Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Biomedical Engineering and Bioengineering
Optical Studies Of Oxidative Stress In Lung Tissue: Rodent Models, Reyhaneh Sepehr
Optical Studies Of Oxidative Stress In Lung Tissue: Rodent Models, Reyhaneh Sepehr
Theses and Dissertations
Objectives: There currently exists a need for reliable measurements of tissue metabolic state at cellular levels. The objective of this research was to study tools capable of evaluating cellular redox states in intact tissue. To meet this goal, three different instruments (cryoimager, fluorometer, and fluorescent microscope) were used to study the metabolism and functions of the mitochondria at different levels and regimes (cryo, ex vivo, in vivo and in vitro).
Introduction: Through optical monitoring of autofluorescent mitochondrial metabolic coenzymes, as well as exogenous fluorophores, the state of mitochondria can be probed in real time in many intact organs and in …
Optical Cryoimaging Of Celular Redox In Kidneys From Diabetic Mice, Sepideh Maleki
Optical Cryoimaging Of Celular Redox In Kidneys From Diabetic Mice, Sepideh Maleki
Theses and Dissertations
Diabetic Nephropathy (DN) is the major single cause of end stage renal diseases (ESRD) in the United States. Diabetes is the third leading fatal disorder after cancer and heart disease. It is affecting 8.3% of the residents of the United States, with a total healthcare cost of $174 billion/yr by 2010.
There currently exists a need for a sensitive and specific diagnosis for temporal detection of oxidative stress (OS) in cellular metabolic levels, which plays an early role in the development of DN. The objective of this research is to use a fluorescence optical imaging technique in order to delineate …