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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 30 of 53
Full-Text Articles in Biomedical Engineering and Bioengineering
Auto Adjustable Flow Regulator, Ethan Hemmerlin, Jack Dooley
Auto Adjustable Flow Regulator, Ethan Hemmerlin, Jack Dooley
Biomedical Engineering
The Auto-Adjustable Oxygen Flowmeter device is to be used in conjunction with an oxygen source or reservoir, as well as a low-flow nasal cannula apparatus. The device is applicable for patients requiring an oxygen flow rate of 0-6 L/min. Further, the device works to maintain a healthy blood-oxygen concentration of 90-94% for typical patients, as well as an 88-92% range for COPD patients who are chronic CO2 retainers. A reflective pulse oximeter will record the SpO2 concentration of the patient. The outputted SpO2 concentration will be transmitted to an internal processing PCB from which it will interact with the oxygen …
Engineering The Development Of Neuromuscular Circuitry On-Chip, Inès Khiyara
Engineering The Development Of Neuromuscular Circuitry On-Chip, Inès Khiyara
Electronic Theses and Dissertations
Neuromuscular development happens in a complex interconnected network of biochemical pathways. This complicated embryonic development follows a strong, functional, and precise neuromuscular network that has interested both scientists and engineers who seek to better understand neuromuscular diseases. These disorders can be inherited or acquired, and their severity and mortality can vary. Researchers first studied the neuromuscular network from an organismal perspective, and more recently from an embryological, cellular, molecular, biochemical, and genetic perspective. From these studies, the fundamental principles of motor neuron pathfinding to muscles are widely understood, but the molecular drivers of specific nerve-muscle pairing remain unknown. Although in …
The Influence Of Flow Mechanotransduction On Endothelial Cells In The Lymphatic Valve Sinus, Joshua Daniel Hall
The Influence Of Flow Mechanotransduction On Endothelial Cells In The Lymphatic Valve Sinus, Joshua Daniel Hall
Doctoral Dissertations
Fluid flow in the cardiovascular and lymphatic systems influences the phenotype of endothelial cells that line the interior to the vessel via mechanotransduction. Geometric features in a vessel such as curvature, bifurcation, and valves promote heterogeneous fluid flow profiles, inducing a heterogeneous endothelial phenotype within a vessel region. Certain flow conditions are associated with vascular dysfunction, and diseases such as atherosclerosis preferentially develop in areas of flow disturbance. Lymphatic vessels are highly analogous to blood vessels, although lymphatic flow characteristics and its effect on lymphatic endothelial cells (LECs) via mechanotransduction have been comparatively less examined. The most significant geometric features …
Manual Material Handling Lift-Assist System For Occupational Exoskeleton, Erik Goes, Daniel Guthrie, Trevor Ward
Manual Material Handling Lift-Assist System For Occupational Exoskeleton, Erik Goes, Daniel Guthrie, Trevor Ward
Honors Capstones
It is no secret that lifting heavy objects is one of the premier causes of workplace injury, and the modern worker needs help to remain healthy. Workers need something they always have with them that makes their work safer as well as easier; our solution is an active lift-assist exoskeleton. The proposed exoskeleton design includes a military backpack exoskeleton frame, on which two actuators pull cables attached to end effectors that the operator will be holding. This system can adjust to conform to a wide variety of operator sizes, without restricting any of their range of motion. This leads to …
Synthesis Of Monodisperse Nanoscintillators At High Temperatures For Biomedical Relevant Applications, Eric Zhang
Synthesis Of Monodisperse Nanoscintillators At High Temperatures For Biomedical Relevant Applications, Eric Zhang
All Dissertations
Luminescent sub-100 nm particulates continuously generate immense research interest in the biomedical field for imaging, theranostics, and optogenetics. Conventionally, upconversion nanoparticles or UV activated semiconductors are studied, however these materials are limited by biological barriers such as the skin which reduces the penetration depth of these excitation sources, tissue's auto- fluorescence, and toxicity. One approach to overcome these challenges is to use nanoscintillators (sub-100 nm materials that can generate visible light using high energy excitation sources such as x-rays) which can generate light locally to the human body. Numerous scintillators have been reported since the discovery of x-rays from the …
Insole Fall Prevention Device, Nick M. Hughes, Andrew M. Slaboda
Insole Fall Prevention Device, Nick M. Hughes, Andrew M. Slaboda
Biomedical Engineering
Falls among the aging population occur every single day, with 1 in every 5 resulting in some injury and 300,000 hospitalized every year with a hip fracture [1]. The most popular and effective way to mitigate these falls is through physical therapist intervention. However, with the increased popularity in telerehab, many patients at risk for falls cannot accurately convey their gait tendencies to their physical therapists from the comfort of their home or while not in direct contact with the PT. A device like an insole, implanted with force sensors, which measures different parts of a patient’s foot, could convey …
Medical Sound Simuvest, Luke Stanley, Daniel Woods, Megan Hines, Chris Cochran
Medical Sound Simuvest, Luke Stanley, Daniel Woods, Megan Hines, Chris Cochran
Chancellor’s Honors Program Projects
No abstract provided.
A Survey Of Stainless Steel In Medical And Surgical Application, Noah Slack, Clint Balch
A Survey Of Stainless Steel In Medical And Surgical Application, Noah Slack, Clint Balch
ME 4133/6133 Mechanical Metallurgy
Stainless steels can be separated into four families based on the microstructure of the material: Austenitic, Ferritic, Martensitic, and Duplex. Each family provides a specific set of advantages and disadvantages, and material selection should be based on the specific application the material will be used for. For this study, the processing, microstructure, and performance of the four families of stainless steels will be compared in the context of medical device applications. The most important factors in medical device materials are biocompatibility, surface properties, mechanical properties and life span/corrosion resistance. This study will focus on medical devices that will be permanently …
Immunomodulatory Biomaterials For Cancer Immunotherapy, Larry Donnell Stokes Jr
Immunomodulatory Biomaterials For Cancer Immunotherapy, Larry Donnell Stokes Jr
Honors Theses
Cancer immunotherapy has become an effective treatment in the toolbox of oncologists. Immunotherapy offers a less toxic alternative to standard cancer treatments such as chemotherapy and can have prolonged curative effects to decrease cancer recurrence. Today, many drugs and biological agents have been developed that target the immune system and elicit an antitumor/cancer response. These agents are known collectively as cancer immunotherapies. While immunotherapies have radically improved treatment outcomes for many cancer patients, there are drawbacks to using these treatments. Immunotherapy treatments have poor clinical responses in patients with tumors that lack immunogenicity. Some of the treatments also pose a …
A Method For Orientation Of Cellulose Nano Fibers For Addition Of Biological Nanoparticles And Tissue Integration, Joshua Hamilton
A Method For Orientation Of Cellulose Nano Fibers For Addition Of Biological Nanoparticles And Tissue Integration, Joshua Hamilton
Honors College
The University of Maine is one of the world’s leading producers of cellulose nanofibers (CNF). This material has the power to revitalize the Maine paper industry. This has led to an abundance of labs on campus researching applications for the material. Active research activities at the University of Maine include industrial applications such as filtration, biodegradable packaging, building materials and niche health care applications. Niche health care applications include wicking pads for point of care diagnostics and tunable biomaterials ranging from dressings to implantable bone-like materials. Medical applications require an analysis of the biocompatibility of CNF.CNF is biocompatible in general: …
Smart Motor Syringe System, Conard Chan, Jenny Chiao
Smart Motor Syringe System, Conard Chan, Jenny Chiao
Electrical Engineering
Syringe pumps are widely used in many research applications especially in the applications that need precise control. Today most medical research utilizes syringes to control the fluid being pumped to the experiment objects. In most cases microscopic or nano-scopic motion control is required to acquire optimal results, such application includes purification of DNA/RNA from contaminants[1]. The high precision required to control the syringe pump makes it difficult to perform manually. This paper focuses on the design of an intelligent syringe pump motor control system to achieve reliable and precise control for biomedical experiments. This project improves medical research quality with …
In The Pursuit Of Assistance: A Team's Desire To Not Let A Congenital Amputation Get In A Young Boy's Way, Carl Russell Iii, Gavin Loucks, Kirsten Wozniak
In The Pursuit Of Assistance: A Team's Desire To Not Let A Congenital Amputation Get In A Young Boy's Way, Carl Russell Iii, Gavin Loucks, Kirsten Wozniak
Purdue Journal of Service-Learning and International Engagement
EPICS is a service-learning design program run through Purdue University. It strives to teach students design skills through providing for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. BME (Biomedical Engineering) is a team within EPICS that strives to serve community partners through biomedical applications. William Sevick is an elementary school student with a congenital arm amputation. William and his family have been working with the BME team for the past three years designing assistive devices with the purpose of improving his actions in daily life such as eating, playing games, and riding his bike.
An Improved Method For Hospital Acquired Pressure Ulcer (Hapu) Prevention, Megan Morrissey, Jillian Yeager, Julia Beekman
An Improved Method For Hospital Acquired Pressure Ulcer (Hapu) Prevention, Megan Morrissey, Jillian Yeager, Julia Beekman
Honors Theses
Hospital acquired pressure ulcers (HAPUs), also called bedsores, are damage to the skin and/or underlying tissue caused by prolonged pressure on the bony areas of the body, with around 20% of pressure ulcers occurring in the heel region. Currently, the most common practice for HAPU prevention is arbitrary manual repositioning of patients by nurses every 1-2 hours. The goal of our project was to address HAPUs in the heel region of low mobility patients through an ulceration risk sensing system. Our team has created a wearable ulceration risk assessment system that combines individual patient risk data with real time pressure …
Bionic Hand Team, Christopher T. Rossiter, David J. Bogacz, Carly J. Ulrich
Bionic Hand Team, Christopher T. Rossiter, David J. Bogacz, Carly J. Ulrich
Scholars Symposium
The project goal is to design a low cost prosthetic hand controlled by a PIC18F25K22 microcontroller that will allow the user to perform simple tasks that require a greater dexterity than what a mechanical prosthetic can deliver. The digits of the prosthetic will be contracted or relaxed using electromyographic signals measured by electrodes on a single muscle group. Grip settings, which define the open and closed position for each digit, are used for the control of the hand. This allows common actions, such as grabbing a door handle or pencil, to be accomplished with readings from one muscle group instead …
Lower Extremity Exoskeleton, Kelly Haslett, Jacalyn Everhart
Lower Extremity Exoskeleton, Kelly Haslett, Jacalyn Everhart
Williams Honors College, Honors Research Projects
Develop a lower extremity device that provides assistance, support, and gait correction for children with cerebral palsy who display crouch gait as a symptom. The device will be designed for children ages 7-12. The device will be adjustable to accommodate varying levels of gait irregularity, weakness and human growth. The device would assist walking and stair climbing by providing bilateral support at hips, knees and ankle joints. The device will be designed for ease of donning and doffing. Battery, drive and control electronics will be designed to reside in a minimalistic backpack (outside the scope of this project).
Adaptive Bike Pedals, Norman Hansen, Robert Csaky
Adaptive Bike Pedals, Norman Hansen, Robert Csaky
Williams Honors College, Honors Research Projects
The Adaptive Bike Pedals project is set out to create a new attachment for tricycle pedals that improves on a previous model. The need for these attachments is common in rehabilitation and physical therapy centers to help patients keep their feet on pedals when they are not able to. They can also be used in homes of families that have children with disabilities, diseases, or disorders that inhibit them from keeping their feet on the pedals. There are attachments on the market already, but the problem with those models is that they are costly and made for specific pedals. The …
Upper Extremity Mobility Device, Timothy J. Grassi, Jacob R. Miller
Upper Extremity Mobility Device, Timothy J. Grassi, Jacob R. Miller
Williams Honors College, Honors Research Projects
The goal of this project was to evaluate a clinical problem, explore possible solutions, and produce a functioning prototype that would conform to all the established guidelines and requirements. The project focused on developing an upper extremity mobility device for a singular client with limited muscle activity in his arms due to childhood polio. Our design process was governed by an adapted form of the FDA Design Control Process, 21 CFR 820.30 [1]. The outcome of this project was a functioning prototype that utilized the concept of a motorized pulley system remote controlled using a key fob. This research project …
Prosthetic Foot/Ankle Inversion & Eversion Enhancement, Jason Wiebrecht, Maddison Grimes
Prosthetic Foot/Ankle Inversion & Eversion Enhancement, Jason Wiebrecht, Maddison Grimes
Williams Honors College, Honors Research Projects
Modify a prosthetic foot/ankle, that currently has power at the ankle joint, for dorsiflexion/flexion so that it supplies power across a simulated subtalar joint, making the joint capable of inversion/eversion.
The Tera Multi Terrain Mobility Aid Chassis, Colton Kemp, Daniel Nicoll, Ibrahim Suleiman, Mohammad Alyami
The Tera Multi Terrain Mobility Aid Chassis, Colton Kemp, Daniel Nicoll, Ibrahim Suleiman, Mohammad Alyami
Williams Honors College, Honors Research Projects
The natural environment poses a significant number of obstacles and dynamic settings that makes mobility difficult for those with physical and mobility impairments. To approach this problem, a suspension was designed using inspiration from the early Mars rovers developed by NASA for traversing the varied Martian landscape. The course of the project followed the direction of a start-up through problem identification, early design generation and review, and final design production. The project outcome, through client request and proven market research, aimed to produce a multi-terrain wheelchair. The final product is a kinematic body with mobile front “legs” and a rotational …
Prosthetic Hand, Nicholas Damiani, Eric Rassavong, John Zolton
Prosthetic Hand, Nicholas Damiani, Eric Rassavong, John Zolton
Williams Honors College, Honors Research Projects
Development of a prosthetic hand for an above-the-wrist amputee. The hand will provide flexion and extension of the wrist, fingers and thumb. The device will be customized for each individual by utilizing an medical imaging of the amputation side stump and the normal arm/wrist as the input. An integral hand/wrist and socket will be 3D printed, and actuators will be mounted to the prosthetic to provide motion. The wrist will be a mirror-image of the normal hand. Materials utilized will be selected based on the medical image intensity for different tissue types (cartilage, bone, skin, fat, etc.) and will simulate …
Design, Construction And Application Of A Home-Built, Two-Photon Microscope, William P. Breeding
Design, Construction And Application Of A Home-Built, Two-Photon Microscope, William P. Breeding
Electronic Theses and Dissertations
Two-photon microscopy (TPM) is a powerful, versatile imaging modality for the study of biological systems. This thesis overviews the relevant physics involved in TPM, design considerations and process of constructing a home-built, two-photon microscope, and provides a set of procedures to operate the system. Furthermore, this work explores several applications of TPM through the study of single-cell metabolism and imaging the cellular-material interface. Explored in particular depth was the imaging of cellulose nanofiber (CNF) materials, with the goal of understanding the three-dimensional nature of fibroblast cell growth when embedded within the materials. This work uncovered several optical properties of CNF, …
The Effect Of Implant Conformity On Muscle Force Requirements In The Implanted Knee, Grace Mcconnochie
The Effect Of Implant Conformity On Muscle Force Requirements In The Implanted Knee, Grace Mcconnochie
Boise State University Theses and Dissertations
Implant geometry is a significant factor in determining knee stability and patient satisfaction following total knee replacement (TKR). Ineffective muscle recruitment, impaired joint functionality and increased implant wear are consequences of an unstable knee replacement. Current knee laxity evaluation techniques are limited in their ability to account for the muscular response to knee instability. This study utilizes a subject specific lower-body musculoskeletal finite element (FE) model with dynamic muscle loading to evaluate implant laxity during activities of daily living. The effect of varying implant conformity on the muscle forces required to maintain a target kinematic profile during simulated laxity testing …
On-Demand Label Production, Robert A. Zimmerman
On-Demand Label Production, Robert A. Zimmerman
Master's Theses
The production and approval process for the various labels used in clinical trials wastes significant time and resources through the need to outsource label production or rely on large reams of pre-cut label stock for each revision throughout the process. An in-house, on-demand label printing and cutting system is a potential remedy to this waste. Previous work by Cheadle et al. resulted in a functional electomechanical prototype of the label cutting aspect of this research, capable of rudimentary linear cuts. In this continued research, emphasis was placed on improved label cutting capabilities and creating PC control software for label design. …
Hands-Free Ultrasound Transducer Attachment, Christina Harrison, Glenn Farina, Harshveer Dhaliwal
Hands-Free Ultrasound Transducer Attachment, Christina Harrison, Glenn Farina, Harshveer Dhaliwal
Biomedical Engineering
This document describes a background on current ultrasound technologies and the troubles that have inspired the need for a hands-free ultrasound transducer device, as well as the regulatory requirements, like patents and standard codes, for the intended invention. It also explains the Stage Gate Review process used to project plan the design of the device, a description of the final design and how it was developed, and the IQ/OQ/PQ. The objectives necessary to design this device, in order to meet all the requirements of the sponsor, are also summarized here. The design process including manufacturing instructions, prototype evolution, and the …
Flash-Mold Machine For Manufacturing Drug Implants, Conor Vache, Sonja Daebelliehn, Ryan Thomson
Flash-Mold Machine For Manufacturing Drug Implants, Conor Vache, Sonja Daebelliehn, Ryan Thomson
Biomedical Engineering
This Final Project Report provides the reader with a comprehensive detailing of all of the actions and work that has been completed for this Senior Design Project. In this report, the Cal Poly Biomedical Engineering Senior Project Team will discuss some background on the existing Mark I Flash-Mold Machine currently in use by Gesea Biosciences, background information on Gesea Biosciences, the Customer Requirements and Design Specifications of the new machine, Quality Engineering considerations, design concepts discussed, design concepts chosen, safety considerations, prototype development, manufacturing, testing protocols, and testing results, etc.
Development And Exploration Of A Z-Shaped Foot And Ankle Internal Fixation Plate, Rhaz Shaghaghi Paul, Ian Hames, Sean Rich
Development And Exploration Of A Z-Shaped Foot And Ankle Internal Fixation Plate, Rhaz Shaghaghi Paul, Ian Hames, Sean Rich
Williams Honors College, Honors Research Projects
This paper will detail the design process of developing a Z-shaped foot and ankle internal fixation plating system. Group 6: Plates for the Sole was made up of 5 team members, who worked together to accommodate their client’s request to complete a biomechanical analysis of a Z-Plate design and a construct a prototype. The Z-Plate’s purpose is to provide podiatrists with a new solution that can fit nicely on the small, irregular bones of the foot, while also remaining strong enough to withstand the forces and torques of the foot.
Project "Auxilia" - Jaiden's Prosthetic Arm, Christopher Halley, Lindsay Jaros, Autumn Young
Project "Auxilia" - Jaiden's Prosthetic Arm, Christopher Halley, Lindsay Jaros, Autumn Young
Williams Honors College, Honors Research Projects
The main objective of this project was to create a prosthetic arm for a 15 year old boy named Jaiden Foden. Jaiden was born with only one fully developed limb as a result of a genetic disorder, Hanhart Syndrome II. His right arm becomes a residual limb below the elbow, but has two fingers which act in a “claw-like” movement. Jaiden’s left arm becomes a residual limb above the elbow, and his left leg becomes a residual limb above the knee. The goal of the arm was to increase Jaiden’s overall independence and to help in completing daily tasks, such …
Easy Adjustable Protective Helmet, Ryan Balash
Easy Adjustable Protective Helmet, Ryan Balash
Williams Honors College, Honors Research Projects
Akron Children’s Hospital and The University of Akron’s Biomedical Engineering Design Team Engineering Forward have paired together to improve medical adapted helmets for post-operative and disabled patients. An issue is the helmets are only produced in a couple of sizes. Also, it is a tedious process to constantly adjust the pressure on the patient’s cranium within a trial-and-error process. Engineering Forward plans to improve the effectiveness of this helmet by creating an adjustable helmet that can read the pressure on a patient’s head. The caregiver can then make the necessary adjustments to the helmet to accommodate the patient. Documents of …
The Wrist Brace Project, Nathan Nicholas
The Wrist Brace Project, Nathan Nicholas
Williams Honors College, Honors Research Projects
This paper outlines the engineering design process of creating a specialized wrist brace for a local child. This project was completed by a team of senior Biomedical Engineering students.
Developing Strategies To Toughen Bio-Inspired Adhesives, Narelli P. Narciso, Samuel Lee Huntington, Jonathan J. Wilker
Developing Strategies To Toughen Bio-Inspired Adhesives, Narelli P. Narciso, Samuel Lee Huntington, Jonathan J. Wilker
The Summer Undergraduate Research Fellowship (SURF) Symposium
Mussels and other marine creatures adhere very well in underwater environments, having the ability to withstand the force of the sea. These animals have inspired synthetic biomimetic adhesives for wet systems, presenting potential for biomedical applications. However, most current commercial adhesives tend to be brittle, not resisting repetitive movements. This study assesses toughening strategies to improve the mussel-inspired adhesives’ ductility while maintaining its strength. The strategies included altering the polymer’s chemical structure by changing the percentage of polyethylene glycol (PEG) in the molecule and by adding fillers, such as calcium carbonate, silica and nacre - a calcium carbonate compound found …