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Full-Text Articles in Biomaterials
Developing Vascular Graft From Adipose-Derived Stem Cells, Ashley C. Apil
Developing Vascular Graft From Adipose-Derived Stem Cells, Ashley C. Apil
Research Opportunities for Engineering Undergraduates (ROEU) Program 2017-18
This project aims to differentiate adipose-derived stem cells into fibroblasts through the addition of platelet-derived growth factor (PDGF) into the culture media. Differentiation protocol will be optimized, then successful differentiation will be verified through PCR analysis. The ASC-fibroblasts will then be seeded into a ring construct as outlined by the protocol by Lam et al. The ring constructs will be tensile tested and analyzed through histology to characterize their strength and cellularity.
The Effect Of Tgfβ-1 On Adipose-Derived Stem Cell (Asc) Ring Constructs, Ashley C. Apil
The Effect Of Tgfβ-1 On Adipose-Derived Stem Cell (Asc) Ring Constructs, Ashley C. Apil
Research Opportunities for Engineering Undergraduates (ROEU) Program 2016-17
Adipose-derived Stem Cells (ASC’s) provide an optimal source for potentially graft replacing, tissue-engineered vessel constructs due to their ease of extraction and ability to be patient-specific. In order to make ASC ring constructs a more viable replacement for grafts, they need to have mechanical properties similar to native arteries, which is largely influenced by the extracellular matrix protein collagen. TGFβ-1 is known to stimulate collagen production in ASC’s, so this study explores the effect that TGFβ-1 has on the resulting thickness and tensile strength of ASC ring constructs.