Biomedical Engineering and Bioengineering Commons^™

Effects Of Short Term Hypoxia-Preconditioning On Glial Phenotype Induction Of Human Mesenchymal Stem Cells, Zichen Qian, Qi Xing, Corey Fase, Kyle Jansen, Feng Zhao

Michigan Tech Publications

Development of successful clinical treatments for peripheral nerve injury is limited due to the complications behind neural physiology. Human mesenchymal stem cells (hMSCs) have the ability to directly promote tissue repair and protect cells at the injury site. Studies have shown that hMSCs can be transplanted to improve nerve regeneration. Hypoxic culture condition has been proven to maintain the stemness of hMSCs for later differentiation. In this study, we investigated the effects of low oxygen (O₂) (2% and 5% O₂) pre-treatment and initial seeding density (500, 1000, and 2000 cells/cm²) on glial protein expression …

Development Of Peritoneal Microbubble Oxygenation As An Extrapulmonary Treatment For Hypoxia, Nathan Legband

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Patients affected by a respiratory disease or injury experience a substantially impaired respiratory system and as a consequence are unable to obtain a sufficient amount of oxygen. Hypoxia can quickly result in developing permanent tissue damage or death. Currently, the medical methods of treating hypoxia are mechanical ventilation or extracorporeal membrane oxygenation. However, these treatments are ineffective in certain cases and possess significant additional risks including barotrauma, infection, hemorrhage, and thrombosis.

The extrapulmonary method of peritoneal oxygenation has been investigated by other research groups as a potential alternative to providing supplemental oxygen in hypoxic animals. In peritoneal oxygenation, the peritoneum, …

Oxygen Transport In Carotid And Stented Coronary Arteries, Eoin A. Murphy

Doctoral

Oxygen deficiency, known as hypoxia, in arterial walls has been linked to increased intimal hyperplasia, which is the main adverse biological process causing in-stent restenosis. Stent implantation can have significant effects on the oxygen transport into the arterial wall. Helical flow has been theorised to improve the local haemodynamics and the oxygen transport within stented arteries. In this study an advanced oxygen transport model was developed to assess different stent designs. This advanced oxygen transport model incorporates both the free and bound oxygen contained in blood and includes a shear-dependent dispersion coefficient for red blood cells. In two test cases …