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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Effect Of Cell-Surface Interactions On Monocyte-Derived Immunotherapy Products, Corinne Hoesli
Effect Of Cell-Surface Interactions On Monocyte-Derived Immunotherapy Products, Corinne Hoesli
Cell Culture Engineering XV
Monocyte-based cellular therapy products have been approved by the FDA for immunotherapy applications. The transition from a research and preclinical setting to the clinic is typically associated with a shift open culture systems such as polystyrene flasks to closed cell culture systems. Closed systems such as fluoropolymer-based bags offer benefits from a handling and safety perspective. However, the interactions between cells and fluoropolymer surfaces may differ from polystyrene surfaces. Differences between the physicochemical properties of the materials may profoundly impact the type and conformations of the proteins adsorbing to the surfaces. In turn, differences in the protein adlayer formed on …
Engineering Nanocomposites For Antimicrobial Application, Binyu Yu
Engineering Nanocomposites For Antimicrobial Application, Binyu Yu
Electronic Thesis and Dissertation Repository
In this thesis, active and passive antimicrobial methods have been applied to fabricate antifouling surfaces. In the first study, we reported the synthesis and characterization of neat TiO2 and Ag-TiO2 composite nanofilms prepared on silicon wafer by sol-gel method. The synthesized Ag-TiO2 thin films showed enhanced bactericidal activities compared to the neat TiO2 nanofilm both in the dark and under UV illumination. The advantage of Ag-TiO2 nano-composites is to expand the nanomaterial’s antibacterial function to a broader range of working conditions. In the second study, we reported the synthesis, characterization and environmental application of nitrogen …
Probing The Mechanisms Of Platelet Adhesion To Adsorbed Plasma Proteins, Balakrishnan Sivaraman
Probing The Mechanisms Of Platelet Adhesion To Adsorbed Plasma Proteins, Balakrishnan Sivaraman
All Dissertations
Despite over three decades of research in blood-material interactions, the biomaterials field has been unsuccessful in developing a truly non-thrombogenic biomaterial. This is due to an incomplete understanding of the factors underlying biomaterial-associated thrombosis, especially the mechanisms mediating the interactions of platelets with the adsorbed plasma protein layer(s) on the implant surface. The work presented here is motivated by the primary goal of delineating these mechanisms, and understanding the platelet receptors involved, as well as the domains/amino acid sequences they bind to in the protein molecules.
It is critical to differentiate between the amount and the conformation of the adsorbed …
Development Of Experimental Methods To Assess Adsorption Free Energy For Peptide-Surface Interactions, Yang Wei
All Dissertations
Because of its governing role in cellular response to implants and substrates for biomedical applications, the understanding and control of protein adsorption to material surfaces has been one of the major topics of research in the field of biomaterials. Unfortunately, it has proven to be extremely difficult to quantitatively understand and control these types of interactions because of the complexities involved, and existing methods that have been developed and used to characterize protein-surface interactions have proved to be inadequate to provide the level of detail necessary to achieve this understanding. New, more fundamental methods, both experimental and computational, are needed …