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Full-Text Articles in Biomaterials
Chitosan As An Antiviral, Tayler Pauls
Chitosan As An Antiviral, Tayler Pauls
Biomedical Engineering Undergraduate Honors Theses
There is no broad-based antiviral medication available today; there are specific antivirals, for example, the antiretroviral for HIV. However, these specific antivirals are not available in each country and can be problematic for specific patients. Chitosan is proposed as a possible broad-based antiviral, which has already demonstrated antibacterial properties, antiviral properties in plants, is used for wound healing and as a hydrogel among other medical applications. The methods used are transfection of NIH-3T3 cells with GFP-adenovirus with 0.1%, 0.5%, and 1% chitosan added to virus prior to transfection. Fluorescence microscopy and flow cytometry data has validated that the use of …
Investigating The Mechanical Behaviors Of Organic/Inorganic Composite Bone Scaffolds, Parker Davidson
Investigating The Mechanical Behaviors Of Organic/Inorganic Composite Bone Scaffolds, Parker Davidson
Biomedical Engineering Undergraduate Honors Theses
The regeneration of bone over a large area cannot occur without a structure for the bone cells to bind and divide. The use of an organic/inorganic composite bone scaffold appears to be a promising alternative to the current clinical standard of bone grafting. Bone grafting is very limited, in that the size and shape of the area are hard to replicate and the use of donor tissue can trigger an immunologic response resulting in rejection of the bone tissue. This study experimented with composite bone scaffolds which can be made to fit the shape of the area in which bone …
Customization Of Titanate Nanofiber Bioscaffolds, Jared Hopkins
Customization Of Titanate Nanofiber Bioscaffolds, Jared Hopkins
Biomedical Engineering Undergraduate Honors Theses
In the field of orthopedic devices implant loosening is a major issue resulting in the majority of device failures. These failures result in the need for costly secondary procedures. To reduce device loosening an improved method of tissue anchoring is required. A previously studied titanate nanofiber bioscaffold has been shown to be safely implantable and to contribute to the differentiation of mesenchymal stem cells to osteocytes. Through the customization of both physical and chemical characteristics this titanate nanofiber bioscaffold was fabricated as a potential means to enhance tissue anchoring for use with orthopedic devices. This customization was enabled by acoustic …
Isolation Of Metallic Single-Walled Carbon Nanotubes For Electrically Conductive Tissue Engineering Scaffolds, Jakob Hockman
Isolation Of Metallic Single-Walled Carbon Nanotubes For Electrically Conductive Tissue Engineering Scaffolds, Jakob Hockman
Biomedical Engineering Undergraduate Honors Theses
Metallic single-walled carbon nanotubes (m-SWNTs) were separated from pristine SWNTs using affinity chromatography for use in electrically conductive tissue engineering scaffolds. Approximately one third of SWNTs have metallic properties. Separations were achieved using a protocol modified from Liu & coworkers (2011) in order to improve the method for cell culture environments. Samples enriched in m-SWNTs were isolated and characterized. However, challenges still remain for the complete separation of m-SWNTs from their semiconducting counterpart (s-SWNTs) using this protocol. Approaches to improve separation and reduce the difficulties associated with processing the nanotubes were suggested. One of the ultimate destinations of these nanotubes …