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Experimental And Numerical Investigation Of Wire Waveguides For Therapeutic Ultrasound Angioplasty, Declan Noone (Thesis)

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Therapeutic ultrasound angioplasty is an emerging minimally invasive cardiovascular procedure for disrupting atherosclerotic lesions using small diameter wire waveguides. The lesions are damaged through a combination of direct ablation, pressure waves, cavitation and acoustic streaming caused by distal-tip displacements at ultrasonic frequencies. Numerical and experimental methods are used to investigate the outputs of the wire waveguides during ultrasonic activation. A commercially available generator and acoustic horn are used in combination with Nickel-Titanium (NiTi) wire waveguides in this study. A laser sensor is used to measure the frequency and amplitude output of the distal tip of the wire waveguide, and this …