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Full-Text Articles in Biomaterials
Investigating Virus Clearance Via Ph Inactivation During Biomanufacturing, Wenbo Xu
Investigating Virus Clearance Via Ph Inactivation During Biomanufacturing, Wenbo Xu
Biomedical Engineering Undergraduate Honors Theses
In the processing of biopharmaceuticals, viral clearance and viral safety are important for the development of monoclonal antibodies. Murine xenotropic leukemia virus (XMuLV) is one of the retroviruses, recommended by Food and Drug Administration (FDA) as a model virus for viral clearance via inactivation from therapeutics derived from Chinese hamster ovary cells (CHO). A robust and effective method was investigated to clear or inactivate endogenous viruses by low pH inactivation. The effects of different conductivity and inactivated time on XMuLV clearance was determined. Acetate buffer was prepared with different conductivity, and 2% XMuLV was spiked into acetate buffer. XMuLV virus …
Effect Of Polymer Composition Of Injectable Hydrogels On Programmable Release Of Methylene Blue, Mary Brandecker
Effect Of Polymer Composition Of Injectable Hydrogels On Programmable Release Of Methylene Blue, Mary Brandecker
Biomedical Engineering Undergraduate Honors Theses
Temperature sensitive hydrogels have been used as injectable hydrogels because the polymer solutions can be liquid at room temperature and gel at body temperature. Injectable hydrogels have been used in biomedical applications to deliver drugs and other small molecules throughout the body. Methylene Blue was used as the drug in this study for its antioxidant and neuroprotective properties. PluronicⓇ F127 (PF127) is a copolymer consisting of repeating units of polyethylene oxide and polypropylene oxide in the form PEO-PPO-PEO. PF127 in solution is a temperature sensitive hydrogel that transitions to a gel at body temperature at specific polymer compositions. A standard …
Design Of Microporous Membranes For The Development Of Brain-On-Chip Devices, Andre Figueroa Milla
Design Of Microporous Membranes For The Development Of Brain-On-Chip Devices, Andre Figueroa Milla
Biomedical Engineering Undergraduate Honors Theses
Traumatic brain injuries (TBIs) are a major global health concern that have an economic impact of $60 billion in the United States in related costs annually. Developing drugs for TBI treatment is an approach that currently faces limitations involving the permeability of the blood-brain barrier (BBB). The BBB naturally limits molecules from reaching the brain as a protective mechanism against disease, acting as a barrier during drug delivery. Understanding the BBB mechanically and chemically following a TBI could potentially assist future studies to alleviate the symptoms and long-term effects of TBI by pharmaceuticals. The Mechanobiology and Soft Materials Laboratory (MSML) …