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Microsphere

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Full-Text Articles in Biomedical Engineering and Bioengineering

Colloid Fabrication For Biomedical Engineering Applications Through Droplet Microfluidics, Lewis I. Larsen Dec 2023

Colloid Fabrication For Biomedical Engineering Applications Through Droplet Microfluidics, Lewis I. Larsen

Biomedical Engineering ETDs

The goal of this work was to leverage soft colloid fabrication through droplet microfluidics to improve the biomedical fields of radiotracer microspheres for selective internal radiation therapy (SIRT) and 3D hydrogel tissue constructs for cell culture with future potential as a platform to study liver diseases and drug response. The importance of positron emission tomography (PET) imaging microspheres infused with positron-emitting radioisotopes such as Ga-68, Cu-64, and F-18 is that they accurately map tumor-to-liver uptake (TLR) ratio and lung shunting factor of hepatocellular carcinoma. These pretreatment radiotracers model the intravascular accumulation behavior of radioactive therapeutic Y-90 SIRT microspheres. Qualifying patients, …

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Peptoid-Based Microsphere Coatings For Biomaterial Applications, Jesse Leland Roberts May 2021

Peptoid-Based Microsphere Coatings For Biomaterial Applications, Jesse Leland Roberts

Graduate Theses and Dissertations

Peptoids are peptidomimetic oligomers that predominantly harness similarities to peptides for biomimetic functionality. The incorporation of chiral, aromatic side chains in the peptoid sequence allows for the formation of distinct secondary structures and self-assembly into supramolecular assemblies, including microspheres. Peptoid microspheres can be coated onto substrates for potential use in biosensor technologies, tissue engineering platforms, and drug-delivery systems. They have the potential for use in biomedical applications due to their resistance to proteolytic degradation and low immunogenicity. This dissertation focuses on the physical characteristics and robustness of the peptoid microsphere coatings in various physiological conditions, along with their ability to …

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Polystyrene Microsphere And 5-Fluorouracil Release From Custom Designed Wound Dressing Films, Maryam Mobed-Miremadi, Raki Komarla Nagendra, Sujana Lakshmi Ramachandruni, Jason James Rook, Mallika Keralapura, Michel Goedert Jan 2013

Polystyrene Microsphere And 5-Fluorouracil Release From Custom Designed Wound Dressing Films, Maryam Mobed-Miremadi, Raki Komarla Nagendra, Sujana Lakshmi Ramachandruni, Jason James Rook, Mallika Keralapura, Michel Goedert

Bioengineering

Custom-designed wound dressing films of chitosan and alginate have been prepared by a casting/solvent evaporation method for hydrophobic therapeutic agent encapsulation. In this parametric study, the propylene glycol (PG) and calcium chloride (CaCl2) concentrations were varied for chitosan and alginate films, respectively. Mechanical and chemical inter-related responses under observations included thickness (th), elasticity (E), tensile strength (TS), sorption ability (S%) and kinetics of in-vitro drug release, specifically in terms of membrane time to burst (tB) and duration of release (tR). As shown by results of a one tailed t-test significance testing at the 95% confidence interval (α = …

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