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Full-Text Articles in Biological Engineering
Bio Circuits For Evolutionary Biotech, Camilo Toruno
Bio Circuits For Evolutionary Biotech, Camilo Toruno
ENGS 86 Independent Projects (AB Students)
The field of bioengineering has much promise for renewable chemical production, bioremediation, and of course medical applications. Developing new useful microorganisms is extremely time and capital intensive, typically taking 50 million USD and eight years. This is due in large part to the low throughput techniques that are characteristic of the field of metabolic engineering. Here we describe the modification of an existing synthetic biosensor to measure the pharmaceutical dopamine, and the use of a circuit simulator Cadence to predict improvements to the biosensor. This biosensor paired with directed evolution techniques could reach throughputs of 5 million cells per day …
Beyond Biobricks: Synthesizing Synergistic Biochemical Systems From The Bottom-Up, Mark A. Bedau
Beyond Biobricks: Synthesizing Synergistic Biochemical Systems From The Bottom-Up, Mark A. Bedau
Systems Science Friday Noon Seminar Series
Engineers who attempt to discover and optimize the behavior of complex biochemical systems face a dauntingly difficult task. This is especially true if the systems are governed by multiple qualitative and quantitative variables that have non-linear response functions and that interact synergistically. The synthetic biology community has responded to this difficulty by promoting the use of "standard biological parts" called "BioBricks", which are supposed to make biology into traditional engineering and enable engineers to "program living organisms in the same way a computer scientists can program a computer". But the BioBricks research program faces daunting hurdles, because the nonlinearity and …