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Articles 1 - 10 of 10
Full-Text Articles in Biomaterials
A Survey Of Stainless Steel In Medical And Surgical Application, Noah Slack, Clint Balch
A Survey Of Stainless Steel In Medical And Surgical Application, Noah Slack, Clint Balch
ME 4133/6133 Mechanical Metallurgy
Stainless steels can be separated into four families based on the microstructure of the material: Austenitic, Ferritic, Martensitic, and Duplex. Each family provides a specific set of advantages and disadvantages, and material selection should be based on the specific application the material will be used for. For this study, the processing, microstructure, and performance of the four families of stainless steels will be compared in the context of medical device applications. The most important factors in medical device materials are biocompatibility, surface properties, mechanical properties and life span/corrosion resistance. This study will focus on medical devices that will be permanently …
Poly(2-Hydroxyethyl Methacrylate) Hydrogels For Contact Lens Applications–A Review, Kushendarsyah Saptaji, Nurlaely Rohmatul Iza, Sinta Widianingrum, Vania Katherine Mulia, Iwan Setiawan
Poly(2-Hydroxyethyl Methacrylate) Hydrogels For Contact Lens Applications–A Review, Kushendarsyah Saptaji, Nurlaely Rohmatul Iza, Sinta Widianingrum, Vania Katherine Mulia, Iwan Setiawan
Makara Journal of Science
The emerging technology in biomedical engineering requires biocompatible materials, which are also referred to as biomaterials. For a material to be considered biocompatible, it should not interact with human tissues in a harmful way, and vice versa. Various properties of biocompatible materials, such as mechanical and optical properties, have to be considered for different biomedical applications. One of the most popular applications of biomaterials is for contact lenses. Hydrogels, specifically poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels, are among the most popular ones in ophthalmologic applications, especially in soft contact lenses. This paper reviews the use of PHEMA hydrogels as one of the …
Layered Double Hydroxide-Based Nanocomposite Scaffolds In Tissue Engineering Applications, Burcin Izbudak, Berivan Cecen, Ingrid Anaya, Amir K. Miri, Ayca Bal-Ozturk, Erdal Karaoz
Layered Double Hydroxide-Based Nanocomposite Scaffolds In Tissue Engineering Applications, Burcin Izbudak, Berivan Cecen, Ingrid Anaya, Amir K. Miri, Ayca Bal-Ozturk, Erdal Karaoz
Henry M. Rowan College of Engineering Faculty Scholarship
Layered double hydroxides (LDHs), when incorporated into biomaterials, provide a tunable composition, controllable particle size, anion exchange capacity, pH-sensitive solubility, high-drug loading efficiency, efficient gene and drug delivery, controlled release and effective intracellular uptake, natural biodegradability in an acidic medium, and negligible toxicity. In this review, we study potential applications of LDH-based nanocomposite scaffolds for tissue engineering. We address how LDHs provide new solutions for nanostructure stability and enhance in vivo studies' success.
Biomaterial For Cervical Intervertebral Disc Prosthesis, Helium Mak
Biomaterial For Cervical Intervertebral Disc Prosthesis, Helium Mak
Electronic Thesis and Dissertation Repository
Recent long-term follow-up studies have shown that the cervical disc arthroplasty treatment have potentials in developing surrounding heterotopic ossification (HO). While its cause requires further investigation, this thesis has hypothesized that it may be the result of the continual remodeling of the injured vertebrae caused by the prostheses with smaller footprints introducing abnormal stresses. The research objective of this thesis is to develop a new prosthesis material that can be molded into any form conforming to the size and shape of the end-plates of the affected patient vertebrae. For prototype development, a composite material consisting of 10wt% polyvinyl alcohol cryogel …
A Single Cell Pair Mechanical Interrogation Platform To Study Cell-Cell Adhesion Mechanics, Amir Monemianesfahani
A Single Cell Pair Mechanical Interrogation Platform To Study Cell-Cell Adhesion Mechanics, Amir Monemianesfahani
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
Cell-cell adhesion complexes are macromolecular adhesive organelles that integrate cells into tissues. Perturbations of the cell-cell adhesion structure or relatedmechanotransduction pathways lead to pathological conditions such as skin and heart diseases, arthritis, and cancer. Mechanical stretching has been used to stimulate the mechanotransduction process originating from the cell-cell adhesion and cell-extracellular matrix (ECM) complexes. The current techniques, however, have limitations on their ability to measure the cell-cell adhesion force directly and quantitatively. These methods use a monolayer of cells, which makes it impossible to quantify the forces within a single cell-cell adhesion complex. Other methods using single cells or cell …
Survival And Proliferation Under Severely Hypoxic Microenvironments Using Cell-Laden Oxygenating Hydrogels, Shabir Hassan, Berivan Cecen, Ramon Peña-Garcia, Fernanda R. Marciano, Amir K. Miri, Ali Fattahi, Christina Karavasili, Shikha Sebastian, Hamza Zaidi, Anderson O. Lobo
Survival And Proliferation Under Severely Hypoxic Microenvironments Using Cell-Laden Oxygenating Hydrogels, Shabir Hassan, Berivan Cecen, Ramon Peña-Garcia, Fernanda R. Marciano, Amir K. Miri, Ali Fattahi, Christina Karavasili, Shikha Sebastian, Hamza Zaidi, Anderson O. Lobo
Henry M. Rowan College of Engineering Faculty Scholarship
Different strategies have been employed to provide adequate nutrients for engineered living tissues. These have mainly revolved around providing oxygen to alleviate the effects of chronic hypoxia or anoxia that result in necrosis or weak neovascularization, leading to failure of artificial tissue implants and hence poor clinical outcome. While different biomaterials have been used as oxygen generators for in vitro as well as in vivo applications, certain problems have hampered their wide application. Among these are the generation and the rate at which oxygen is produced together with the production of the reaction intermediates in the form of reactive oxygen …
Design And Control Of A Peristaltic Pump To Simulate Left Atrial Pressure In A Conductive Silicone Model, Jeremy Collins
Design And Control Of A Peristaltic Pump To Simulate Left Atrial Pressure In A Conductive Silicone Model, Jeremy Collins
Mechanical Engineering Undergraduate Honors Theses
According to the CDC, atrial fibrillation is responsible for more than 454,000 hospitalizations and approximately 158,000 deaths per year. A common treatment for atrial fibrillation is catheter ablation, a process in which a long flexible tube is guided through the femoral artery and to the source of arrhythmia in the heart, where it measures the electrical potential at various locations and converts problematic heart tissue to scar tissue via ablation. This paper details the design and control of a low-cost ($400) peristaltic pump system using repetitive control to replicate blood pressure in the left atrium in a conductive silicone model …
Additive Manufacturing In Personalized Medicine: Patient-Customized Solid Dose Medicines, And Patient-Customized Wound Care Device, Amir Najarzadeh
Additive Manufacturing In Personalized Medicine: Patient-Customized Solid Dose Medicines, And Patient-Customized Wound Care Device, Amir Najarzadeh
Theses and Dissertations--Mechanical Engineering
Personalized Medicine - from a one-size fits all to a tailored approach is the future in pharmaceutical therapeutics and medical applications. The aim of this study is demonstrate additive manufacturing in two personalized medicine applications: 1. Patient- customized solid dose medicines, and 2. Patient-customized wound care device. The aim of the first application is to develop an inexpensive and accurate method to design and fabricate patient-customized tablets. Particularly this paper focuses on fabricating and dose controlling of patient-customized extended release prednisolone-poly(vinyle alcohole) PVA. Dry-Blending, Wet Granulation, Extrusion, Spherionization, Hot melt extrusion (HME) was adopted to produce drug loaded prednisolone-PVA filaments …
Development Of Light Actuated Chemical Delivery Platform On A 2-D Array Of Micropore Structure, Hojjat Rostami Azmand, Hojjat Rostami Azmand
Development Of Light Actuated Chemical Delivery Platform On A 2-D Array Of Micropore Structure, Hojjat Rostami Azmand, Hojjat Rostami Azmand
Dissertations and Theses
Localized chemical delivery plays an essential role in the fundamental information transfers within biological systems. Thus, the ability to mimic the natural chemical signal modulation would provide significant contributions to understand the functional signaling pathway of biological cells and develop new prosthetic devices for neurological disorders. In this paper, we demonstrate a light-controlled hydrogel platform that can be used for localized chemical delivery in a high spatial resolution. By utilizing the photothermal behavior of graphene-hydrogel composites confined within micron-sized fluidic channels, patterned light illumination creates the parallel and independent actuation of chemical release in a group of fluidic ports. The …
Tailoring Texture, Microstructure, And Shape Memory Behavior Of Niti Alloys Fabricated By L-Pbf-Am, Sayed Ehsan Saghaian N.E.
Tailoring Texture, Microstructure, And Shape Memory Behavior Of Niti Alloys Fabricated By L-Pbf-Am, Sayed Ehsan Saghaian N.E.
Theses and Dissertations--Mechanical Engineering
Laser Powder Bed Fusion (L-PBF) is one of the most promising Additive Manufacturing (AM) methods to fabricate near net-shape metallic materials for a wide range of applications such as patient-specific medical devices, functionally graded materials, and complex structures. NiTi shape memory alloys (SMAs) are of great interest due to a combination of unique features, such as superelasticity, shape memory effect, high ductility, work output, corrosion resistance, and biocompatibility that could be employed in many applications in automotive, aerospace, and biomedical industries. Due to the difficulties with traditional machining and forming of NiTi components, the ability to fabricate complex parts, tailor …