Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Biomedical Engineering and Bioengineering
A Left Ventricular Motion Phantom For Cardiac Magnetic Resonance Imaging, Mehmet Ersoy
A Left Ventricular Motion Phantom For Cardiac Magnetic Resonance Imaging, Mehmet Ersoy
ETD Archive
The mammalian left ventricle (LV) has two distinct motion patterns: wall thickening and rotation. The purpose of this study was to design and build a low-cost, non-ferromagnetic LV motion phantom, for use with cardiac magnetic resonance imaging (MRI), that is able to produce physiologically realistic LV wall thickening and rotation. Cardiac MRI is continuously expanding its range of techniques with new pulse sequences, including new tissue tagging techniques which allow intra-myocardial deformation to be visualized. An essential step in the development of new cardiac MRI techniques is validating their performance in the presence of motion. MRI-compatible dynamic motion phantoms are …
Evaluation Of Upper Motor Neuron Pathology In Amyotrophic Lateral Sclerosis By Mri;Towards Identifying Noninvasive Biomarkers Of The Disease, Venkateswaran Rajagopalan
Evaluation Of Upper Motor Neuron Pathology In Amyotrophic Lateral Sclerosis By Mri;Towards Identifying Noninvasive Biomarkers Of The Disease, Venkateswaran Rajagopalan
ETD Archive
Amyotrophic lateral sclerosis (ALS) is the commonest adult motor neuron disease (MND) which causes progressive muscle paralysis and death usually within 5 years of symptom onset. As a result, only ╠â30,000 individuals in the United States are afflicted at any one time even though 5,000 or more individuals are diagnosed yearly. The diagnosis of ALS requires evidence of degeneration in upper motor neurons (UMNs) in the brain and in lower motor neurons (LMNs) that exit the brainstem and spinal cord to innervate skeletal muscles. Diagnosis can be incorrect or delayed when disease is early or atypical because non-invasive objective tests …
Altered Cortico-Cortical Brain Connectivity During Muscle Fatigue, Zhiguo Jiang
Altered Cortico-Cortical Brain Connectivity During Muscle Fatigue, Zhiguo Jiang
ETD Archive
Traditional brain activation studies using neuroimaging such as functional magnetic imaging (fMRI) have shown that muscle fatigue at submaximal intensity level is associated with increased brain activity in various cortical regions from low- to high-order motor centers. However, how these areas might interact remain unclear since previous activation studies related to motor control could not reveal information of between-area interaction. This issue can be addressed by evaluating brain activation data using the framework of connectivity analysis. Three types of brain connectivity, functional connectivity (FC), effective connectivity (EC) and structural connectivity (SC) have been examined to investigate the effect of voluntary …
Imaging Of Tyramine-Substituted Hydrogels For Tissue Replacement, Ediuska V. Laurens
Imaging Of Tyramine-Substituted Hydrogels For Tissue Replacement, Ediuska V. Laurens
ETD Archive
Novel tyramine-based hyaluronan (HA) and collagen hydrogels have been developed in which cross-linking is accomplished via peroxidase-mediated dityramine linkages allowing direct cross-linking in vivo. These TB hydrogels possess advantageous physical properties, which include excellent biocompatibility and the ability to mimic the biological, structural and mechanical properties of normal, healthy tissues, including cartilage, and thus provide for synthetic, implantable biomaterials suitable for a wide range of tissue types. The efficacy of these TB-hydrogels has been previously tested in a number of clinically relevant animal models, which have evaluated their applicability for the repair/replacement of various tissues, including cartilage. Nevertheless, there exists …