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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Bone Tissue Quality Determination Of Mice Through A Novel Reference Point Indentation Technique, Matin Lendhey
Bone Tissue Quality Determination Of Mice Through A Novel Reference Point Indentation Technique, Matin Lendhey
Dissertations and Theses
"Bone strength deteriorates with age; which increases the susceptibility to fracture. Current clinical techniques for the estimation of bone strength are largely Bone Mineral Density (BMD) based. However, toughness, which is the ability to resist crack growth, plays a critical role in bones‟ fracture resistance. Traditionally, toughness measurements involve large samples, obviating their use clinically. Recent data suggest that a reference point indentation approach provides a novel, localized measure of toughness from whole bones. In the current research, we evaluated the sensitivity of this method to discriminate small known differences in fracture toughness that exist between inbred mouse strains with …
Effects Of Estrogen Loss On The Vascular Porosity In Rat Cortical Bone, Jessica D Levy
Effects Of Estrogen Loss On The Vascular Porosity In Rat Cortical Bone, Jessica D Levy
Dissertations and Theses
"Osteoporosis is a skeletal disease that currently affects 10 million Americans, and is characterized by low bone mass and increased skeletal fragility (National Osteoporosis Foundation, 2011). Estrogen loss, which begins during menopause, is the leading cause of osteoporosis in women. Recent research has focused on changes in cortical bone microporosity due to estrogen loss, which is important for bone health; load-induced interstitial fluid flow within the lacunar-canalicular porosity surrounding osteocytes is thought to play an important role in bone maintenance, while the vascular porosity provides a pressure relaxation mechanism for the fluid flow in the lacunar-canalicular porosity. Recent high-resolution micro-CT …