing embryos DNA that encodes protein C, such that the DNA is stably incorporated in the DNA of germ line cells of the mature mammals and inherited in normal, mendelian fashion.