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Articles 1 - 4 of 4
Full-Text Articles in Biomedical Engineering and Bioengineering
A Feasibility Study Of Just-In-Time Asthma Self-Management Intervention, Phillip Charles Scruggs
A Feasibility Study Of Just-In-Time Asthma Self-Management Intervention, Phillip Charles Scruggs
Masters Theses
Quality asthma care requires not only an initial diagnosis, but long term follow up care and education on long term control. Preventable symptoms continue to reduce the quality of life for chronic asthma sufferers and place an unnecessary burden on emergency services and the health care system at large. A mobile health (mHealth) solution is proposed to effectively improve outcomes for patients while ultimately reducing the overall burden of mismanagement on the healthcare system as a whole. The Just-in-Time Asthma Self- Management and Intervention (JASMIN) system provides a way for a patient or user to track, self-manage, and interact with …
Modeling The Spatiotemporal Dynamics Of Cells In The Lung, Joshua Jeremy Pothen
Modeling The Spatiotemporal Dynamics Of Cells In The Lung, Joshua Jeremy Pothen
Graduate College Dissertations and Theses
Multiple research problems related to the lung involve a need to take into account the spatiotemporal dynamics of the underlying component cells. Two such problems involve better understanding the nature of the allergic inflammatory response to explore what might cause chronic inflammatory diseases such as asthma, and determining the rules underlying stem cells used to engraft decellularized lung scaffolds in the hopes of growing new lungs for transplantation. For both problems, we model the systems computationally using agent-based modeling, a tool that enables us to capture these spatiotemporal dynamics by modeling any biological system as a collection of agents (cells) …
A Protocol For A Randomised Clinical Trial Of The Effect Of Providing Feedback On Inhaler Technique And Adherence From An Electronic Device In Patients With Poorly Controlled Severe Asthma, Imran Sulaiman, Martin Holmes, Shona D'Arcy, Viliam Rapčan, Desmond Michael Murphy, Gloria Crispino, Isabelle Killane, Rw Costello, Richard B Reilly, Jansen Seheult, Gregory Diette, Elaine Machale, Terence Taylor
A Protocol For A Randomised Clinical Trial Of The Effect Of Providing Feedback On Inhaler Technique And Adherence From An Electronic Device In Patients With Poorly Controlled Severe Asthma, Imran Sulaiman, Martin Holmes, Shona D'Arcy, Viliam Rapčan, Desmond Michael Murphy, Gloria Crispino, Isabelle Killane, Rw Costello, Richard B Reilly, Jansen Seheult, Gregory Diette, Elaine Machale, Terence Taylor
Articles
ntroduction In clinical practice, it is difficult to distinguish between patients with refractory asthma from those with poorly controlled asthma, where symptoms persist due to poor adherence, inadequate inhaler technique or comorbid diseases. We designed an audio recording device which, when attached to an inhaler, objectively identifies the time and technique of inhaler use, thereby assessing both aspects of adherence. This study will test the hypothesis that feedback on these two aspects of adherence when passed on to patients improves adherence and helps clinicians distinguish refractory from difficult-to-control asthma. Methods This is a single, blind, prospective, randomised, clinical trial performed …
Development And Characterization Of A 3d Multicell Microtissue Culture Model Of Airway Smooth Muscle., Glenn Gaudette, Adrian West, Nishat Zaman, Darren Cole, Matthew Walker, Wesley Legant, Thomas Boudou, Christopher Chen, John Favreau, Elizabeth Cowley, Geoffrey Maksym
Development And Characterization Of A 3d Multicell Microtissue Culture Model Of Airway Smooth Muscle., Glenn Gaudette, Adrian West, Nishat Zaman, Darren Cole, Matthew Walker, Wesley Legant, Thomas Boudou, Christopher Chen, John Favreau, Elizabeth Cowley, Geoffrey Maksym
Glenn R. Gaudette
Airway smooth muscle (ASM) cellular and molecular biology is typically studied with single-cell cultures grown on flat 2D substrates. However, cells in vivo exist as part of complex 3D structures, and it is well established in other cell types that altering substrate geometry exerts potent effects on phenotype and function. These factors may be especially relevant to asthma, a disease characterized by structural remodeling of the airway wall, and highlights a need for more physiologically relevant models of ASM function. We utilized a tissue engineering platform known as microfabricated tissue gauges to develop a 3D culture model of ASM featuring …